DE68902647T2 - Antiarthritische beta-cycloalkyl-beta-oxopropionitrile. - Google Patents

Antiarthritische beta-cycloalkyl-beta-oxopropionitrile.

Info

Publication number
DE68902647T2
DE68902647T2 DE8989101278T DE68902647T DE68902647T2 DE 68902647 T2 DE68902647 T2 DE 68902647T2 DE 8989101278 T DE8989101278 T DE 8989101278T DE 68902647 T DE68902647 T DE 68902647T DE 68902647 T2 DE68902647 T2 DE 68902647T2
Authority
DE
Germany
Prior art keywords
beta
antiarthritic
cycloalkyl
oxopropionitrile
oxopropionitriles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989101278T
Other languages
German (de)
English (en)
Other versions
DE68902647D1 (en
Inventor
William T Han
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE68902647D1 publication Critical patent/DE68902647D1/de
Application granted granted Critical
Publication of DE68902647T2 publication Critical patent/DE68902647T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8989101278T 1988-01-26 1989-01-25 Antiarthritische beta-cycloalkyl-beta-oxopropionitrile. Expired - Fee Related DE68902647T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/148,540 US4888357A (en) 1988-01-26 1988-01-26 Antiarthritic β-cycloalkyl-β-oxopropionitriles

Publications (2)

Publication Number Publication Date
DE68902647D1 DE68902647D1 (en) 1992-10-08
DE68902647T2 true DE68902647T2 (de) 1993-02-04

Family

ID=22526203

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989101278T Expired - Fee Related DE68902647T2 (de) 1988-01-26 1989-01-25 Antiarthritische beta-cycloalkyl-beta-oxopropionitrile.

Country Status (7)

Country Link
US (1) US4888357A (US06380249-20020430-C00169.png)
EP (1) EP0326107B1 (US06380249-20020430-C00169.png)
JP (1) JPH021451A (US06380249-20020430-C00169.png)
AT (1) ATE80157T1 (US06380249-20020430-C00169.png)
CA (1) CA1314562C (US06380249-20020430-C00169.png)
DE (1) DE68902647T2 (US06380249-20020430-C00169.png)
GR (1) GR3005584T3 (US06380249-20020430-C00169.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL92508A0 (en) * 1988-12-08 1990-08-31 Ciba Geigy Ag Novel alpha-cyano-beta-oxopropionamides
IL99811A (en) * 1990-10-30 1996-03-31 Roussel Uclaf 3-Cycloalkyl-propanamides, tautomeric forms of these, their salts, method of preparation, use as drugs and preparations containing them
GB9023535D0 (en) * 1990-10-30 1990-12-12 Roussel Lab Ltd Chemical compounds
IL102790A (en) * 1991-09-17 1996-01-31 Roussel Uclaf History of 3-cycloalkyl-prop-2-anamide
GB9300083D0 (en) 1993-01-05 1993-03-03 Roussel Lab Ltd Chemical compounds
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
JP2594965Y2 (ja) * 1993-12-27 1999-05-24 株式会社柿崎製作所 道路付帯設備用支柱のキャップ
GB9405229D0 (en) * 1994-03-17 1994-04-27 Rhone Poulenc Agriculture Compositions of matter
JP5544892B2 (ja) * 2010-01-19 2014-07-09 日亜化学工業株式会社 ２−シアノ−１，３−ジケトネート塩の製造法及びイオン液体

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016295A (en) * 1958-06-23 1962-01-09 Du Pont Method for altering the growth characteristics of plants
DE1237105B (de) * 1965-06-26 1967-03-23 Riedel De Haeen Ag Verfahren zur Herstellung von Thiocarbonsaeureamiden
US3406183A (en) * 1966-11-01 1968-10-15 American Home Prod 3-n-arylamino-3-mercapto-2-cyanoacrylamides
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DE2555789A1 (de) * 1975-12-11 1977-07-07 Hoechst Ag Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4170656A (en) * 1977-05-31 1979-10-09 American Cyanamid Company Compositions containing cis-2-benzoyl-3-hydroxy-crotononitrile used to treat inflammation and joint deterioration
US4189436A (en) * 1977-11-22 1980-02-19 American Cyanamid Company β-oxo-3-thiophene propionitrile and β-amino-2-(3)-thiophene acrylonitriles
US4173650A (en) * 1978-11-03 1979-11-06 American Cyanamid Company Cis-2-benzoyl-3-hydroxy-2-alkenonitriles as anti-inflammatory agents
US4197310A (en) * 1979-04-30 1980-04-08 American Cyanamid Company Thiophenepropionitriles
US4256759A (en) * 1979-06-11 1981-03-17 Ciba-Geigy Corporation Alphacarbamoyl-pyrrolpropionitriles
US4254047A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl-2-cyano-2-thioalkenoic acid esters
US4254048A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl alkylidene acetoacetonitriles
US4254049A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl-2-cyano-2-alkenoic acid esters
US4435407A (en) * 1982-01-07 1984-03-06 Ciba-Geigy Corporation Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
DE3209472C2 (de) * 1982-03-16 1984-05-17 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von 3-Oxonitrilen sowie neue 3-Oxonitrile
DE3217446A1 (de) * 1982-05-08 1983-11-24 A. Nattermann & Cie GmbH, 5000 Köln Substituierte thiocarbamoyl-thenoylacetonitrile, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4644010A (en) * 1982-09-28 1987-02-17 Ciba-Geigy Corporation Certain β-oxo-α-carbamoylpyrrolepropionitriles
IL72093A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives

Also Published As

Publication number Publication date
EP0326107A1 (en) 1989-08-02
JPH021451A (ja) 1990-01-05
GR3005584T3 (US06380249-20020430-C00169.png) 1993-06-07
JPH0567616B2 (US06380249-20020430-C00169.png) 1993-09-27
ATE80157T1 (de) 1992-09-15
EP0326107B1 (en) 1992-09-02
DE68902647D1 (en) 1992-10-08
US4888357A (en) 1989-12-19
CA1314562C (en) 1993-03-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee