DE69101835D1 - N-phenyl-n-acetamidoglycinamide, ihre herstellung und medikamente, die sie enthalten. - Google Patents
N-phenyl-n-acetamidoglycinamide, ihre herstellung und medikamente, die sie enthalten.Info
- Publication number
- DE69101835D1 DE69101835D1 DE69101835T DE69101835T DE69101835D1 DE 69101835 D1 DE69101835 D1 DE 69101835D1 DE 69101835 T DE69101835 T DE 69101835T DE 69101835 T DE69101835 T DE 69101835T DE 69101835 D1 DE69101835 D1 DE 69101835D1
- Authority
- DE
- Germany
- Prior art keywords
- unsubstituted
- radical
- pct
- substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
- C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9001553A FR2658196B1 (fr) | 1990-02-09 | 1990-02-09 | N-phenyl n-acetamido glycinamides leur preparation et les medicaments les contenant. |
FR9011916A FR2667319B2 (fr) | 1990-02-09 | 1990-09-27 | N-phenyl n-acetamido glycinamides, leur preparation et les medicaments les contenant. |
FR9012594A FR2667863B2 (fr) | 1990-02-09 | 1990-10-12 | N-phenyl n-acetamido glycinamides, leur preparation et les medicaments les contenant. |
PCT/FR1991/000087 WO1991012264A1 (fr) | 1990-02-09 | 1991-02-06 | N-phenyl n-acetamido glycinamides, leur preparation et les medicaments les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69101835D1 true DE69101835D1 (de) | 1994-06-01 |
DE69101835T2 DE69101835T2 (de) | 1994-08-18 |
Family
ID=27252134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69101835T Expired - Fee Related DE69101835T2 (de) | 1990-02-09 | 1991-02-06 | N-phenyl-n-acetamidoglycinamide, ihre herstellung und medikamente, die sie enthalten. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5382590A (de) |
EP (1) | EP0514442B1 (de) |
JP (1) | JPH05506643A (de) |
KR (1) | KR927003625A (de) |
AT (1) | ATE104989T1 (de) |
AU (1) | AU639081B2 (de) |
CA (1) | CA2072981A1 (de) |
DE (1) | DE69101835T2 (de) |
DK (1) | DK0514442T3 (de) |
ES (1) | ES2052372T3 (de) |
HU (1) | HUT61575A (de) |
IE (1) | IE910428A1 (de) |
IL (1) | IL97180A0 (de) |
NO (1) | NO923079L (de) |
NZ (1) | NZ237052A (de) |
PT (1) | PT96712A (de) |
WO (1) | WO1991012264A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658518B1 (fr) * | 1990-02-19 | 1992-04-30 | Rhone Poulenc Sante | N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant. |
GB9206757D0 (en) * | 1992-03-27 | 1992-05-13 | Ferring Bv | Novel peptide receptor ligands |
FR2695643B1 (fr) * | 1992-09-11 | 1994-11-25 | Rhone Poulenc Rorer Sa | Dérivés d'uréido-acétamide, leur préparation et les médicaments les contenant. |
FR2695641B1 (fr) * | 1992-09-11 | 1994-11-25 | Rhone Poulenc Rorer Sa | (Amino-3 phényl)-1 éthanesulfonate d'hydroquinine optiquement actif, sa préparation et son utilisation. |
PT739903E (pt) * | 1994-02-09 | 2002-05-31 | Shionogi & Co | Derivado carbamoilmetilureia |
GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
AU4891396A (en) * | 1995-03-14 | 1996-10-02 | Daiichi Pharmaceutical Co., Ltd. | Aminophenol derivatives |
US6297269B1 (en) | 1995-06-06 | 2001-10-02 | Pfizer Inc. | Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors |
KR100241643B1 (ko) | 1995-06-06 | 2000-03-02 | 디. 제이. 우드 | 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체 |
US6107329A (en) * | 1995-06-06 | 2000-08-22 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors |
DE69615570T2 (de) * | 1995-08-07 | 2002-07-11 | Shionogi & Co | Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten |
FR2744364B1 (fr) * | 1996-02-07 | 1998-02-27 | Rhone Poulenc Rorer Sa | Application d'ureidoacetamides a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
MX2010013192A (es) * | 2008-06-16 | 2010-12-17 | Hoffmann La Roche | Monoamidas heteroaromaticas como antagonistas de receptor orexinina. |
WO2011044327A1 (en) | 2009-10-07 | 2011-04-14 | Medivation Prostate Therapeutics, Inc. | Substituted phenylcarbamoyl alkylamino arene compounds and n,n'-bis-arylurea compounds |
CN107789354B (zh) * | 2016-08-31 | 2022-02-25 | 中国科学院上海药物研究所 | 预防和治疗抑郁症的化合物及其应用 |
CN109020887B (zh) * | 2017-06-10 | 2022-03-01 | 绍兴从零医药科技有限公司 | 作为防治精神障碍疾病的酰胺类化合物 |
CN108689877B (zh) * | 2018-07-06 | 2021-08-03 | 浙江工业大学 | 一种含手性碳的双酰胺类化合物及其制备方法与应用 |
US11596612B1 (en) | 2022-03-08 | 2023-03-07 | PTC Innovations, LLC | Topical anesthetics |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2533210A1 (fr) * | 1982-09-17 | 1984-03-23 | Lyon I Universite Claude | Edulcorants de synthese |
EP0166355A2 (de) * | 1984-06-26 | 1986-01-02 | Merck & Co. Inc. | Substituierte Aminophenyl- und Acylaminophenyl-Verbindungen und deren pharmazeutische Zusammensetzungen |
EP0175498A2 (de) * | 1984-08-23 | 1986-03-26 | The Administrators Of The Tulane University Educational Fund | Peptide, deren Verwendung in der Heilkunde und Verfahren zu deren Herstellung |
FR2646847B1 (fr) * | 1989-05-12 | 1991-07-12 | Rhone Poulenc Sante | N-phenyl amides, leurs procedes de preparation et les medicaments les contenant |
-
1991
- 1991-02-06 WO PCT/FR1991/000087 patent/WO1991012264A1/fr active IP Right Grant
- 1991-02-06 US US07/867,690 patent/US5382590A/en not_active Expired - Fee Related
- 1991-02-06 HU HU922585A patent/HUT61575A/hu unknown
- 1991-02-06 AU AU73295/91A patent/AU639081B2/en not_active Ceased
- 1991-02-06 CA CA002072981A patent/CA2072981A1/fr not_active Abandoned
- 1991-02-06 KR KR1019920701912A patent/KR927003625A/ko not_active Application Discontinuation
- 1991-02-06 ES ES91903956T patent/ES2052372T3/es not_active Expired - Lifetime
- 1991-02-06 DK DK91903956.0T patent/DK0514442T3/da active
- 1991-02-06 JP JP91504069A patent/JPH05506643A/ja active Pending
- 1991-02-06 DE DE69101835T patent/DE69101835T2/de not_active Expired - Fee Related
- 1991-02-06 EP EP91903956A patent/EP0514442B1/de not_active Expired - Lifetime
- 1991-02-06 AT AT9191903956T patent/ATE104989T1/de active
- 1991-02-07 IL IL97180A patent/IL97180A0/xx unknown
- 1991-02-08 PT PT96712A patent/PT96712A/pt not_active Application Discontinuation
- 1991-02-08 IE IE042891A patent/IE910428A1/en unknown
- 1991-02-08 NZ NZ237052A patent/NZ237052A/xx unknown
-
1992
- 1992-08-05 NO NO92923079A patent/NO923079L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HUT61575A (en) | 1993-01-28 |
ATE104989T1 (de) | 1994-05-15 |
PT96712A (pt) | 1991-10-31 |
JPH05506643A (ja) | 1993-09-30 |
NZ237052A (en) | 1992-12-23 |
CA2072981A1 (fr) | 1991-08-10 |
US5382590A (en) | 1995-01-17 |
ES2052372T3 (es) | 1994-07-01 |
WO1991012264A1 (fr) | 1991-08-22 |
IL97180A0 (en) | 1992-05-25 |
IE910428A1 (en) | 1991-08-14 |
EP0514442A1 (de) | 1992-11-25 |
DK0514442T3 (da) | 1994-09-26 |
KR927003625A (ko) | 1992-12-18 |
NO923079D0 (no) | 1992-08-05 |
NO923079L (no) | 1992-08-05 |
AU639081B2 (en) | 1993-07-15 |
AU7329591A (en) | 1991-09-03 |
DE69101835T2 (de) | 1994-08-18 |
EP0514442B1 (de) | 1994-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |