DE69113455D1 - Cyclische hydroxamsaeuren und ihre verwendung. - Google Patents

Cyclische hydroxamsaeuren und ihre verwendung.

Info

Publication number
DE69113455D1
DE69113455D1 DE69113455T DE69113455T DE69113455D1 DE 69113455 D1 DE69113455 D1 DE 69113455D1 DE 69113455 T DE69113455 T DE 69113455T DE 69113455 T DE69113455 T DE 69113455T DE 69113455 D1 DE69113455 D1 DE 69113455D1
Authority
DE
Germany
Prior art keywords
pct
hydrogen
halogen
lower alkyl
date oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69113455T
Other languages
English (en)
Other versions
DE69113455T2 (de
Inventor
Reijo Baeckstroem
Erkki Honkanen
Atso Raasmaja
Inge-Britt Linden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Publication of DE69113455D1 publication Critical patent/DE69113455D1/de
Application granted granted Critical
Publication of DE69113455T2 publication Critical patent/DE69113455T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Earth Drilling (AREA)
DE69113455T 1990-04-26 1991-04-26 Cyclische hydroxamsaeuren und ihre verwendung. Expired - Fee Related DE69113455T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909009395A GB9009395D0 (en) 1990-04-26 1990-04-26 Cyclic hydroxamic acids and their use
PCT/FI1991/000123 WO1991016303A1 (en) 1990-04-26 1991-04-26 Cyclic hydroxamic acids and their use

Publications (2)

Publication Number Publication Date
DE69113455D1 true DE69113455D1 (de) 1995-11-02
DE69113455T2 DE69113455T2 (de) 1996-03-21

Family

ID=10675035

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113455T Expired - Fee Related DE69113455T2 (de) 1990-04-26 1991-04-26 Cyclische hydroxamsaeuren und ihre verwendung.

Country Status (13)

Country Link
US (1) US5356923A (de)
EP (1) EP0526535B1 (de)
JP (1) JP3227155B2 (de)
AT (1) ATE128462T1 (de)
AU (1) AU7777491A (de)
DE (1) DE69113455T2 (de)
DK (1) DK0526535T3 (de)
ES (1) ES2078519T3 (de)
FI (1) FI100052B (de)
GB (1) GB9009395D0 (de)
GR (1) GR3017821T3 (de)
WO (1) WO1991016303A1 (de)
ZA (1) ZA912886B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234933A (en) * 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
DE69309030T2 (de) * 1992-06-15 1997-09-25 Celltech Therapeutics Ltd Trisubstituierte phenylderivate als selektive phosphodiesterase iv inhibitoren
EP0711282B1 (de) 1993-07-28 2002-06-05 Aventis Pharma Limited Verbindungen als pde iv und tnf inhibitoren
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
US5502072A (en) * 1993-11-26 1996-03-26 Pfizer Inc. Substituted oxindoles
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
IL161317A0 (en) 2001-10-16 2004-09-27 Memory Pharm Corp 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
BRPI0410235A (pt) 2003-04-16 2006-05-09 Memory Pharm Corp inibição de pde4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento
AU2005295350A1 (en) 2004-10-20 2006-04-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
CN102491929B (zh) * 2011-12-08 2014-04-30 贵州省中国科学院天然产物化学重点实验室 1-羟基-2-吡咯烷酮类化合物及其制备方法和应用
CN110407681B (zh) * 2019-08-12 2023-05-02 海南大学 一种脱氢姜酮衍生物、其制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
LU85404A1 (fr) * 1984-06-06 1986-01-24 Continental Pharma Derives d'acides hydroxamiques cycliques,leur preparation et utilisation ainsi que les compositions contenant ces derives
IE59397B1 (en) * 1985-03-16 1994-02-23 Wellcome Found New aryl derivatives
EP0196184B1 (de) * 1985-03-16 1992-09-16 The Wellcome Foundation Limited Aryl-Derivate
GB8531839D0 (en) * 1985-12-30 1986-02-05 Wellcome Found Aryl derivatives

Also Published As

Publication number Publication date
ES2078519T3 (es) 1995-12-16
AU7777491A (en) 1991-11-11
DE69113455T2 (de) 1996-03-21
FI924839A0 (fi) 1992-10-23
FI100052B (fi) 1997-09-15
JPH05506236A (ja) 1993-09-16
ZA912886B (en) 1992-01-29
EP0526535B1 (de) 1995-09-27
JP3227155B2 (ja) 2001-11-12
GB9009395D0 (en) 1990-06-20
WO1991016303A1 (en) 1991-10-31
US5356923A (en) 1994-10-18
EP0526535A1 (de) 1993-02-10
GR3017821T3 (en) 1996-01-31
DK0526535T3 (da) 1995-11-27
ATE128462T1 (de) 1995-10-15
FI924839A (fi) 1992-10-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee