DE644646C - Process for the preparation of heavy metal compounds from salts of the acridinium compounds - Google Patents

Description

GERMAN EMPIRE

ISSUED ON May 12, 1937

REICH LATE OFFICE

PATENT LETTERING

M 644646 CLASS 12 p GROUP l'so

I. G. Farbenindustrie Akt.-Ges. in Frankfurt, Main *)

Process for the production of heavy metal compounds from salts of the acridinium compounds

Patented in the German Empire on May 27, 1932

The subject of the patent 644 076 is a process for the preparation of salts of Acridinium bases, in the case of salts, the ammonium bases are converted into bicarbonates and these can then be dissolved in any acid.

It has now been found that valuable heavy metal compounds of acridinium bases can be obtained obtained by adding heavy metal salts to the salts obtainable by the process of patent 644076. With help this process is the combined pharmaceutical application of quaternary ammonium salts with heavy metal salts, for example with silver salts, possible. While known the chlorides and sulfates of the quaternary ammonium bases cannot be used at the same time as silver salts because of the formation of insoluble silver salts, can be removed with the help of bicarbonates easily represent complex silver compounds of ammonium salts. In this case it solves the bicarbonates are placed in an organic acid, such as lactic acid, and set when finished Silver lactate is added to the carbon dioxide evaporation, as a result of which completely durable solutions of the silver ammonium salts are obtained.

The table below shows the results of experiments on the solubilities some of the acridinium salts obtainable through bicarbonates and their heavy metal compounds evident; the limit of solubility was not yet reached in these experiments:

■ 1: 5 to τ: ζ

3, δ-diamino-io-methylacridinium acetate 3, δ-diamino-io-methylacridimum glycolate 3, o-diamino-io-methylacridmium aminoacetate 3, ö-diaminö-io-methylacridinium citrate quinate of 3,6-diamino-io-methylacridmium base 3, o-diamino-io-methylacridinium-α-oxyphenyl acetate 3, ö-diamino-io-methylacridmium lactate j

3, o-diamino-io-methylacridinium lactate + copper acetate } 3, o-diamino-io-methylacridinium lactate + lead acetate [

3, o-diamino-io-methylacridinium acetate -j- copper acetate j F (J) / the patent seeker have been given as the inventor:

Dr. Max Bockmühl and Dr. Leonliard Stein in Frankfurt, Main-IIöclist,

at least 1:10

According to the information in Austrian patent 77320, the acridinium salts required for the production of heavy metal compounds of the acridine series are to be produced either by double reaction of acridinium salts with organic salts or from the free aeridinium bases with acids. The first-mentioned implementation is not quantitative. Furthermore, the inorganic salts inevitably present in the reaction solution interfere with the subsequent reaction of the acridinium salt with the heavy metal compound. The second method mentioned above also has considerable disadvantages, which are the difficult preparation of the free acridinium bases. Only the representation of the acridinium salts to be converted via the bicarbonates of the bases makes it possible to carry out the subsequent conversion with heavy metal salts without difficulty.

example

2.2 g of the bicarbonate shown in Example 1 of patent -644076 are mixed with 1'a > 9 g of 90% lactic acid; the .öanze is made up to 200 ecm after adding 1.5 g of silver • Kfactat. The solution is durable. If necessary, buffer salts can be added or the solution can be adjusted to be neutral.

Claims (1)

Claim: Process for the preparation of heavy metal compounds from salts of the Acridinium compounds, characterized in that the bicarbonates of the acridinium bases are dissolved in such organic acids which with the quaternary Ammonium bases form readily soluble salts in water, and the salts obtained are reacted with heavy metal salts.