DE69007900D1 - 4,4-Disubstituierte Piperidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen. - Google Patents

4,4-Disubstituierte Piperidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.

Info

Publication number
DE69007900D1
DE69007900D1 DE90308782T DE69007900T DE69007900D1 DE 69007900 D1 DE69007900 D1 DE 69007900D1 DE 90308782 T DE90308782 T DE 90308782T DE 69007900 T DE69007900 T DE 69007900T DE 69007900 D1 DE69007900 D1 DE 69007900D1
Authority
DE
Germany
Prior art keywords
alkyl
compounds
processes
preparation
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90308782T
Other languages
English (en)
Other versions
DE69007900T2 (de
Inventor
Edit Toth
Jozsef Toerley
Sandor Dr Goeroeg
Laszlo Dr Szporny
Bela Kiss
Eva Dr Palosi
Dora Dr Groo
Istvan Dr Laszlovszky
Erzsebet Dr Lapis
Ferenc Auth
Laszlo Dr Gaal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU894094A external-priority patent/HU204276B/hu
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of DE69007900D1 publication Critical patent/DE69007900D1/de
Publication of DE69007900T2 publication Critical patent/DE69007900T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69007900T 1989-08-10 1990-08-09 4,4-Disubstituierte Piperidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen. Expired - Fee Related DE69007900T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU894094A HU204276B (en) 1989-08-10 1989-08-10 Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
HU323390 1990-05-29

Publications (2)

Publication Number Publication Date
DE69007900D1 true DE69007900D1 (de) 1994-05-11
DE69007900T2 DE69007900T2 (de) 1994-07-21

Family

ID=26317611

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69007900T Expired - Fee Related DE69007900T2 (de) 1989-08-10 1990-08-09 4,4-Disubstituierte Piperidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.

Country Status (12)

Country Link
US (1) US5118693A (de)
EP (1) EP0412822B1 (de)
JP (1) JPH0377866A (de)
KR (1) KR940003491B1 (de)
AT (1) ATE103896T1 (de)
AU (1) AU624261B2 (de)
DD (1) DD299425A5 (de)
DE (1) DE69007900T2 (de)
DK (1) DK0412822T3 (de)
ES (1) ES2063282T3 (de)
IL (1) IL95323A (de)
NZ (1) NZ234847A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204530B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
WO2002046156A2 (en) 2000-12-06 2002-06-13 Sepracor, Inc. 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838518A (en) * 1953-12-24 1958-06-10 Degussa Ethynyl piperidyl carbamic acid esters
DE1137438B (de) * 1955-08-27 1962-10-04 Degussa Verfahren zur Herstellung von sedativ bzw. hypnotisch wirksamen Carbaminsaeureestern
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL95323A0 (en) 1991-06-30
DE69007900T2 (de) 1994-07-21
KR940003491B1 (ko) 1994-04-23
US5118693A (en) 1992-06-02
EP0412822B1 (de) 1994-04-06
AU624261B2 (en) 1992-06-04
IL95323A (en) 1994-06-24
AU6080690A (en) 1991-02-14
KR910004563A (ko) 1991-03-28
NZ234847A (en) 1994-05-26
EP0412822A2 (de) 1991-02-13
JPH0377866A (ja) 1991-04-03
DD299425A5 (de) 1992-04-16
EP0412822A3 (en) 1991-11-27
ATE103896T1 (de) 1994-04-15
DK0412822T3 (da) 1994-05-16
ES2063282T3 (es) 1995-01-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee