DE69001649T2 - Verfahren zur Durchführung von nucleophilen Substitutionen. - Google Patents

Verfahren zur Durchführung von nucleophilen Substitutionen.

Info

Publication number
DE69001649T2
DE69001649T2 DE90401739T DE69001649T DE69001649T2 DE 69001649 T2 DE69001649 T2 DE 69001649T2 DE 90401739 T DE90401739 T DE 90401739T DE 69001649 T DE69001649 T DE 69001649T DE 69001649 T2 DE69001649 T2 DE 69001649T2
Authority
DE
Germany
Prior art keywords
procedure
nucleophilic substitutions
performing nucleophilic
catalyst
sulphotriphenylphosphine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90401739T
Other languages
English (en)
Other versions
DE69001649D1 (de
Inventor
Denis Sinou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of DE69001649D1 publication Critical patent/DE69001649D1/de
Application granted granted Critical
Publication of DE69001649T2 publication Critical patent/DE69001649T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B01J2231/4277—C-X Cross-coupling, e.g. nucleophilic aromatic amination, alkoxylation or analogues
    • B01J2231/4283—C-X Cross-coupling, e.g. nucleophilic aromatic amination, alkoxylation or analogues using N nucleophiles, e.g. Buchwald-Hartwig amination
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/48—Ring-opening reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/90—Catalytic systems characterized by the solvent or solvent system used
    • B01J2531/96—Water
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/584—Recycling of catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
DE90401739T 1989-06-22 1990-06-20 Verfahren zur Durchführung von nucleophilen Substitutionen. Expired - Fee Related DE69001649T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8908318A FR2652514A1 (fr) 1989-06-22 1989-06-22 Nouveau catalyseur a base de palladium et son emploi.

Publications (2)

Publication Number Publication Date
DE69001649D1 DE69001649D1 (de) 1993-06-24
DE69001649T2 true DE69001649T2 (de) 1993-10-07

Family

ID=9383018

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90401739T Expired - Fee Related DE69001649T2 (de) 1989-06-22 1990-06-20 Verfahren zur Durchführung von nucleophilen Substitutionen.

Country Status (10)

Country Link
US (1) US5135900A (de)
EP (1) EP0407256B1 (de)
JP (1) JPH03232535A (de)
AT (1) ATE89495T1 (de)
CA (1) CA2019495A1 (de)
DE (1) DE69001649T2 (de)
DK (1) DK0407256T3 (de)
ES (1) ES2055361T3 (de)
FR (1) FR2652514A1 (de)
GR (1) GR3007916T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69128175T2 (de) * 1990-08-02 1998-05-20 Rhone Poulenc Chimie Allylierungsreagens und ein es verwendendes Herstellungsverfahren
US5366663A (en) * 1991-11-30 1994-11-22 Hoechst Ag Mixtures of liquid crystalline copolymers, polyether imides and compatibilizers and use thereof
AU670261B2 (en) * 1992-04-15 1996-07-11 Rhone-Poulenc Chimie Reagent and catalytic process useful for cleaving a protected functional group
FR2690153A1 (fr) * 1992-04-15 1993-10-22 Rhone Poulenc Chimie Réactif et procédé catalytique utile pour cliver une fonction protégée.
FR2703688B1 (fr) * 1993-04-09 1995-05-19 Rhone Poulenc Chimie Réactif de désallylation, procédé de désallylation utilisant ledit réactif.
US10882035B2 (en) * 2016-05-10 2021-01-05 Promega Corporation Palladium catalysts with improved performance in biological environments
CN112473748B (zh) * 2020-12-24 2021-09-17 北京交通大学 一种可控氧化的四三苯基膦钯催化剂及其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2366237A1 (fr) * 1976-07-27 1978-04-28 Rhone Poulenc Ind Procede de telomerisation de dienes
US4243829A (en) * 1976-10-04 1981-01-06 Charles U. Pittman, Jr. Production of 1,7-octadiene from butadiene
US4229606A (en) * 1978-12-13 1980-10-21 Shell Oil Company 1,7-Octadiene process
GB2074156B (en) * 1980-03-28 1984-02-29 Kuraray Co Preparation of n-octadienol
GB2085874B (en) * 1980-09-04 1984-08-08 Johnson Matthey Plc Hydroformylation of olefins
US4362670A (en) * 1981-09-03 1982-12-07 The Dow Chemical Company Allylation of carbon compounds
FR2549840B1 (fr) * 1983-07-28 1986-03-21 Rhone Poulenc Sante Nouvelles phosphines chirales sulfonees, leur preparation et leur emploi en catalyse asymetrique
FR2596390B1 (fr) * 1986-03-27 1989-02-17 Rhone Poulenc Chimie Procede de (co)dimerisation catalytique d'un acrylate d'alkyle inferieur et composition catalytique
EP0287066B1 (de) * 1987-04-16 1993-09-22 Kuraray Co., Ltd. Verfahren zur kontinuierlichen Herstellung von Octa-2,7-dien-1-ol
FR2617163B1 (fr) * 1987-06-23 1992-04-30 Strasbourg I Universite Procede de preparation de la lactone ethylidene-2 heptene-6 olide-5, par telomerisation du butadiene et du dioxyde de carbone
GB8723602D0 (en) * 1987-10-08 1987-11-11 British Petroleum Co Plc Polyketones
JPH02240040A (ja) * 1989-03-13 1990-09-25 Nippon Zeon Co Ltd ３―ケト―１―アルコールの製造法

Also Published As

Publication number Publication date
CA2019495A1 (fr) 1990-12-22
EP0407256A1 (de) 1991-01-09
DK0407256T3 (da) 1993-06-14
ATE89495T1 (de) 1993-06-15
EP0407256B1 (de) 1993-05-19
ES2055361T3 (es) 1994-08-16
GR3007916T3 (de) 1993-08-31
JPH03232535A (ja) 1991-10-16
US5135900A (en) 1992-08-04
DE69001649D1 (de) 1993-06-24
FR2652514A1 (fr) 1991-04-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee