DE68903596T2 - Verfahren zur herstellung von 2-(difluormethoxy)-1,1,1,2-tetrafluorethan. - Google Patents
Verfahren zur herstellung von 2-(difluormethoxy)-1,1,1,2-tetrafluorethan.Info
- Publication number
- DE68903596T2 DE68903596T2 DE8989304363T DE68903596T DE68903596T2 DE 68903596 T2 DE68903596 T2 DE 68903596T2 DE 8989304363 T DE8989304363 T DE 8989304363T DE 68903596 T DE68903596 T DE 68903596T DE 68903596 T2 DE68903596 T2 DE 68903596T2
- Authority
- DE
- Germany
- Prior art keywords
- isoflurane
- reaction
- bromine trifluoride
- brf3
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- DPYMFVXJLLWWEU-UHFFFAOYSA-N desflurane Chemical compound FC(F)OC(F)C(F)(F)F DPYMFVXJLLWWEU-UHFFFAOYSA-N 0.000 title claims description 11
- 238000004519 manufacturing process Methods 0.000 title 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 claims description 29
- 238000006243 chemical reaction Methods 0.000 claims description 29
- 229960002725 isoflurane Drugs 0.000 claims description 28
- FQFKTKUFHWNTBN-UHFFFAOYSA-N trifluoro-$l^{3}-bromane Chemical compound FBr(F)F FQFKTKUFHWNTBN-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 description 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000003518 caustics Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000004293 19F NMR spectroscopy Methods 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 101100311330 Schizosaccharomyces pombe (strain 972 / ATCC 24843) uap56 gene Proteins 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 1
- 101150018444 sub2 gene Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/04—Saturated ethers
- C07C43/12—Saturated ethers containing halogen
- C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19097188A | 1988-05-06 | 1988-05-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68903596D1 DE68903596D1 (de) | 1993-01-07 |
| DE68903596T2 true DE68903596T2 (de) | 1993-04-01 |
Family
ID=22703557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8989304363T Expired - Fee Related DE68903596T2 (de) | 1988-05-06 | 1989-04-28 | Verfahren zur herstellung von 2-(difluormethoxy)-1,1,1,2-tetrafluorethan. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0341004B1 (enExample) |
| JP (1) | JPH0262839A (enExample) |
| CA (1) | CA1310983C (enExample) |
| DE (1) | DE68903596T2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5026924A (en) * | 1989-03-14 | 1991-06-25 | Anaquest, Inc. | Process for production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897502A (en) * | 1971-10-22 | 1975-07-29 | Airco Inc | Process for making fluorinated ethers |
| US4762856A (en) * | 1987-02-02 | 1988-08-09 | Boc, Inc. | Anesthetic composition and method of using the same |
-
1989
- 1989-04-25 CA CA000597661A patent/CA1310983C/en not_active Expired - Lifetime
- 1989-04-28 EP EP89304363A patent/EP0341004B1/en not_active Expired - Lifetime
- 1989-04-28 DE DE8989304363T patent/DE68903596T2/de not_active Expired - Fee Related
- 1989-05-02 JP JP1113531A patent/JPH0262839A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0341004A2 (en) | 1989-11-08 |
| JPH0552818B2 (enExample) | 1993-08-06 |
| EP0341004B1 (en) | 1992-11-25 |
| CA1310983C (en) | 1992-12-01 |
| DE68903596D1 (de) | 1993-01-07 |
| JPH0262839A (ja) | 1990-03-02 |
| EP0341004A3 (en) | 1991-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE68907783T2 (de) | Verfahren zur herstellung von fluorierten aethern. | |
| DE112013000676T5 (de) | Bis(1,1-dichlor-3,3,3-trifluorpropyl)ether und Verfahen zur Herstellung davon | |
| DE69004717T2 (de) | Verfahren zur Herstellung von 1,2,2,2-Tetrafluorethyl-Difluormethyläther. | |
| EP0036123A1 (de) | Verfahren zur Herstellung von hochreinen teilfluorierten Äthanen | |
| CH632230A5 (de) | Verfahren zur herstellung von m-phenoxybenzaldehyd. | |
| DE68903596T2 (de) | Verfahren zur herstellung von 2-(difluormethoxy)-1,1,1,2-tetrafluorethan. | |
| DE69310017T2 (de) | Verfahren zur Herstellung von funktionalisierten Perfluorpolyoxyalkylenen | |
| DE68906986T2 (de) | Verfahren zur herstellung von chf20chfcf3 und chf20chclcf3 und dabei verwendete zwischenverbindungen. | |
| EP0037003A1 (de) | 2,3-Dichlor-2-trifluormethyl-1,1,1,3,4,4,5,5,5-nonafluorpentan und Verfahren zu seiner Herstellung | |
| DE2629775A1 (de) | Verfahren zur herstellung von brom-(chlor)-fluorkohlenwasserstoffen | |
| US4340548A (en) | Process for the preparation of perhaloalkanoyl chloride | |
| DE69718171T2 (de) | Verfahren zur herstellung von diiod flourverbindungen unter verwendung von cf2i2 und olefinen | |
| DE60107121T2 (de) | Verfahren zur herstellung von fluormethylhexafluorisopropyl-ether | |
| DE3133732C2 (de) | Verfahren zur Herstellung von Difluorbromacetylfluorid oder Difluorjodacetylfluorid | |
| US4968852A (en) | Trifluoromethylbenzoyl bromide and conversion of same to bromobenzotrifluoride | |
| DE4213849A1 (de) | Verfahren zur â-Chlorierung von Arylethern | |
| DE10101150A1 (de) | Verfahren zur Herstellung trifluormethyl-substituierter Biphenylcarbonsäuren und neue trichlormethyl-und trifluormethyl-substituierte Biphenylcarbonitrile | |
| DE3509911C2 (de) | Verfahren zur Herstellung von Trifluoressigsäure aus Trichlortrifluorethan | |
| CA1169877A (en) | Conversion of 1,1,1-trichloroperhaloalkanes into perhaloalkanoyl chlorides | |
| EP0136566A2 (de) | Verfahren zur Herstellung von 3,4-Dichlorbenzotrihalogeniden | |
| DE3635750C2 (de) | Fluorhaltige Verbindung, Verfahren zu deren Herstellung, sowie deren Verwendung | |
| DE68908511T2 (de) | Verzweigte Perfluoralkylhalogenide und Verfahren zu ihrer Herstellung. | |
| DE2347109C2 (de) | Verfahren zur Herstellung von halogenhaltigen tertiären Phosphinoxiden | |
| DE2203326C3 (de) | Verfahren zur Herstellung von Trifluoracetylchlorid | |
| EP0725050B1 (de) | Verfahren zur Herstellung von kernhalogenierten Benzotrichloriden aus den entsprechenden Benzotrifluoriden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BAXTER INTERNATIONAL INC. (N.D.GES.D. STAATES DELA |
|
| 8339 | Ceased/non-payment of the annual fee |