DE69033116D1 - Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene - Google Patents

Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene

Info

Publication number
DE69033116D1
DE69033116D1 DE69033116T DE69033116T DE69033116D1 DE 69033116 D1 DE69033116 D1 DE 69033116D1 DE 69033116 T DE69033116 T DE 69033116T DE 69033116 T DE69033116 T DE 69033116T DE 69033116 D1 DE69033116 D1 DE 69033116D1
Authority
DE
Germany
Prior art keywords
isopsoralene
inhibiting
nucleic acids
enzymatic production
radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69033116T
Other languages
English (en)
Inventor
Stephen T Isaacs
George D Cimino
Kenneth C Metchette
John W Tessman
John E Hearst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/428,494 external-priority patent/US5221608A/en
Priority claimed from US07/427,303 external-priority patent/US5139940A/en
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69033116D1 publication Critical patent/DE69033116D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Clinical Laboratory Science (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electron Beam Exposure (AREA)
  • Measurement Of Radiation (AREA)
DE69033116T 1989-10-26 1990-10-26 Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene Expired - Lifetime DE69033116D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/428,494 US5221608A (en) 1989-10-26 1989-10-26 Methods for rendering amplified nucleic acid subsequently unamplifiable
US07/427,303 US5139940A (en) 1989-10-26 1989-10-26 Activation compounds and methods of synthesis of activation compounds
PCT/US1990/006228 WO1991006665A1 (en) 1989-10-26 1990-10-26 Activation compounds and methods for nucleic acid sterilization

Publications (1)

Publication Number Publication Date
DE69033116D1 true DE69033116D1 (de) 1999-06-24

Family

ID=27027364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69033116T Expired - Lifetime DE69033116D1 (de) 1989-10-26 1990-10-26 Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene

Country Status (7)

Country Link
EP (2) EP0497921B1 (de)
JP (1) JPH05501713A (de)
AT (1) ATE180281T1 (de)
AU (1) AU649992B2 (de)
CA (1) CA2066234C (de)
DE (1) DE69033116D1 (de)
WO (1) WO1991006665A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5650302A (en) * 1990-05-01 1997-07-22 Amgen Inc. Method for reducing carryover contamination in an amplification procedure
HU218095B (hu) * 1990-05-01 2000-05-28 Amgen Inc. Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban
AU8920191A (en) * 1990-10-31 1992-05-26 George D. Cimino Methods and compositions for minimizing inhibition of nucleic acid amplification
BRPI0720342A2 (pt) 2006-10-04 2018-09-18 Janssen Pharmaceutica N.V. preparado de células apresentadoras de antígenos artificiais e seu uso em terapias celulares.
PL3662080T3 (pl) * 2017-08-02 2022-04-19 Sarstedt Ag & Co. Kg Sposób i formulacja do stabilizacji bezkomórkowych kwasów nukleinowych i komórek

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553236A (en) * 1968-12-06 1971-01-05 Franco Indian Pharmaceuticals Psoralene and isopsoralene, process for their isolation and separation
US4124598A (en) * 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
US4216154A (en) * 1979-03-15 1980-08-05 Thomas C. Elder, Inc. Process for making α-loweralkylfurocoumarins
IT1166343B (it) * 1979-08-20 1987-04-29 Francarosa Baccichetti Furocumarina per la fotochemioterapia della fsoriasi e di altre malattie cutanee ad essa sensibili
US4235781A (en) * 1979-09-20 1980-11-25 Thomas C. Elder, Inc. 6 Or 8 Haloallyl substituted 7-hydroxycoumarins
US4294822A (en) * 1980-07-29 1981-10-13 Thomas C. Elder, Inc. 5-Aminoalkyl-4,4,8-trialkylpsoralens
US4294847A (en) * 1980-07-29 1981-10-13 Thomas C. Elder, Inc. 8-Aminoalkyl-4-alkylisopsoralens
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
EP0124363B1 (de) * 1983-05-02 1990-12-19 Diamond Scientific Co. Photochemische Entkeimungsbehandlung von vollem Blut oder Blutbestandteilen
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
JPS61275228A (ja) * 1985-03-14 1986-12-05 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド 治療用タンパク組成物中のビ−ルスの光動的不活性化
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences

Also Published As

Publication number Publication date
ATE180281T1 (de) 1999-06-15
EP0497921A1 (de) 1992-08-12
EP0497921B1 (de) 1999-05-19
AU6959191A (en) 1991-05-31
CA2066234C (en) 2001-04-03
EP0890363A3 (de) 1999-08-25
WO1991006665A1 (en) 1991-05-16
JPH05501713A (ja) 1993-04-02
AU649992B2 (en) 1994-06-09
EP0890363A2 (de) 1999-01-13
CA2066234A1 (en) 1991-04-27
EP0497921A4 (de) 1995-06-28

Similar Documents

Publication Publication Date Title
DE69115276D1 (de) Vorrichtung und verfahren zur herstellung von optischen wellenleitern auf metallischen substraten.
DE3070460D1 (en) Compact fluorescent light source and method of excitation thereof
ATE89823T1 (de) Verfahren zur herstellung von baccatin-iiiderivaten und von desacetyl-10-baccatin-iii.
DE3880118D1 (de) Verwendung eines mittels in form von mikrokapseln zur schabenbekaempfung.
DE3777092D1 (de) Verfahren zur herstellung eines optischen aufzeichnungstraegers.
ATE28076T1 (de) Verfahren zur herstellung von tetrahydropyridinen.
DE3684519D1 (de) Verfahren zur herstellung eines optischen isolators.
DE69033116D1 (de) Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene
DE3883518D1 (de) Verfahren zur Herstellung von Silicium-Metall hoher Reinheit und Vorrichtung dafür.
DE3682985D1 (de) Verfahren zur herstellung eines optischen verzeichniselementes.
DE3674749D1 (de) Verfahren zur herstellung eines optischen glasartikels.
DE3783568D1 (de) Verfahren zur herstellung von koks hoher qualitaet.
DE3667960D1 (de) Verfahren zur herstellung von halogen-magnesium-alanat und dessen verwendung.
PT71563A (de) Verfahren zur elektrochemischen einstellung der pu (vi)-oxidationsstufe
ATA409179A (de) Verfahren und vorrichtung zur herstellung von optischen glasgegenstaenden
ATE95549T1 (de) Photolumineszente duennschicht-gegenstaende und methode zur herstellung derselben.
NO903338D0 (no) Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
ATE129238T1 (de) Verfahren zur herstellung von substituierten pyridylalkylketonen.
IT1224686B (it) Procedimento per la tintura o lastampa di pelli
DE3761139D1 (de) Verfahren zur herstellung von 4-formyltetrahydropyranen und neue 4-formyltetrahydropyrane.
DE69013770D1 (de) Entwicklungsverfahren zur Herstellung von Bildern von hoher Qualität.
IT1081628B (it) Processo per la idrogenazione di substrati aromatici e mezzi adatti allo scopo
DE3768594D1 (de) Verfahren zur herstellung von optischen wellenleitern in mittelinfrarotspektrum.
ATE61325T1 (de) Verfahren und vorrichtung zum kuehlen beim herstellen von floatglas.
ATA196391A (de) Verfahren zur gewinnung von platin hoher reinheit

Legal Events

Date Code Title Description
8332 No legal effect for de