DE69007631D1 - Anti-infektiöse und gleitfähige medizinische Gegenstände und Verfahren zu deren Herstellung. - Google Patents

Anti-infektiöse und gleitfähige medizinische Gegenstände und Verfahren zu deren Herstellung.

Info

Publication number
DE69007631D1
DE69007631D1 DE90300005T DE69007631T DE69007631D1 DE 69007631 D1 DE69007631 D1 DE 69007631D1 DE 90300005 T DE90300005 T DE 90300005T DE 69007631 T DE69007631 T DE 69007631T DE 69007631 D1 DE69007631 D1 DE 69007631D1
Authority
DE
Germany
Prior art keywords
chlorhexidine
infectious
manufacture
processes
base layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE90300005T
Other languages
English (en)
Other versions
DE69007631T2 (de
Inventor
Donald D Solomon
Parke M Byron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Application granted granted Critical
Publication of DE69007631D1 publication Critical patent/DE69007631D1/de
Publication of DE69007631T2 publication Critical patent/DE69007631T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206—Biguanides, e.g. chlorohexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Laminated Bodies (AREA)
  • Medicinal Preparation (AREA)
DE69007631T 1989-01-18 1990-01-02 Anti-infektiöse und gleitfähige medizinische Gegenstände und Verfahren zu deren Herstellung. Expired - Lifetime DE69007631T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29839289A 1989-01-18 1989-01-18

Publications (2)

Publication Number Publication Date
DE69007631D1 true DE69007631D1 (de) 1994-05-05
DE69007631T2 DE69007631T2 (de) 1994-08-25

Family

ID=23150303

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69007631T Expired - Lifetime DE69007631T2 (de) 1989-01-18 1990-01-02 Anti-infektiöse und gleitfähige medizinische Gegenstände und Verfahren zu deren Herstellung.

Country Status (7)

Country Link
EP (1) EP0379269B1 (de)
JP (1) JPH02234767A (de)
AT (1) ATE103497T1 (de)
CA (1) CA2004366C (de)
DE (1) DE69007631T2 (de)
ES (1) ES2054229T3 (de)
IE (1) IE64997B1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95816C (fi) 1989-05-04 1996-03-25 Ad Tech Holdings Ltd Antimikrobinen esine ja menetelmä sen valmistamiseksi
US5328698A (en) * 1990-08-06 1994-07-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic and/or anti-infective
FR2679142B1 (fr) * 1991-07-18 1995-06-09 Nice Sophia Antipolis Universi Procede de protection des protheses, des materiaux implantables provisoires ou definitifs contre la colonisation et l'infection bacterienne.
GB2270845B (en) * 1992-09-24 1996-07-10 Smiths Ind Med Syst Inc Suction catheter assemblies
EG20321A (en) * 1993-07-21 1998-10-31 Otsuka Pharma Co Ltd Medical material and process for producing the same
US20070161968A1 (en) * 1996-06-04 2007-07-12 Vance Products Inc., Dba Cood Urological Inc. Implantable medical device with pharmacologically active ingredient
US6273875B1 (en) 1998-08-17 2001-08-14 Edwards Lifesciences Corporation Medical devices having improved antimicrobial/antithrombogenic properties
US6596401B1 (en) 1998-11-10 2003-07-22 C. R. Bard Inc. Silane copolymer compositions containing active agents
GB2349644A (en) 1999-05-01 2000-11-08 Biointeractions Ltd Infection resistant polymers, methods for their preparation, and their uses
US6716895B1 (en) 1999-12-15 2004-04-06 C.R. Bard, Inc. Polymer compositions containing colloids of silver salts
US7179849B2 (en) 1999-12-15 2007-02-20 C. R. Bard, Inc. Antimicrobial compositions containing colloids of oligodynamic metals
US6579539B2 (en) 1999-12-22 2003-06-17 C. R. Bard, Inc. Dual mode antimicrobial compositions
GB0103668D0 (en) * 2001-02-15 2001-03-28 Biointeractions Ltd Methods and clinical devices for the inhibition or prevention of mammalian cell growth
ATE357138T1 (de) 2001-11-21 2007-04-15 Altachem Pharma Ltd Antipathogenische zusammensetzung verwendbar in der konservierung von blut
US20030100829A1 (en) * 2001-11-27 2003-05-29 Sheng-Ping Zhong Medical devices with magnetic resonance visibility enhancing material
MXPA04005332A (es) 2001-12-03 2005-05-16 Bard Inc C R Dispositivo medico resistente a microbios, revestimiento polimerico resistente a microbios y metodos para producir los mismos.
DK1509256T3 (da) * 2002-05-24 2009-11-23 Angiotech Int Ag Præparater og fremgangsmåde til coating af medicinske implantater
US20040220534A1 (en) * 2003-04-29 2004-11-04 Martens Paul W. Medical device with antimicrobial layer
JP2008023070A (ja) * 2006-07-21 2008-02-07 Kaneka Corp 医療用ドレーンチューブならびにその製造方法
US20100087788A1 (en) * 2006-10-18 2010-04-08 Joel Rosenblatt Anti-infective alcohol catheter solution with chlorhexidine treated catheter
US8895047B2 (en) * 2007-06-01 2014-11-25 Arrow International, Inc. Combined fibrinolytic and antimicrobial catheter and uses thereof
US20100069854A1 (en) * 2008-09-12 2010-03-18 Onajite Okoh Elastomeric Devices Containing Chlorhexidine/Fatty Acid Salts Made From Fatty Acids of 12 to 18 Carbons
EP2373270B8 (de) 2009-01-07 2023-04-12 entrotech life sciences, inc. Chlorhexidinhaltige antimikrobielle beschichtungen
US20100234815A1 (en) * 2009-03-11 2010-09-16 Teleflex Medical Incorporated Stable melt processable chlorhexidine compositions
US20100233288A1 (en) * 2009-03-11 2010-09-16 Teleflex Medical Incorporated Medical devices containing nitroprusside and antimicrobial agents
US11219706B2 (en) 2009-03-11 2022-01-11 Arrow International Llc Enhanced formulations for coating medical devices
DE102009052721A1 (de) 2009-11-12 2011-05-26 B. Braun Melsungen Ag Verwendung polymerer oder oligomerer Wirkstoffe für medizinische Artikel
DE102009052725A1 (de) 2009-11-12 2011-05-19 B. Braun Melsungen Ag Verwendung von Polyoxyalkylendiamin-basierten Polyguanidinderivaten für medizinische Artikel
US20120150131A1 (en) * 2010-12-09 2012-06-14 Teleflex Medical Incorporated Polymer for Controlling Delivery of Bioactive Agents and Method of Use
US10792398B2 (en) 2014-02-20 2020-10-06 Becton, Dickinson And Company Antimicrobial inserts for medical devices
US10792399B2 (en) 2014-02-20 2020-10-06 Becton, Dickinson And Company Antimicrobial inserts for medical devices
WO2015161302A1 (en) 2014-04-18 2015-10-22 Entrotech Life Sciences, Inc. Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby
US10149971B2 (en) 2014-04-23 2018-12-11 Becton, Dickinson And Company Antimicrobial stopcock medical connector
US10004890B2 (en) 2015-01-27 2018-06-26 Becton, Dickinson And Company Antimicrobial inserts for stopcock medical connectors
CN104874028A (zh) * 2015-04-10 2015-09-02 南京天朗制药有限公司 一种超滑抗菌导尿管及其制备方法
KR20230117758A (ko) * 2017-01-30 2023-08-09 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 항균성의 비-응혈성 폴리머 조성물
CA3239933A1 (en) * 2021-12-30 2023-07-06 Nisha Gupta Compounded active pharmaceutical agents in thermoplastic polymer compositions and methods of manufacture

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US4343788A (en) * 1979-06-29 1982-08-10 The Procter & Gamble Company Antimicrobial polymer compositions
GB2084466B (en) * 1980-10-06 1984-07-11 Mcnally Ronald Biocidal material
JPS59228856A (ja) * 1983-06-10 1984-12-22 ユニチカ株式会社 抗菌剤徐放性導尿カテ−テル
US4675347A (en) * 1983-10-29 1987-06-23 Unitika Ltd. Antimicrobial latex composition
JPH0611813B2 (ja) * 1983-10-29 1994-02-16 ユニチカ株式会社 抗菌性ラテツクス組成物
JPS6096258A (ja) * 1983-10-29 1985-05-29 ユニチカ株式会社 抗菌剤徐放性成形品の製造法
US4581028A (en) * 1984-04-30 1986-04-08 The Trustees Of Columbia University In The City Of New York Infection-resistant materials and method of making same through use of sulfonamides
SE8405504L (sv) * 1984-11-02 1986-05-03 Johan Brohult Plastforemal
US4676975A (en) * 1984-12-07 1987-06-30 Becton, Dickinson And Company Thermoplastic polyurethane anticoagulant alloy coating
US4678660A (en) * 1984-12-07 1987-07-07 Deseret Medical, Inc. Thermoplastic polyurethane anticoagulant alloy coating
AU579375B2 (en) * 1984-12-12 1988-11-24 C.R. Bard Inc. An improved device and method
ATE88324T1 (de) * 1984-12-28 1993-05-15 Johnson Matthey Plc Antimikrobielle zusammensetzungen.
JPS6320344A (ja) * 1986-07-14 1988-01-28 Sumitomo Electric Ind Ltd 抗菌剤徐放性樹脂組成物
FR2623712B1 (fr) * 1987-11-30 1991-05-03 Yakoun Maurice Element prophylactique anti-infectieux local ou regional a usage medical et veterinaire

Also Published As

Publication number Publication date
ATE103497T1 (de) 1994-04-15
EP0379269A3 (en) 1990-12-05
JPH0523790B2 (de) 1993-04-05
CA2004366C (en) 1996-08-27
DE69007631T2 (de) 1994-08-25
IE64997B1 (en) 1995-10-04
EP0379269B1 (de) 1994-03-30
JPH02234767A (ja) 1990-09-17
IE893704L (en) 1990-07-18
ES2054229T3 (es) 1994-08-01
CA2004366A1 (en) 1990-07-18
EP0379269A2 (de) 1990-07-25

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