DE69003213D1 - Imidazol-Derivate als Histamin-H3-Agonisten. - Google Patents

Imidazol-Derivate als Histamin-H3-Agonisten.

Info

Publication number
DE69003213D1
DE69003213D1 DE90307998T DE69003213T DE69003213D1 DE 69003213 D1 DE69003213 D1 DE 69003213D1 DE 90307998 T DE90307998 T DE 90307998T DE 69003213 T DE69003213 T DE 69003213T DE 69003213 D1 DE69003213 D1 DE 69003213D1
Authority
DE
Germany
Prior art keywords
histamine
agonists
imidazole derivatives
imidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90307998T
Other languages
English (en)
Other versions
DE69003213T2 (de
Inventor
William Howson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of DE69003213D1 publication Critical patent/DE69003213D1/de
Application granted granted Critical
Publication of DE69003213T2 publication Critical patent/DE69003213T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE90307998T 1989-07-25 1990-07-20 Imidazol-Derivate als Histamin-H3-Agonisten. Expired - Fee Related DE69003213T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898916947A GB8916947D0 (en) 1989-07-25 1989-07-25 Medicaments

Publications (2)

Publication Number Publication Date
DE69003213D1 true DE69003213D1 (de) 1993-10-14
DE69003213T2 DE69003213T2 (de) 1994-01-05

Family

ID=10660573

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90307998T Expired - Fee Related DE69003213T2 (de) 1989-07-25 1990-07-20 Imidazol-Derivate als Histamin-H3-Agonisten.

Country Status (5)

Country Link
US (1) US5047418A (de)
EP (1) EP0420396B1 (de)
JP (1) JPH0358924A (de)
DE (1) DE69003213T2 (de)
GB (1) GB8916947D0 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5321039A (en) * 1990-04-13 1994-06-14 Societe Civile Bioprojet Method of inducing a histamine agonist action on H2 receptors
FR2660862B1 (fr) * 1990-04-13 1994-09-23 Bioprojet Soc Civ Application therapeutique de derives de l'histamine, nouveau derive de l'histamine et utilisation de ces derives pour la preparation de medicaments.
NL9100365A (nl) * 1991-02-27 1992-09-16 Seed Capital Investments Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
GB9115740D0 (en) * 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
SI9300616A (en) * 1992-11-27 1994-06-30 Wellcome Found Enzyme inhibitors
EP0729459B1 (de) * 1993-11-15 2003-03-12 Schering Corporation Phenylalkyl-imidazole als h3-rezeptor-antagonisten
US6133291A (en) * 1998-10-16 2000-10-17 Schering Corporation N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists
US6211182B1 (en) 1999-03-08 2001-04-03 Schering Corporation Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
DE60136284D1 (de) 2000-09-20 2008-12-04 Schering Corp Substituierte imidazole als histamine h1 und h3 agonisten oder antagonisten
AR030946A1 (es) 2000-09-20 2003-09-03 Schering Corp Derivados de imidazoles sustituidos un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos como agonistas o antagonistas duales de h1 y h3 de histamina
DE60135471D1 (de) 2000-09-20 2008-10-02 Schering Corp H3 agonisten oder antagonisten
ATE283853T1 (de) 2000-09-20 2004-12-15 Schering Corp Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten
CA2436083A1 (en) 2001-02-08 2002-09-19 Schering Corporation Use of dual h3/m2 antagonists in the treatment of cognition deficit disorders
US20100137391A1 (en) * 2005-09-15 2010-06-03 Ryo Yoshimoto Histamine H3 Agonist for use as Therapeutic Agent for a Lipid/Glucose Metabolic Disorder
CN103288742A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种高纯度英加韦林原料的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891764A (en) * 1969-10-29 1975-06-24 Smith Kline French Lab Method of inhibiting histamine activity with amidine derivatives
US3759944A (en) * 1970-10-14 1973-09-18 Smith Kline French Lab Isothioureas and their derivatives
US4000302A (en) * 1972-04-20 1976-12-28 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
GB1399283A (en) * 1972-04-20 1975-07-02 Smith Kline French Lab Pharmaceutical compositions
US3954982A (en) * 1972-04-20 1976-05-04 Smith Kline & French Laboratories Limited Pharmaceutical compositions and method of inhibiting H-1 and H-2 histamine receptors

Also Published As

Publication number Publication date
US5047418A (en) 1991-09-10
JPH0358924A (ja) 1991-03-14
EP0420396A2 (de) 1991-04-03
GB8916947D0 (en) 1989-09-13
DE69003213T2 (de) 1994-01-05
EP0420396B1 (de) 1993-09-08
EP0420396A3 (en) 1991-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee