DE69025449D1 - Verfahren zur Herstellung von Chenodesoxycholsäuren - Google Patents

Verfahren zur Herstellung von Chenodesoxycholsäuren

Info

Publication number
DE69025449D1
DE69025449D1 DE69025449T DE69025449T DE69025449D1 DE 69025449 D1 DE69025449 D1 DE 69025449D1 DE 69025449 T DE69025449 T DE 69025449T DE 69025449 T DE69025449 T DE 69025449T DE 69025449 D1 DE69025449 D1 DE 69025449D1
Authority
DE
Germany
Prior art keywords
preparation
alpha
acid
alkali metal
chenodeoxycholic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69025449T
Other languages
English (en)
Other versions
DE69025449T2 (de
Inventor
Roberto Arosio
Vittorio Rossetti
Stefano Beratto
Armando Talamona
Emilio Crisafulli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8913570A external-priority patent/FR2653127B1/fr
Priority claimed from FR8913572A external-priority patent/FR2653129B1/fr
Priority claimed from FR8913569A external-priority patent/FR2653126B1/fr
Priority claimed from FR8913571A external-priority patent/FR2653128B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE69025449D1 publication Critical patent/DE69025449D1/de
Publication of DE69025449T2 publication Critical patent/DE69025449T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69025449T 1989-10-17 1990-10-16 Verfahren zur Herstellung von Chenodesoxycholsäuren Expired - Lifetime DE69025449T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8913570A FR2653127B1 (fr) 1989-10-17 1989-10-17 Procede pour la preparation de 12-oxocholanates.
FR8913572A FR2653129B1 (fr) 1989-10-17 1989-10-17 Procede pour la preparation de 7-oxocholanates.
FR8913569A FR2653126B1 (fr) 1989-10-17 1989-10-17 Procede pour la preparation de diacetoxycholanates.
FR8913571A FR2653128B1 (fr) 1989-10-17 1989-10-17 Procede pour la preparation de l'acide chenodesoxycholique.

Publications (2)

Publication Number Publication Date
DE69025449D1 true DE69025449D1 (de) 1996-03-28
DE69025449T2 DE69025449T2 (de) 1996-07-11

Family

ID=27446720

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69025449T Expired - Lifetime DE69025449T2 (de) 1989-10-17 1990-10-16 Verfahren zur Herstellung von Chenodesoxycholsäuren

Country Status (7)

Country Link
EP (1) EP0424232B1 (de)
AT (1) ATE134378T1 (de)
DE (1) DE69025449T2 (de)
DK (1) DK0424232T3 (de)
ES (1) ES2086388T3 (de)
GR (1) GR3019857T3 (de)
IE (1) IE73449B1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2105500A1 (de) 2008-03-26 2009-09-30 Pharmazell GmbH Neue 12alpha-Hydroxysteroiddehydrogenasen, deren Herstellung und deren Verwendung
CN101215311B (zh) * 2008-01-10 2010-10-27 辽宁百隆生物工程有限公司 用含量86%的鹅去氧胆酸生产熊去氧胆酸的生产方法
EP2333101A1 (de) 2009-12-11 2011-06-15 PharmaZell GmbH NAD(P)+-Cofaktorregenerierungssystem und dessen Anwendungen
CN102060902A (zh) * 2011-01-21 2011-05-18 郑州大学 一种鹅去氧胆酸的合成方法
ITMI20110534A1 (it) 2011-03-31 2012-10-01 Prodotti Chimici Alimentari "nuovo processo per l'ossidazione selettiva di acidi biliari, loro sali o derivati"
WO2017207648A1 (en) 2016-05-31 2017-12-07 Bionice, S.L.U Process and intermediates for the preparation of obeticholic acid and derivatives thereof
EP3431486A1 (de) 2017-07-18 2019-01-23 Bionice, S.L.U. Verfahren und zwischenprodukte zur synthese von obeticholsäure und derivaten davon

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
IT1137459B (it) * 1981-04-14 1986-09-10 Erregierre Spa Prodesso per la preparazione di acido ursodeossicolico ad alta purezza
IT1167478B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido ursodesossicolico
FR2511007A1 (fr) * 1981-08-07 1983-02-11 Roussel Uclaf Procede de preparation de l'acide ursodesoxycholique a partir de l'acide 3a, 7b, 12a-trihydroxycholanique et produit intermediaire utilises
JPS5842878B2 (ja) * 1981-12-02 1983-09-22 名糖産業株式会社 １２−オキソコラン酸トシルヒドラゾン化合物、その製法ならびに利用
JPS58155098A (ja) * 1982-03-09 1983-09-14 Yakult Honsha Co Ltd 微生物によるウルソデオキシコ−ル酸の製造法
IT1204429B (it) * 1986-01-09 1989-03-01 Blaschim Spa Riduzione stereoselettiva in acidi biliari

Also Published As

Publication number Publication date
GR3019857T3 (en) 1996-08-31
EP0424232B1 (de) 1996-02-21
ES2086388T3 (es) 1996-07-01
DE69025449T2 (de) 1996-07-11
EP0424232A2 (de) 1991-04-24
DK0424232T3 (da) 1996-06-17
IE903701A1 (en) 1991-04-24
ATE134378T1 (de) 1996-03-15
IE73449B1 (en) 1997-06-04
EP0424232A3 (en) 1992-05-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR