DE69012636T2 - Verfahren zur Trennung von Makromolekülen. - Google Patents
Verfahren zur Trennung von Makromolekülen.Info
- Publication number
- DE69012636T2 DE69012636T2 DE69012636T DE69012636T DE69012636T2 DE 69012636 T2 DE69012636 T2 DE 69012636T2 DE 69012636 T DE69012636 T DE 69012636T DE 69012636 T DE69012636 T DE 69012636T DE 69012636 T2 DE69012636 T2 DE 69012636T2
- Authority
- DE
- Germany
- Prior art keywords
- separation process
- macromolecule separation
- macromolecule
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
- B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Environmental & Geological Engineering (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34226189A | 1989-04-24 | 1989-04-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69012636D1 DE69012636D1 (de) | 1994-10-27 |
DE69012636T2 true DE69012636T2 (de) | 1995-04-13 |
Family
ID=23341058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69012636T Expired - Fee Related DE69012636T2 (de) | 1989-04-24 | 1990-04-20 | Verfahren zur Trennung von Makromolekülen. |
Country Status (5)
Country | Link |
---|---|
US (2) | US5286434A (de) |
EP (1) | EP0395319B1 (de) |
JP (1) | JPH087185B2 (de) |
CA (1) | CA2012379C (de) |
DE (1) | DE69012636T2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991015758A1 (en) * | 1990-04-11 | 1991-10-17 | Ludwig Institute For Cancer Research | Methods and apparatus allowing sequential chemical reactions |
US5605839A (en) * | 1990-04-11 | 1997-02-25 | Ludwig Institute For Cancer Research | Methods and apparatus for use in sequential chemical reactions |
CA2052037A1 (en) * | 1990-10-02 | 1992-04-03 | Eric Lai | Automatic control system for improved electrophoresis |
US5131994A (en) * | 1990-12-17 | 1992-07-21 | Shmidt Joseph L | Electrophoresis method and apparatus |
US5167784A (en) * | 1991-09-04 | 1992-12-01 | Xerox Corporation | Sequencing large nucleic acid fragments |
US5178737A (en) * | 1991-12-04 | 1993-01-12 | The University Of North Carolina At Chapel Hill | Electrophoretic resolution of single strand DNA by asymmetric field inversion |
DE69427690T2 (de) * | 1993-04-07 | 2002-05-02 | Gradipore Ltd | Verbesserungen im auftrennen von proteinen |
WO1995007363A1 (en) * | 1993-09-10 | 1995-03-16 | Genevue, Inc. | Optical detection of position of oligonucleotides on large dna molecules |
US5938904A (en) * | 1996-03-27 | 1999-08-17 | Curagen Corporation | Separation of charged particles by a spatially and temporally varying electric field |
US6193866B1 (en) | 1996-03-27 | 2001-02-27 | Curagen Corporation | Separation of charged particles by a spatially and temporally varying electric field |
US6146511A (en) * | 1998-01-30 | 2000-11-14 | The Perkin-Elmer Corporation | Electrophoretic nucleic acid purification method |
US7014747B2 (en) * | 2001-06-20 | 2006-03-21 | Sandia Corporation | Dielectrophoretic systems without embedded electrodes |
AU2003234885A1 (en) * | 2002-06-07 | 2003-12-22 | Picosep A/S | Method and system for multi-stage isoelectric focussing |
JP2004184138A (ja) * | 2002-11-29 | 2004-07-02 | Nec Corp | 分離装置、分離方法、および質量分析システム |
CA2586515A1 (en) * | 2003-11-05 | 2005-05-26 | Exact Sciences Corporation | Repetitive reversed-field affinity electrophoresis and uses therefor |
US8518228B2 (en) | 2011-05-20 | 2013-08-27 | The University Of British Columbia | Systems and methods for enhanced SCODA |
WO2005072854A1 (en) | 2004-02-02 | 2005-08-11 | The University Of British Columbia | Scodaphoresis and methods and apparatus for moving and concentrating particles |
US10337054B2 (en) | 2004-02-02 | 2019-07-02 | Quantum-Si Incorporated | Enrichment of nucleic acid targets |
US8529744B2 (en) | 2004-02-02 | 2013-09-10 | Boreal Genomics Corp. | Enrichment of nucleic acid targets |
US9186685B2 (en) | 2012-01-13 | 2015-11-17 | The University Of British Columbia | Multiple arm apparatus and methods for separation of particles |
US7282127B2 (en) * | 2004-04-13 | 2007-10-16 | East Carolina | Microcapillary devices using high dielectric constant materials and related methods |
CA2496294A1 (en) | 2005-02-07 | 2006-08-07 | The University Of British Columbia | Apparatus and methods for concentrating and separating particles such as molecules |
CA2713313A1 (en) | 2008-02-01 | 2009-08-06 | The University Of British Columbia | Methods and apparatus for particle introduction and recovery |
US8877028B2 (en) | 2009-04-21 | 2014-11-04 | The University Of British Columbia | System and methods for detection of particles |
WO2013166444A2 (en) | 2012-05-04 | 2013-11-07 | Boreal Genomics Corp. | Biomarker analysis using scodaphoresis |
CN102879453B (zh) * | 2012-09-04 | 2015-08-26 | 吴传勇 | 基于电泳来操控液体中的带电粒子的方法及器件 |
US9340835B2 (en) | 2013-03-15 | 2016-05-17 | Boreal Genomics Corp. | Method for separating homoduplexed and heteroduplexed nucleic acids |
WO2016185284A1 (en) | 2015-05-20 | 2016-11-24 | Boreal Genomics, Inc. | Method for isolating target nucleic acid using heteroduplex binding proteins |
CA3159566A1 (en) | 2019-10-29 | 2021-05-06 | Quantum-Si Incorporated | Peristaltic pumping of fluids and associated methods, systems, and devices |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1046370B (de) * | 1953-05-22 | 1958-12-11 | Walter J Mach Dipl Ing | Verfahren zur elektrophoresischen Trennung von Stoffgemischen |
US4207166A (en) * | 1971-03-09 | 1980-06-10 | Harald Dahms | Method and apparatus for electrophoresis |
US3948743A (en) * | 1975-04-14 | 1976-04-06 | Bio-Rad Laboratories | Method for gel electrophoresis |
US4059501A (en) * | 1976-08-16 | 1977-11-22 | Beckman Instruments, Inc. | Automated electrophoresis unit |
JPS53144398A (en) * | 1977-05-23 | 1978-12-15 | Olympus Optical Co Ltd | Automatic polarity changing device of power source for electrophoresis |
US4244513A (en) * | 1978-09-15 | 1981-01-13 | Coulter Corporation | Centrifuge unit |
US4433299A (en) * | 1980-03-07 | 1984-02-21 | Kureha Kagaku Kogyo Kabushiki Kaisha | Method and apparatus for measuring interfacial electrokinetic phenomena |
DE3022527C2 (de) * | 1980-06-16 | 1985-01-31 | Fritz Prof. Dr. 7750 Konstanz Pohl | Verfahren zur elektrophoretischen Trennung sowie Vorrichtung dazu |
US4391688A (en) * | 1981-06-02 | 1983-07-05 | Institut Armand-Frappier | Electrophoresis system for multiple agarose slab gels |
JPS589060A (ja) * | 1981-07-09 | 1983-01-19 | Kureha Chem Ind Co Ltd | 電気泳動法による細胞の検査方法 |
US4473452A (en) * | 1982-11-18 | 1984-09-25 | The Trustees Of Columbia University In The City Of New York | Electrophoresis using alternating transverse electric fields |
US4695548A (en) * | 1982-11-18 | 1987-09-22 | The Trustees Of Columbia University In The City Of New York | Gel inserts useful in electrophoresis |
US4441972A (en) * | 1983-04-08 | 1984-04-10 | D.E.P. Systems, Inc. | Apparatus for electrofusion of biological particles |
US4541910A (en) * | 1983-11-07 | 1985-09-17 | Yale University | Method for electroblotting macromolecules from a chromatographic gel |
GB8405601D0 (en) * | 1984-03-02 | 1984-04-04 | Atomic Energy Authority Uk | Electrophoretic separator |
US4545888A (en) * | 1984-04-06 | 1985-10-08 | Walsh J William | Apparatus for electrophoretic recovery of nucleic acids and other substances |
US4794075A (en) * | 1985-08-29 | 1988-12-27 | Lifecodes Corporation | Method for locating and purifying DNA containing single base mismatches |
US4737251A (en) * | 1985-09-27 | 1988-04-12 | Washington University | Field-inversion gel electrophoresis |
US4732656A (en) * | 1985-10-25 | 1988-03-22 | Bios Corporation | Apparatus and process for resolving sample species |
US5106468A (en) * | 1985-12-30 | 1992-04-21 | Exxon Research And Engineering Company | Electrophoretic separation |
US4740283A (en) * | 1986-02-27 | 1988-04-26 | University Patents, Inc. | Pulsed-field gradient gel electrophoretic apparatus |
US4747918A (en) * | 1986-06-18 | 1988-05-31 | William Bellomy | Electroelution apparatus and method of using same |
US4729823A (en) * | 1986-08-08 | 1988-03-08 | Guevara-Kelley Scientific Products, Inc. | Apparatus and methods for electrophoresis |
US4786387A (en) * | 1986-09-25 | 1988-11-22 | Whitlock David R | Single phase enrichment of super critical fluids |
JPH0660887B2 (ja) * | 1987-09-14 | 1994-08-10 | 富士写真フイルム株式会社 | 電気泳動方法 |
EP0320937B1 (de) * | 1987-12-18 | 1996-07-17 | Fuji Photo Film Co., Ltd. | Verfahren zur Elektrophorese |
US4830726A (en) * | 1988-02-03 | 1989-05-16 | The Wistar Institute | Separation of large DNA molecules in alternating asymmetric electric fields |
JPH02176457A (ja) * | 1988-09-15 | 1990-07-09 | Carnegie Inst Of Washington | パルス志向電気泳動 |
-
1990
- 1990-03-16 CA CA002012379A patent/CA2012379C/en not_active Expired - Fee Related
- 1990-04-17 JP JP2101543A patent/JPH087185B2/ja not_active Expired - Fee Related
- 1990-04-20 DE DE69012636T patent/DE69012636T2/de not_active Expired - Fee Related
- 1990-04-20 EP EP90304287A patent/EP0395319B1/de not_active Expired - Lifetime
-
1991
- 1991-10-29 US US07/783,967 patent/US5286434A/en not_active Expired - Fee Related
-
1993
- 1993-11-08 US US08/148,239 patent/US5348636A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0395319B1 (de) | 1994-09-21 |
CA2012379C (en) | 2000-01-25 |
JPH0341355A (ja) | 1991-02-21 |
US5348636A (en) | 1994-09-20 |
CA2012379A1 (en) | 1990-10-24 |
EP0395319A1 (de) | 1990-10-31 |
JPH087185B2 (ja) | 1996-01-29 |
US5286434A (en) | 1994-02-15 |
DE69012636D1 (de) | 1994-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |