DE68922297T2 - Für das menschliche angiotension-umformungsenzym (ace) kodierende nukleinsäure und ihre anwendungen, insbesondere zur in-vitro-diagnose von bluthochdruck. - Google Patents

Für das menschliche angiotension-umformungsenzym (ace) kodierende nukleinsäure und ihre anwendungen, insbesondere zur in-vitro-diagnose von bluthochdruck.

Info

Publication number
DE68922297T2
DE68922297T2 DE68922297T DE68922297T DE68922297T2 DE 68922297 T2 DE68922297 T2 DE 68922297T2 DE 68922297 T DE68922297 T DE 68922297T DE 68922297 T DE68922297 T DE 68922297T DE 68922297 T2 DE68922297 T2 DE 68922297T2
Authority
DE
Germany
Prior art keywords
ace
nucleic acid
human
angiotension
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922297T
Other languages
English (en)
Other versions
DE68922297D1 (de
Inventor
Florent Soubrier
Francois Alhenc-Gelas
Christine Hubert
Pierre Corvol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Application granted granted Critical
Publication of DE68922297D1 publication Critical patent/DE68922297D1/de
Publication of DE68922297T2 publication Critical patent/DE68922297T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE68922297T 1988-09-27 1989-09-27 Für das menschliche angiotension-umformungsenzym (ace) kodierende nukleinsäure und ihre anwendungen, insbesondere zur in-vitro-diagnose von bluthochdruck. Expired - Fee Related DE68922297T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8812620A FR2636968B1 (fr) 1988-09-27 1988-09-27 Acide nucleique codant pour l'enzyme de conversion de l'angiotensine (eca) humaine, et ses applications, notamment pour le diagnostic in vitro de l'hypertension arterielle
PCT/FR1989/000496 WO1990003435A2 (fr) 1988-09-27 1989-09-27 Acide nucleique codant pour l'enzyme de conversion de l'angiotensine (eca) humaine, et ses applications, notamment pour le diagnostic in vitro de l'hypertension arterielle

Publications (2)

Publication Number Publication Date
DE68922297D1 DE68922297D1 (de) 1995-05-24
DE68922297T2 true DE68922297T2 (de) 1995-09-14

Family

ID=9370447

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922297T Expired - Fee Related DE68922297T2 (de) 1988-09-27 1989-09-27 Für das menschliche angiotension-umformungsenzym (ace) kodierende nukleinsäure und ihre anwendungen, insbesondere zur in-vitro-diagnose von bluthochdruck.

Country Status (7)

Country Link
US (2) US5359045A (de)
EP (1) EP0388466B1 (de)
JP (1) JP2854062B2 (de)
AT (1) ATE121457T1 (de)
DE (1) DE68922297T2 (de)
FR (1) FR2636968B1 (de)
WO (1) WO1990003435A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678285A1 (fr) * 1991-06-27 1992-12-31 Inst Nat Sante Rech Med Moyens et procedes pour l'etude du polymorphisme genetique de l'enzyme de conversion de l'angiotensine 1.
WO1997003196A1 (en) 1995-07-11 1997-01-30 Magainin Pharmaceuticals Inc. CLONING, TISSUE DISTRIBUTION, AND FUNCTIONAL ANALYSIS OF Na+/H+ EXCHANGER ISOFORM, NHE3
US5800990A (en) * 1995-12-06 1998-09-01 Regents Of The University Of Colorado Angiotensin-converting enzyme genetic variant screens
AU740021B2 (en) * 1996-10-04 2001-10-25 Stephen J. Fey Hypertension markers
US6376182B1 (en) 1997-05-14 2002-04-23 Medical University Of South Carolina Methods and compositions for correlating tissue kallikrein gene promoter polymorphisms with treatment of essential hypertension
US5948616A (en) * 1997-05-14 1999-09-07 Musc Foundation For Research Development Methods and compositions of correlating tissue kallikrein gene promoter polymorphisms with essential hypertension
US6194556B1 (en) 1997-12-11 2001-02-27 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
US6610497B1 (en) * 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6989363B1 (en) 1997-12-11 2006-01-24 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6525185B1 (en) * 1998-05-07 2003-02-25 Affymetrix, Inc. Polymorphisms associated with hypertension
WO2000020032A1 (en) * 1998-10-06 2000-04-13 Trustees Of Dartmouth College RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
AU4691900A (en) * 1999-05-13 2000-12-05 Zymogenetics Inc. Zace2: a human metalloenzyme
AU1410801A (en) * 1999-11-17 2001-05-30 Compugen Ltd. Variants of alternative splicing
JP2003521910A (ja) * 2000-02-11 2003-07-22 ザ スキーペンズ アイ リサーチ インスティテュート インコーポレイテッド 網膜幹細胞の分離及び移植
US7514213B2 (en) * 2002-11-15 2009-04-07 Quest Diagnostics Investments Incorporated Compositions and methods for determining genotypes
US20090217402A1 (en) * 2005-05-20 2009-08-27 Emory University Methods and compositions for modulating the activity of peptidases in macrophage and macrophage-like cells
NZ576349A (en) * 2006-09-18 2012-09-28 Univ Sydney Equine performance test
US10758572B2 (en) 2012-02-17 2020-09-01 The Schepens Eye Research Institute Phenotype profile of human retinal progenitor cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
JPS61186399A (ja) * 1984-07-30 1986-08-20 Fuji Yakuhin Kogyo Kk 抗ヒトアンジオテンシン変換酵素抗体

Also Published As

Publication number Publication date
US5359045A (en) 1994-10-25
JP2854062B2 (ja) 1999-02-03
EP0388466A1 (de) 1990-09-26
FR2636968A1 (fr) 1990-03-30
WO1990003435A2 (fr) 1990-04-05
ATE121457T1 (de) 1995-05-15
EP0388466B1 (de) 1995-04-19
FR2636968B1 (fr) 1992-01-03
WO1990003435A3 (fr) 1990-05-31
DE68922297D1 (de) 1995-05-24
JPH03502643A (ja) 1991-06-20
US5480793A (en) 1996-01-02

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