DE69015921D1 - Substituierte aromatische Sulfonamide als Antiglaukomamittel. - Google Patents

Substituierte aromatische Sulfonamide als Antiglaukomamittel.

Info

Publication number
DE69015921D1
DE69015921D1 DE69015921T DE69015921T DE69015921D1 DE 69015921 D1 DE69015921 D1 DE 69015921D1 DE 69015921 T DE69015921 T DE 69015921T DE 69015921 T DE69015921 T DE 69015921T DE 69015921 D1 DE69015921 D1 DE 69015921D1
Authority
DE
Germany
Prior art keywords
substituted aromatic
glaucoma agents
aromatic sulfonamides
sulfonamides
glaucoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69015921T
Other languages
English (en)
Other versions
DE69015921T2 (de
Inventor
John J Baldwin
Gerald S Ponticello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69015921D1 publication Critical patent/DE69015921D1/de
Publication of DE69015921T2 publication Critical patent/DE69015921T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69015921T 1989-07-31 1990-07-27 Substituierte aromatische Sulfonamide als Antiglaukomamittel. Expired - Fee Related DE69015921T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/387,034 US5120757A (en) 1989-07-31 1989-07-31 Substituted aromatic sulfonamides as antiglaucoma agents

Publications (2)

Publication Number Publication Date
DE69015921D1 true DE69015921D1 (de) 1995-02-23
DE69015921T2 DE69015921T2 (de) 1995-06-08

Family

ID=23528163

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69015921T Expired - Fee Related DE69015921T2 (de) 1989-07-31 1990-07-27 Substituierte aromatische Sulfonamide als Antiglaukomamittel.

Country Status (5)

Country Link
US (1) US5120757A (de)
EP (1) EP0411704B1 (de)
JP (1) JP3050397B2 (de)
CA (1) CA2022119C (de)
DE (1) DE69015921T2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
IE911192A1 (en) * 1990-04-12 1991-10-23 Merck & Co Inc Substituted aromatic sulfonamides as antiglaucoma agents
JP3031498B2 (ja) * 1990-04-12 2000-04-10 メルク エンド カムパニー インコーポレーテッド 抗緑内障剤としての置換芳香族スルホンアミド類
EP0480745A3 (en) * 1990-10-12 1992-07-29 Merck & Co. Inc. Substituted dihydrothieno-thiophene-2-sulfonamides and dioxides thereof
CA2080403A1 (en) * 1991-10-15 1993-04-16 John J. Baldwin Tricyclic thienothiopyrans
FR2754712B1 (fr) 1996-10-17 1999-09-03 Merck Sharp Dohme Chibret Lab Compositions ophtalmiques
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
LT5504B (lt) 2006-08-02 2008-06-25 Biotechnologijos Institutas Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824968A (en) * 1984-12-12 1989-04-25 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4677115A (en) * 1984-12-12 1987-06-30 Merck & Co., Inc. Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
CA1320487C (en) * 1987-08-03 1993-07-20 George D. Hartman Substituted thieno[2,3-.beta.]thiophene-2-sulfonamides as antiglaucoma agents
US4946859A (en) * 1989-07-31 1990-08-07 Merck & Co., Inc. 4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrothieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide

Also Published As

Publication number Publication date
JP3050397B2 (ja) 2000-06-12
CA2022119A1 (en) 1991-02-01
CA2022119C (en) 2002-07-02
DE69015921T2 (de) 1995-06-08
JPH03141285A (ja) 1991-06-17
US5120757A (en) 1992-06-09
EP0411704B1 (de) 1995-01-11
EP0411704A1 (de) 1991-02-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee