DE69113025D1 - Drei neue nichtpolyglutamisierende deazaaminopterine und verfahren zur herstellung. - Google Patents

Drei neue nichtpolyglutamisierende deazaaminopterine und verfahren zur herstellung.

Info

Publication number
DE69113025D1
DE69113025D1 DE69113025T DE69113025T DE69113025D1 DE 69113025 D1 DE69113025 D1 DE 69113025D1 DE 69113025 T DE69113025 T DE 69113025T DE 69113025 T DE69113025 T DE 69113025T DE 69113025 D1 DE69113025 D1 DE 69113025D1
Authority
DE
Germany
Prior art keywords
polyglutamizing
deazaaminopterins
production
new non
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69113025T
Other languages
English (en)
Other versions
DE69113025T2 (de
Inventor
Madhavan Nair
Ann E- Abraham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAIR MADHAVAN G MOBILE ALA US
Original Assignee
NAIR MADHAVAN G MOBILE ALA US
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAIR MADHAVAN G MOBILE ALA US filed Critical NAIR MADHAVAN G MOBILE ALA US
Publication of DE69113025D1 publication Critical patent/DE69113025D1/de
Application granted granted Critical
Publication of DE69113025T2 publication Critical patent/DE69113025T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69113025T 1990-01-18 1991-01-11 Drei neue nichtpolyglutamisierende deazaaminopterine und verfahren zur herstellung. Expired - Fee Related DE69113025T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/467,025 US4996207A (en) 1990-01-18 1990-01-18 Three new non-polyglutamatable deazaaminopterins
PCT/US1991/000220 WO1991010666A1 (en) 1990-01-18 1991-01-11 Three new non-polyglutamatable deazaaminopterins and process for preparing the same

Publications (2)

Publication Number Publication Date
DE69113025D1 true DE69113025D1 (de) 1995-10-19
DE69113025T2 DE69113025T2 (de) 1996-04-04

Family

ID=23854033

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113025T Expired - Fee Related DE69113025T2 (de) 1990-01-18 1991-01-11 Drei neue nichtpolyglutamisierende deazaaminopterine und verfahren zur herstellung.

Country Status (5)

Country Link
US (1) US4996207A (de)
EP (1) EP0513068B1 (de)
JP (1) JP2958902B2 (de)
DE (1) DE69113025T2 (de)
WO (1) WO1991010666A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996207A (en) * 1990-01-18 1991-02-26 Nair Madhavan G Three new non-polyglutamatable deazaaminopterins
US5073554A (en) * 1990-01-18 1991-12-17 Nair Madhavan G Two non-polyglutamatable antifolates
US5030634A (en) * 1990-03-29 1991-07-09 Krumdieck Carlos L 10-deazaaminopterin: a new arthritis remittive drug
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
US5260296A (en) * 1992-05-13 1993-11-09 Nair Madhavan G Thiophene substituted antitumor antifolates
US5550128A (en) * 1994-09-09 1996-08-27 Nair; Madhavan G. Enantiomers of gamma methylene 10-deaza aminopterin and process for preparing the same
AU7624498A (en) * 1996-12-02 1998-06-29 Bionumerik Pharmaceuticals, Inc. Process for making gamma-methylene-10-deazaaminopterin (MDAM)
US5922714A (en) * 1996-12-26 1999-07-13 Bionumerik Pharmaceuticals, Inc. Combination of MDAM and 5-fluoropyrimidines for treating cancer
US5912251A (en) * 1998-01-17 1999-06-15 Nair; Madhavan G. Metabolically inert anti-inflammatory and anti-tumor antifolates
IL146566A0 (en) * 1999-05-24 2002-07-25 Sankyo Co A pharmaceutical composition containing anti-fas antibody
ES2261722T3 (es) * 2001-04-04 2006-11-16 Bionumerik Pharmaceuticals, Inc. Procedimiento para el acoplamiento de aminoacidos a un andamiaje de antifolato.
US6977311B2 (en) * 2002-10-25 2005-12-20 Bionumerik Pharmaceuticals, Inc. Process for synthesizing L-γ-methylene glutamic acid and analogs
WO2006029385A2 (en) * 2004-09-08 2006-03-16 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds.
JP2010516694A (ja) * 2007-01-19 2010-05-20 チェルシー・セラピューティクス，インコーポレイテッド 新規な伝統的葉酸拮抗剤
AU2009233829A1 (en) * 2008-04-07 2009-10-15 Chelsea Therapeutics, Inc. Crystalline salt forms of antifolate compounds and methods of manufacturing thereof
MX2012000437A (es) 2009-07-08 2012-02-21 Chelsea Therapeutics Inc Polimorfos cristalinos estables de la sal dipotasica de acido (s)-2-{2,4-diamono-quizolin-6-il)-etil]-benzoilamino}-4-metilen-p entanodioico.
EP2496237A2 (de) * 2009-11-06 2012-09-12 Chelsea Therapeutics, Inc. Enzymhemmende verbindungen
US20110237609A1 (en) * 2010-03-29 2011-09-29 Chelsea Therapeutics, Inc. Antifolate compositions
RU2556209C2 (ru) * 2010-12-03 2015-07-10 Кочак Фарма Илач Ве Кимя Сан. А.С Новый способ получения антифолатных агентов, имеющих в своей структуре фрагмент глутаминовой кислоты
WO2012078708A1 (en) 2010-12-07 2012-06-14 Chelsea Therapeutics, Inc. Combination comprising methotrexate and an antifolate compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393064A (en) * 1976-03-05 1983-07-12 Sri International Process and composition for treatment of leukemia and process for preparing the same
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4628090A (en) * 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
JPS6281385A (ja) * 1985-10-02 1987-04-14 Shionogi & Co Ltd 新規メトトレキサ−ト誘導体
US4889859A (en) * 1988-02-05 1989-12-26 The Trustees Of Princeton University Pyrido[2,3-d]pyrimidine derivatives
US4996207A (en) * 1990-01-18 1991-02-26 Nair Madhavan G Three new non-polyglutamatable deazaaminopterins

Also Published As

Publication number Publication date
JP2958902B2 (ja) 1999-10-06
JPH04505932A (ja) 1992-10-15
EP0513068B1 (de) 1995-09-13
DE69113025T2 (de) 1996-04-04
EP0513068A1 (de) 1992-11-19
WO1991010666A1 (en) 1991-07-25
EP0513068A4 (en) 1993-06-30
US4996207A (en) 1991-02-26

Similar Documents

Publication Publication Date Title
DE69015489D1 (de) Dekorationsfilm und verfahren zur herstellung.
DE69113025D1 (de) Drei neue nichtpolyglutamisierende deazaaminopterine und verfahren zur herstellung.
DE69110475T2 (de) Verfahren zur herstellung von perfluorolefinen.
DE69201589D1 (de) Wachsumhüllte Partikel und Verfahren zur Herstellung derselben.
DE59004945D1 (de) Tank und Verfahren zur Herstellung desselben.
ATE208628T1 (de) Neue antithrombotische formulierung, verfahren zur herstellung und gebrauch davon
DE69105275T2 (de) Verfahren zur herstellung von tertiären perfluoraminen.
DE69020586D1 (de) Verfahren zur herstellung von 1-okten.
DE59103921D1 (de) Verfahren zur herstellung von glycerinethersulfaten.
DE68917457T2 (de) Deodorant und verfahren zur herstellung.
DE59002322D1 (de) Verfahren zur herstellung von 1,1,1,3,3,3-hexafluorpropan und 2-chlor-1,1,1,3,3,3-hexafluorpropan.
DE69102275D1 (de) Alumina enthaltende säureadsorbentien und verfahren zur herstellung derselben.
DE69126605D1 (de) Verbundfilm und verfahren zur herstellung
DE69020135D1 (de) Konvergierender filter und verfahren zur herstellung.
DE69119413T2 (de) Resistmaterial und verfahren zur herstellung
DE59106553D1 (de) Verfahren zur herstellung von chlorfluornitrobenzolen und difluornitrobenzolen.
DE445493T1 (de) Verfahren zur herstellung von chlordioxyd.
ATA175790A (de) Dichtungselement und verfahren zur herstellung
DE3765855D1 (de) Dimethylphenylsilylmethylpolysilan und verfahren zur herstellung desselben.
DE3851541D1 (de) Propylen-äthylen-kopolymer-zusammensetzung und verfahren zur herstellung.
DE69107086D1 (de) Verfahren zur herstellung von glycosylphosphattriestern.
DE69111659T2 (de) Pigment und Verfahren zur Herstellung desselben.
DE3584026D1 (de) Collagenase und verfahren zur herstellung derselben.
DE68905578T2 (de) Verbindung ks-505 und verfahren zur herstellung davon.
DE59301017D1 (de) Verfahren zur herstellung von hexafluorbutan.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee