DE69001146D1 - Koenzym q10 mit hmg-coa-reduktase-inhibitoren. - Google Patents

Koenzym q10 mit hmg-coa-reduktase-inhibitoren.

Info

Publication number
DE69001146D1
DE69001146D1 DE9090300476T DE69001146T DE69001146D1 DE 69001146 D1 DE69001146 D1 DE 69001146D1 DE 9090300476 T DE9090300476 T DE 9090300476T DE 69001146 T DE69001146 T DE 69001146T DE 69001146 D1 DE69001146 D1 DE 69001146D1
Authority
DE
Germany
Prior art keywords
koenzym
hmg
coa reductase
reductase inhibitors
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE9090300476T
Other languages
English (en)
Other versions
DE69001146T2 (de
Inventor
Michael S Brown
Jonathan A Tobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/298,535 external-priority patent/US4933165A/en
Priority claimed from US07/305,140 external-priority patent/US4929437A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69001146D1 publication Critical patent/DE69001146D1/de
Application granted granted Critical
Publication of DE69001146T2 publication Critical patent/DE69001146T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
DE90300476T 1989-01-18 1990-01-17 Koenzym Q10 mit HMG-COA-Reduktase-Inhibitoren. Expired - Fee Related DE69001146T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/298,535 US4933165A (en) 1989-01-18 1989-01-18 Coenzyme Q10 with HMG-CoA reductase inhibitors
US07/305,140 US4929437A (en) 1989-02-02 1989-02-02 Coenzyme Q10 with HMG-CoA reductase inhibitors

Publications (2)

Publication Number Publication Date
DE69001146D1 true DE69001146D1 (de) 1993-04-29
DE69001146T2 DE69001146T2 (de) 1993-10-07

Family

ID=26970727

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90300476T Expired - Fee Related DE69001146T2 (de) 1989-01-18 1990-01-17 Koenzym Q10 mit HMG-COA-Reduktase-Inhibitoren.

Country Status (4)

Country Link
EP (1) EP0383432B1 (de)
JP (1) JPH02233611A (de)
CA (1) CA2007983C (de)
DE (1) DE69001146T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100725263B1 (ko) * 1999-06-08 2007-06-07 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. ＨＭＧ-ＣｏＡ 리덕타제 억제제 및 카르니틴을 포함하는 항지질혈성 복합제
ES2237073T3 (es) * 1999-06-30 2005-07-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Combinacion con actividad hipolipemiante sustancialmente exenta de efectos toxicos o secundarios inducidos por farmacos hipolimiantes.
US8753675B1 (en) * 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications
EP1285650B1 (de) * 2000-05-09 2016-07-27 Kaneka Corporation Methoden und zusammensetzungen zur arterioskleroseinhibition
AUPR177300A0 (en) * 2000-11-29 2000-12-21 Centre For Molecular Biology And Medicine Therapeutic methods
AUPR951101A0 (en) * 2001-12-13 2002-01-24 Centre For Molecular Biology And Medicine Method of treatment
ITRM20040307A1 (it) 2004-06-23 2004-09-23 Sigma Tau Ind Farmaceuti Confezione per almeno due prodotti differenti da vendere e utilizzare insieme.
WO2006057209A1 (ja) * 2004-11-26 2006-06-01 Sankyo Company, Limited 血中遊離脂肪酸低下作用を有する医薬組成物
JP4896501B2 (ja) * 2004-11-26 2012-03-14 第一三共株式会社 血中遊離脂肪酸低下作用を有する医薬組成物
US20080160001A1 (en) * 2005-03-28 2008-07-03 Pficker Pharmaceuticals Ltd. Antihypercholesterolemic Formulation with Less Side-Effects
TW200722077A (en) * 2005-03-29 2007-06-16 Kaneka Corp Composition for enhancing expression and activity of protease in liver
CN101491550B (zh) * 2008-01-22 2011-12-28 沈阳皓天万嘉医药科技有限公司 一种红曲提取物与辅酶q10复方制剂的制备方法
HUE042168T2 (hu) * 2008-02-29 2019-06-28 Biolab Sanus Farmaceutica Ltda Racetámot és karnitint tartalmazó gyógyszerkészítmény és eljárás elõállítására
US8557236B2 (en) 2010-02-09 2013-10-15 Vascure Natural LLC Cardiovascular support supplement and compositions and methods thereof
EP2815654A1 (de) 2013-06-21 2014-12-24 Essential IP BV Zusammensetzung mit günstiger Wirkung auf das kardiovaskuläre System, welche Monacolin K, Lycopin und Vitamin D3 enthält

Also Published As

Publication number Publication date
EP0383432B1 (de) 1993-03-24
DE69001146T2 (de) 1993-10-07
CA2007983A1 (en) 1990-07-18
CA2007983C (en) 1996-12-10
JPH02233611A (ja) 1990-09-17
EP0383432A1 (de) 1990-08-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee