DE614870C - Process for the preparation of neutral injection solutions of complex salts from aromatic polyoxy compounds which contain at least two hydroxyl groups in the ortho position and also acidic, salt-forming groups, and metals or metalloids such as arsenic - Google Patents
Process for the preparation of neutral injection solutions of complex salts from aromatic polyoxy compounds which contain at least two hydroxyl groups in the ortho position and also acidic, salt-forming groups, and metals or metalloids such as arsenicInfo
- Publication number
- DE614870C DE614870C DEI38002D DEI0038002D DE614870C DE 614870 C DE614870 C DE 614870C DE I38002 D DEI38002 D DE I38002D DE I0038002 D DEI0038002 D DE I0038002D DE 614870 C DE614870 C DE 614870C
- Authority
- DE
- Germany
- Prior art keywords
- contain
- metals
- metalloids
- arsenic
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung neutraler Injektionslösungen der Komplexsalze aus aromatischen Polyoxyverbindungen, welche mindestens zwei Hydroxylgruppen in Orthostellung und außerdem saure, salzbildende Gruppen enthalten, und Metallen bzw. Metalloiden, wie Arsen Von den Komplexsalzen aus aromatischen Polyoxyverbindungen, die mindestens zwei Hydroxylgruppen in Orthostellung und außerdem saure, salzbildende Gruppen enthalten, und Metallen bzw. Metalloiden, wie Arsen, lassen sich haltbare Injektionslösungen herstellen. Man ist jedoch bei der Einstellung solcher Lösungen auf neutrale Reaktion an gewisse Grenzen gebunden, da, sobald auch nur schwach alkalische Reaktion eintritt, Verfärbungen durch oxydative Veränderungen des aromatischen Komplexbildners auftreten können. Das kann z. B. schon leicht eintreten, wenn man Injektionslösungen auf das für Injektionszwecke geeignete PH-Intervall von etwa 6,5 bis 7,5 eingestellt und die Lösungen sterilisiert.Process for the preparation of neutral injection solutions of the complex salts from aromatic polyoxy compounds which contain at least two hydroxyl groups in Ortho position and also contain acidic, salt-forming groups, and metals or Metalloids, such as arsenic From the complex salts of aromatic polyoxy compounds, the at least two hydroxyl groups in the ortho position and also acidic, salt-forming ones Groups contain, and metals or metalloids, such as arsenic, can be durable Prepare injection solutions. However, one is in the process of setting such solutions bound to a neutral reaction to certain limits, as soon as only weakly alkaline Reaction occurs, discoloration due to oxidative changes in the aromatic complexing agent may occur. This can be B. occur easily if you have injection solutions adjusted to the pH interval suitable for injections of about 6.5 to 7.5 and the solutions sterilized.
Es wurde nun gefunden, daß man solche Verfärbungen verhindern kann, wenn man schwefligsaure Salze zusetzt.It has now been found that such discoloration can be prevented when adding sulphurous acid salts.
Beispiel = Fügt man zu einer 6,3°/oigen Lösung von antimonylbrenzeatechindisulfonsaurem Natrium im Verhältnis z; xooo Natriummetabisulfit hinzu und stellt dann durch Zusatz basischer Stoffe die Lösung auf eine Wasserstoffionenkonzentration PH gleich oder etwas größer als 7 ein, so erhält man nach dem Sterilisieren in der Ampulle eine farblose Lösung.Example = one adds to a 6.3% solution of antimonylbrenzeatechindisulfonsaurem Sodium in the ratio z; xooo sodium metabisulphite is added and then represents by addition basic substances the solution to a hydrogen ion concentration equal to or PH slightly larger than 7, you will get a after sterilization in the ampoule colorless solution.
In ähnlicher Weise kann man z. B. eine farblose Injektionslösung aus antimonylpyrogalloldisulfonsaurem Natrium herstellen.In a similar way you can z. B. a colorless injection solution Prepare sodium antimonylpyrogalloldisulfonic acid.
Beispiel 2 6, 15 g manganbrenzcatechindisulfonsaures Natrium werden unter Zusatz von x g Natriummetabisulfit in z 1 Wasser gelöst, die Lösung durch Zusatz verdünnter Natronlauge auf einen PH von etwa 7,o eingestellt, in Ampullen gefüllt und sterilisiert. Man erhält eine nur schwach gefärbte Lösung.Example 2 6, 15 g of sodium manganese catechol disulfonic acid with the addition of x g of sodium metabisulphite dissolved in z 1 water, the solution through Addition of dilute sodium hydroxide solution adjusted to a pH of about 7, in ampoules filled and sterilized. An only slightly colored solution is obtained.
Beispiel 3 5 g antimonprotocatechusaures Natrium werden unter Zugeben von 0,2 g Natriumbisulfit in Wasser gelöst, die Lösung mit verdünntem Ammoniak auf einen pH von etwa 7,o eingestellt, auf =ooccm aufgefüllt und in Ampullen sterilisiert. Man erhält eine hellgefärbte Lösung. Beispiel ¢ ao g wismutbrenzcatechindisulfonsaures Natrium werden unter Zugabe von o,a g Natriumbisulfit in Wasser gelöst, durch Zusatz verdünnten Alkalis auf einen pH von etwa 7,0 eingestellt, auf ioo ccm aufgefüllt, in Ampullen gefüllt und sterilisiert. Man erhält eine hellgefärbte Injektionslösung.Example 3 5 g of sodium antimony protocatechic acid are added with addition of 0.2 g of sodium bisulfite dissolved in water, the solution with dilute ammonia adjusted to a pH of about 7.0, made up to = ooccm and sterilized in ampoules. A light colored solution is obtained. Example ¢ ao g bismuth catechol disulfonic acid Sodium is dissolved in water with the addition of o, a g of sodium bisulfite, by adding diluted Alkalis adjusted to a pH of about 7.0, to ioo ccm filled, filled into ampoules and sterilized. A light-colored one is obtained Solution for injection.
In analoger Weise läßt sich das Verfahren auf die Komplexverbindungen anderer Metalle, soweit sie nicht mit dem Sulfit unerwünschte Reaktionen geben, z. B. schwerlösliche Verbindungen eingehen, mit aromatischen Polyoxyverbindungen der gekennzeichneten Art ausdehnen.The process can be applied to the complex compounds in an analogous manner other metals, as long as they do not cause undesirable reactions with the sulphite, z. B. enter into sparingly soluble compounds with aromatic polyoxy compounds stretch of the designated type.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI38002D DE614870C (en) | 1929-05-11 | 1929-05-11 | Process for the preparation of neutral injection solutions of complex salts from aromatic polyoxy compounds which contain at least two hydroxyl groups in the ortho position and also acidic, salt-forming groups, and metals or metalloids such as arsenic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI38002D DE614870C (en) | 1929-05-11 | 1929-05-11 | Process for the preparation of neutral injection solutions of complex salts from aromatic polyoxy compounds which contain at least two hydroxyl groups in the ortho position and also acidic, salt-forming groups, and metals or metalloids such as arsenic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE614870C true DE614870C (en) | 1935-06-20 |
Family
ID=7189669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEI38002D Expired DE614870C (en) | 1929-05-11 | 1929-05-11 | Process for the preparation of neutral injection solutions of complex salts from aromatic polyoxy compounds which contain at least two hydroxyl groups in the ortho position and also acidic, salt-forming groups, and metals or metalloids such as arsenic |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE614870C (en) |
-
1929
- 1929-05-11 DE DEI38002D patent/DE614870C/en not_active Expired
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