ATE180281T1 - Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene - Google Patents

Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene

Info

Publication number
ATE180281T1
ATE180281T1 AT91901024T AT91901024T ATE180281T1 AT E180281 T1 ATE180281 T1 AT E180281T1 AT 91901024 T AT91901024 T AT 91901024T AT 91901024 T AT91901024 T AT 91901024T AT E180281 T1 ATE180281 T1 AT E180281T1
Authority
AT
Austria
Prior art keywords
isopsoralene
inhibiting
nucleic acids
enzymatic production
radiation
Prior art date
Application number
AT91901024T
Other languages
English (en)
Inventor
Stephen T Isaacs
George D Cimino
Kenneth C Metchette
John W Tessman
John E Hearst
Original Assignee
Stephen T Isaacs
George D Cimino
Kenneth C Metchette
John W Tessman
John E Hearst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/428,494 external-priority patent/US5221608A/en
Priority claimed from US07/427,303 external-priority patent/US5139940A/en
Application filed by Stephen T Isaacs, George D Cimino, Kenneth C Metchette, John W Tessman, John E Hearst filed Critical Stephen T Isaacs
Application granted granted Critical
Publication of ATE180281T1 publication Critical patent/ATE180281T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet [UV] radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT91901024T 1989-10-26 1990-10-26 Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene ATE180281T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/428,494 US5221608A (en) 1989-10-26 1989-10-26 Methods for rendering amplified nucleic acid subsequently unamplifiable
US07/427,303 US5139940A (en) 1989-10-26 1989-10-26 Activation compounds and methods of synthesis of activation compounds

Publications (1)

Publication Number Publication Date
ATE180281T1 true ATE180281T1 (de) 1999-06-15

Family

ID=27027364

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901024T ATE180281T1 (de) 1989-10-26 1990-10-26 Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene

Country Status (7)

Country Link
EP (2) EP0890363A3 (de)
JP (1) JPH05501713A (de)
AT (1) ATE180281T1 (de)
AU (1) AU649992B2 (de)
CA (1) CA2066234C (de)
DE (1) DE69033116D1 (de)
WO (1) WO1991006665A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
HU218095B (hu) * 1990-05-01 2000-05-28 Amgen Inc. Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban
US5650302A (en) * 1990-05-01 1997-07-22 Amgen Inc. Method for reducing carryover contamination in an amplification procedure
AU8920191A (en) * 1990-10-31 1992-05-26 George D. Cimino Methods and compositions for minimizing inhibition of nucleic acid amplification
EP2079830B1 (de) 2006-10-04 2016-08-17 Janssen Pharmaceutica NV Herstellung von zellen mit deaktivierten künstlichen antigenen und ihre verwendung in zelltherapien
ES2909392T3 (es) * 2017-08-02 2022-05-06 Sarstedt Ag & Co Kg Procedimiento y composición para la estabilización de ácidos nucleicos libres de células y células
CN116554190B (zh) * 2023-05-06 2025-12-05 河南中烟工业有限责任公司 一种香柑醇的合成方法及应用
CN116574108A (zh) * 2023-05-06 2023-08-11 河南中烟工业有限责任公司 一种补骨脂素的合成方法
CN116554189A (zh) * 2023-05-06 2023-08-08 河南中烟工业有限责任公司 一种异补骨脂素的高效制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553236A (en) * 1968-12-06 1971-01-05 Franco Indian Pharmaceuticals Psoralene and isopsoralene, process for their isolation and separation
US4124598A (en) * 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
US4216154A (en) * 1979-03-15 1980-08-05 Thomas C. Elder, Inc. Process for making α-loweralkylfurocoumarins
IT1166343B (it) * 1979-08-20 1987-04-29 Francarosa Baccichetti Furocumarina per la fotochemioterapia della fsoriasi e di altre malattie cutanee ad essa sensibili
US4235781A (en) * 1979-09-20 1980-11-25 Thomas C. Elder, Inc. 6 Or 8 Haloallyl substituted 7-hydroxycoumarins
US4294847A (en) * 1980-07-29 1981-10-13 Thomas C. Elder, Inc. 8-Aminoalkyl-4-alkylisopsoralens
US4294822A (en) * 1980-07-29 1981-10-13 Thomas C. Elder, Inc. 5-Aminoalkyl-4,4,8-trialkylpsoralens
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
DE3483751D1 (de) * 1983-05-02 1991-01-31 Diamond Scient Co Photochemische entkeimungsbehandlung von vollem blut oder blutbestandteilen.
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
JPS61275228A (ja) * 1985-03-14 1986-12-05 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド 治療用タンパク組成物中のビ−ルスの光動的不活性化
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences

Also Published As

Publication number Publication date
AU649992B2 (en) 1994-06-09
CA2066234A1 (en) 1991-04-27
EP0497921A1 (de) 1992-08-12
DE69033116D1 (de) 1999-06-24
EP0890363A3 (de) 1999-08-25
EP0890363A2 (de) 1999-01-13
WO1991006665A1 (en) 1991-05-16
EP0497921B1 (de) 1999-05-19
EP0497921A4 (de) 1995-06-28
AU6959191A (en) 1991-05-31
JPH05501713A (ja) 1993-04-02
CA2066234C (en) 2001-04-03

Similar Documents

Publication Publication Date Title
DE69019182D1 (de) Verfahren zur Herstellung von transparentem keramischem Material hoher Dichte.
DE69115276D1 (de) Vorrichtung und verfahren zur herstellung von optischen wellenleitern auf metallischen substraten.
DE3880118D1 (de) Verwendung eines mittels in form von mikrokapseln zur schabenbekaempfung.
DE3581197D1 (de) Verfahren und vorrichtung zur herstellung in bestimmten mengen von farbe und lack mittels volumdosierter farbmittel.
DE69027431D1 (de) Kumarinderivate zur verwendung als nukleotidvernetzungsreagenzien
DE69012535D1 (de) Verfahren zur Herstellung von Hydrogensiloxanen.
DE3887806D1 (de) Verfahren und Reaktionsgefäss zur Herstellung von Alkylnitrit.
ATE180281T1 (de) Verfahren zur hemmung der enzymatischen herstellung von nukleinsäuren mittels isopsoralene
BR8706589A (pt) Processo para tratamento de um meio aquoso e processo para tratamento de inibicao de um meio aquoso
DE58906804D1 (de) Verfahren zur optischen Prüfung von Flachbaugruppen.
ATA409179A (de) Verfahren und vorrichtung zur herstellung von optischen glasgegenstaenden
BR7906853A (pt) Processo de tratamento de um sinal analogico
ATE49185T1 (de) Verfahren zur herstellung von halogen-magnesium- alanat und dessen verwendung.
PT71563A (de) Verfahren zur elektrochemischen einstellung der pu (vi)-oxidationsstufe
ATE95549T1 (de) Photolumineszente duennschicht-gegenstaende und methode zur herstellung derselben.
NO903338D0 (no) Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
DE3585633D1 (de) Verfahren und vorrichtung zur herstellung von kalziniertem koks hoher qualitaet.
DE69011567D1 (de) Verfahren zur Herstellung von elektronischen und optischen Komponenten.
DE3578562D1 (de) Plasmareaktorgefaess und verfahren.
DE69029278D1 (de) Vorrichtung zur Herstellung von optischen Platten
DE69023978D1 (de) Verfahren zur Vernetzung von Methylwasserstoffpolysiloxanen.
IT1224686B (it) Procedimento per la tintura o lastampa di pelli
DE3761139D1 (de) Verfahren zur herstellung von 4-formyltetrahydropyranen und neue 4-formyltetrahydropyrane.
ATE132863T1 (de) Verfahren zur herstellung von 6-(substituiertes aminopropionyl)-derivaten von forskolin
ATE237553T1 (de) Vorrichtung und verfahren zur produktion von singulett-sauerstoff