DE624340C - Process for the preparation of durable, dry hormone preparations in solid form - Google Patents

Process for the preparation of durable, dry hormone preparations in solid form

Info

Publication number
DE624340C
DE624340C DEI46795D DEI0046795D DE624340C DE 624340 C DE624340 C DE 624340C DE I46795 D DEI46795 D DE I46795D DE I0046795 D DEI0046795 D DE I0046795D DE 624340 C DE624340 C DE 624340C
Authority
DE
Germany
Prior art keywords
durable
dry
solid form
preparation
hormones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI46795D
Other languages
German (de)
Inventor
Dr Max Bockmuehl
Dr Fritz Lindner
Dr Otto Schaumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI46795D priority Critical patent/DE624340C/en
Application granted granted Critical
Publication of DE624340C publication Critical patent/DE624340C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

Verfahren zur Darstellung haltbarer. Hormontrockenpräparate in fester Form Man hat bereits mehrfach die parenterale Anwendung von Hormonen in Trockensubstanz versucht. So hat man beispielsweise Präparate aus den Hypophysenhinterlappen bei Diabetes insipidus in Form von Schnupfpulver verwendet. Da die betreffenden Hormone wegen ihrer außerordentlichen Wirksamkeit nur in kleinen Mengen verabfolgt werden können und daher nur in hohen Verdünnungen anwendbar sind, ist man darauf angewiesen, die Hormone mit indifferenten Pulvern zu verreiben. Dieses Verfahren setzt aber die Haltbarkeit der Hormone in den betreffenden festen Verdünnungsmitteln voraus. Wie Versuche ergeben haben, sind solche Verreibungen vieler Hormone mit den üblichen Streckungsmitteln, wie Milchzucker, Harnstoff und anderen, nicht haltbar. Man hat daher den Ausweg gewählt, die gesamten, das oder die Hormone enthaltenden Drüsen in getrocknetem und pulverisiertem Zustande anzuwenden. . So wird beispielsweise seit längerer Zeit der gesamte Hinterlappen der Hirndrüse in getrocknetem Zustande verwendet. Diese Maßnahme hat aber den Nachteil, daß man gezwungen ist, nicht das jeweils gewünschte Hormon, sondern die Gesamtheit der in dem Drüsenanteil vorhandenen Hormone und Begleitsubstanzen zur Anwendung zu bringen.Method of rendering more durable. Hormone dry preparations in solid Form One has already several times the parenteral application of hormones in dry substance tries. For example, you have preparations from the posterior pituitary gland with you Diabetes insipidus used in the form of snuff. Because the hormones in question can only be administered in small quantities because of their extraordinary effectiveness can and can therefore only be used in high dilutions, one is dependent on to rub the hormones with indifferent powders. However, this procedure continues the shelf life of the hormones in the solid diluents concerned. Tests have shown that such triturations of many hormones are common Extenders such as lactose, urea and others are not durable. One has therefore the solution chosen was the entire gland containing the hormone or hormones to be used in the dried and powdered state. . For example for a long time the entire posterior lobe of the brain gland in a dry state used. But this measure has the disadvantage that you are forced to do this the desired hormone in each case, but rather the entirety of those present in the part of the gland Bring hormones and accompanying substances to use.

Es wurde nun gefunden, daß man haltbare Verdünnungen der Hormone in .fester Form dadurch gewinnen kann, daß nach bekannten Methoden gewonnene Hormone an hochmolekulare eiweißartige Stoffe, deren hochmolekulare Abbauprodukte und andere bindet. Das Verfahren wird beispielsweise in der Weise ausgeführt, daß man die Hormone mit den sog. trägerartigen Stoffen in einem geeigneten Lösungsmittel für beide Komponenten, wie z. B. Eisessig, wäßrige Säuren oder Alkalien löst und die erhaltenen Lösungen mit einem Fällungsmittel, in welchem sowohl die Hormone als auch die Trägersubstanzen unlöslich sind, versetzt. Die abgeschiedenen und getrockneten Hormonpräparate lassen sich in beliebiger Weise mit Streckungsmitteln, wie Harnstoff, Michzucker und anderen, vermischen. Beispiel 2o mg des pulverisierten, darmtonisierend und diuresehemmend wirkenden Hypophysenhinterlappenhormons mit r oo Einheiten im Milligramm werden in 2 ccm Eisessig gelöst. Dazu gibt man die Lösung von 2 g protalbinsaurem Natrium in io ccm Eisessig und fällt mit einem Gemisch von_ ioo ccm Aceton zoo ccm Äther. Die Fällung wird abgeschleudert, mit Äther gewaschen und getrocknet. Das Trockenpulver wird mit der fünffachen Menge Milchzucker verrieben.It has now been found that stable dilutions of the hormones in Can win solid form by the fact that hormones obtained by known methods of high molecular weight protein-like substances, their high molecular weight breakdown products and others binds. The method is carried out, for example, in such a way that the hormones with the so-called carrier-like substances in a suitable solvent for both components, such as B. glacial acetic acid, aqueous acids or alkalis dissolves and the resulting solutions with a precipitant in which both the hormones and the carrier substances are insoluble. Leave the deposited and dried hormone preparations in any way with diluents such as urea, milk sugar and others, mix. Example 20 mg of the powdered, intestinal and anti-diuretic acting posterior pituitary hormone with r oo units in milligrams dissolved in 2 cc of glacial acetic acid. The solution of 2 g protalbinic acid is added to this sodium in 10 cc of glacial acetic acid and precipitates with a mixture of 100 cc of acetone and zoo cc of ether. The precipitate is spun off, washed with ether and dried. The dry powder is rubbed with five times the amount of milk sugar.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung haltbarer Hormontrockenpräparate in fester Form, dadurch gekennzeichnet, daß man nach bekannten Methoden gewonnene Hormone oder hormonhaltige Stoffe zusammen mit hochmolekularen eiweißartigen Stoffen in einem Lösungsmittel löst, aus der erhaltenen Lösung beide Stoffe mit einem geeigneten Fällungsmittel zur Abscheidung bringt und gegebenenfalls die erhaltenen Präparate mit indifferenten Stoffen verreibt. PATENT CLAIM: A method for the preparation of durable hormone dry preparations in solid form, characterized in that hormones or hormone-containing substances obtained by known methods are dissolved together with high molecular weight protein-like substances in a solvent, both substances are separated from the resulting solution with a suitable precipitant and, if necessary, the The preparations obtained are triturated with indifferent substances.
DEI46795D 1933-03-19 1933-03-19 Process for the preparation of durable, dry hormone preparations in solid form Expired DE624340C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI46795D DE624340C (en) 1933-03-19 1933-03-19 Process for the preparation of durable, dry hormone preparations in solid form

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI46795D DE624340C (en) 1933-03-19 1933-03-19 Process for the preparation of durable, dry hormone preparations in solid form

Publications (1)

Publication Number Publication Date
DE624340C true DE624340C (en) 1936-01-17

Family

ID=7191843

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI46795D Expired DE624340C (en) 1933-03-19 1933-03-19 Process for the preparation of durable, dry hormone preparations in solid form

Country Status (1)

Country Link
DE (1) DE624340C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE920148C (en) * 1951-03-31 1954-11-15 Nyegaard & Co As Process for the production of adrenocorticotrophin preparations with extended duration of action
DE1019437B (en) * 1952-08-08 1957-11-14 Agronomique Inst Nat Rech Process for the production of stable, vitamin-containing products

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE920148C (en) * 1951-03-31 1954-11-15 Nyegaard & Co As Process for the production of adrenocorticotrophin preparations with extended duration of action
DE1019437B (en) * 1952-08-08 1957-11-14 Agronomique Inst Nat Rech Process for the production of stable, vitamin-containing products

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