DE60333295D1 - Verfahren zum nachweis abnormal methylierter nukleinsäure in heterogenen biologischen proben - Google Patents
Verfahren zum nachweis abnormal methylierter nukleinsäure in heterogenen biologischen probenInfo
- Publication number
- DE60333295D1 DE60333295D1 DE60333295T DE60333295T DE60333295D1 DE 60333295 D1 DE60333295 D1 DE 60333295D1 DE 60333295 T DE60333295 T DE 60333295T DE 60333295 T DE60333295 T DE 60333295T DE 60333295 D1 DE60333295 D1 DE 60333295D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- biological samples
- heterogenic
- methylated nucleic
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/123,071 US6818404B2 (en) | 1997-10-23 | 2002-04-11 | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
| PCT/US2003/011023 WO2003087390A2 (en) | 2002-04-11 | 2003-04-11 | Methods for detecting abnormally methylated nucleic acid in heterogeneous biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60333295D1 true DE60333295D1 (de) | 2010-08-19 |
Family
ID=29248336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60333295T Expired - Lifetime DE60333295D1 (de) | 2002-04-11 | 2003-04-11 | Verfahren zum nachweis abnormal methylierter nukleinsäure in heterogenen biologischen proben |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6818404B2 (de) |
| EP (2) | EP1527199B1 (de) |
| AT (1) | ATE473296T1 (de) |
| AU (1) | AU2003226052A1 (de) |
| CA (2) | CA2482192C (de) |
| DE (1) | DE60333295D1 (de) |
| ES (1) | ES2347990T3 (de) |
| PT (1) | PT1527199E (de) |
| WO (1) | WO2003087390A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2269129T3 (es) * | 1999-04-09 | 2007-04-01 | Exact Sciences Corporation | Procedimientos para detectar acidos nucleicos reveladores de cancer. |
| US6586177B1 (en) * | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| WO2001042781A2 (en) * | 1999-12-07 | 2001-06-14 | Exact Sciences Corporation | Supracolonic aerodigestive neoplasm detection |
| US6919174B1 (en) * | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
| WO2002018649A1 (en) * | 2000-08-25 | 2002-03-07 | Lovelace Respiratory Research Institute | Nested methylation-specific polymerase chain reaction cancer detection method |
| US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
| US6960436B2 (en) * | 2002-02-06 | 2005-11-01 | Epigenomics Ag | Quantitative methylation detection in DNA samples |
| AU2003213107A1 (en) | 2002-02-15 | 2003-09-09 | Exact Sciences Corporation | Methods for analysis of molecular events |
| US20040259101A1 (en) * | 2003-06-20 | 2004-12-23 | Shuber Anthony P. | Methods for disease screening |
| WO2005017183A2 (en) * | 2003-06-24 | 2005-02-24 | Johns Hopkins University | Methylated gene biomarkers for detecting cancer |
| US20050059035A1 (en) * | 2003-09-09 | 2005-03-17 | Quest Diagnostics Incorporated | Methods and compositions for the amplification of mutations in the diagnosis of cystic fibrosis |
| US7423164B2 (en) | 2003-12-31 | 2008-09-09 | Ut-Battelle, Llc | Synthesis of ionic liquids |
| WO2005111244A2 (en) * | 2004-05-10 | 2005-11-24 | Exact Sciences Corporation | Methods for detecting a mutant nucleic acid |
| WO2006026654A2 (en) | 2004-08-27 | 2006-03-09 | Exact Sciences Corporation | Method for detecting a recombinant event |
| WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
| WO2006094149A2 (en) * | 2005-03-01 | 2006-09-08 | Exact Sciences Corporation | Methods and compositions for detecting adenoma |
| US7449297B2 (en) | 2005-04-14 | 2008-11-11 | Euclid Diagnostics Llc | Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays |
| AU2006236363B2 (en) * | 2005-04-15 | 2012-11-01 | Epigenomics Ag | A method for providing DNA fragments derived from a remote sample |
| US9777314B2 (en) | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
| US20080003609A1 (en) * | 2006-05-10 | 2008-01-03 | The Cleveland Clinic Foundation | Method of detecting bladder urothelial carcinoma |
| US20120196827A1 (en) * | 2006-06-12 | 2012-08-02 | Oncomethylome Sciences S.A. | Methylation markers for early detection and prognosis of colon cancers |
| US20080213870A1 (en) * | 2007-03-01 | 2008-09-04 | Sean Wuxiong Cao | Methods for obtaining modified DNA from a biological specimen |
| WO2009100161A2 (en) * | 2008-02-04 | 2009-08-13 | Fred Hutchinson Cancer Research Center | Epigenetic silencing of mir-342 in colorectal cancer |
| US8673555B2 (en) | 2008-02-15 | 2014-03-18 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| ES2346503B1 (es) | 2008-11-03 | 2011-08-03 | Fina Biotech, S.L.U. | Metodo de diagnostico de cancer colorectal. |
| US8399138B2 (en) * | 2009-10-14 | 2013-03-19 | GM Global Technology Operations LLC | Liquid rechargeable lithium ion battery |
| WO2012032510A1 (en) * | 2010-09-07 | 2012-03-15 | Yeda Research And Development Co. Ltd. | Primers for amplifying dna and methods of selecting same |
| WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
| WO2015095689A1 (en) | 2013-12-19 | 2015-06-25 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
| CN109642228B (zh) | 2016-07-19 | 2022-09-13 | 精密科学发展有限责任公司 | 甲基化对照dna |
| ES2963227T3 (es) | 2016-07-19 | 2024-03-26 | Exact Sciences Corp | Moléculas de control de ácido nucleico de organismos no humanos |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| IE66572B1 (en) | 1989-02-13 | 1996-01-24 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
| ATE131878T1 (de) | 1989-09-01 | 1996-01-15 | Life Technologies Inc | Verfahren zur überprüfung der kontamination von oligonukleotidabhängigen nukleinsäure- amplifikationsreaktionen |
| AU7653691A (en) | 1990-04-05 | 1991-10-30 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Modified rna template-specific polymerase chain reaction |
| HU218095B (hu) | 1990-05-01 | 2000-05-28 | Amgen Inc. | Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban |
| DE69231734T2 (de) | 1991-01-16 | 2001-09-20 | Univ Johns Hopkins | Geerbte und somatische mutationen des apc-gens bei menschlichem colorectal-krebs |
| US5633134A (en) | 1992-10-06 | 1997-05-27 | Ig Laboratories, Inc. | Method for simultaneously detecting multiple mutations in a DNA sample |
| US5882856A (en) | 1995-06-07 | 1999-03-16 | Genzyme Corporation | Universal primer sequence for multiplex DNA amplification |
| US5670325A (en) | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| US5741650A (en) | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6143529A (en) | 1996-08-14 | 2000-11-07 | Exact Laboratories, Inc. | Methods for improving sensitivity and specificity of screening assays |
| US6146828A (en) | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
| US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
| US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6020137A (en) | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
| US5830665A (en) | 1997-03-03 | 1998-11-03 | Exact Laboratories, Inc. | Contiguous genomic sequence scanning |
| US5888778A (en) | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
| US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
| US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| EP1025265A1 (de) | 1997-10-23 | 2000-08-09 | Exact Laboratories, Inc. | Methode zur detektion von kontaminationen in der molekularen diagnostik mit hilfe der pcr |
| AUPP312998A0 (en) * | 1998-04-23 | 1998-05-14 | Commonwealth Scientific And Industrial Research Organisation | Diagnostic assay |
| US7700324B1 (en) * | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| AU1526400A (en) | 1998-11-23 | 2000-06-19 | Exact Laboratories, Inc. | Method for detecting target sequences in small proportions in heterogeneous samples |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
| WO2000070096A2 (en) | 1999-01-10 | 2000-11-23 | Exact Laboratories, Inc. | Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus |
| WO2000050640A1 (en) | 1999-02-25 | 2000-08-31 | Exact Laboratories, Inc. | Methods for preserving dna integrity |
| US20020004206A1 (en) | 1999-04-09 | 2002-01-10 | Berger Barry M. | Methods of screening for disease |
| ES2269129T3 (es) | 1999-04-09 | 2007-04-01 | Exact Sciences Corporation | Procedimientos para detectar acidos nucleicos reveladores de cancer. |
| CA2372145A1 (en) | 1999-05-03 | 2000-11-09 | Exact Sciences Corporation | Stool specimen collector |
| US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| WO2001042503A2 (en) | 1999-12-07 | 2001-06-14 | Exact Sciences Corporation | Apparatus and methods for drug screening based on nucleic acid analysis |
| WO2001042781A2 (en) | 1999-12-07 | 2001-06-14 | Exact Sciences Corporation | Supracolonic aerodigestive neoplasm detection |
| WO2001064950A2 (en) | 2000-02-28 | 2001-09-07 | Exact Sciences Corporation | Device and method for preparing a sample for analysis |
| WO2001068911A2 (en) * | 2000-03-15 | 2001-09-20 | Epigenomics Ag | Diagnosis of diseases associated with the cell cycle |
| US20040033490A1 (en) * | 2000-03-31 | 2004-02-19 | Laird Peter W. | Epigenetic sequences for esophageal adenocarcinoma |
| EP2014776A3 (de) | 2000-04-06 | 2009-04-01 | Epigenomics AG | Diagnose von mit DNA-Transkriptionen assoziierten Erkrankungen |
| EP1294947A2 (de) | 2000-06-30 | 2003-03-26 | Epigenomics AG | Verfahren und nukleinsäuren für die pharmakogenomische methyllationsanalyse |
| WO2002018649A1 (en) * | 2000-08-25 | 2002-03-07 | Lovelace Respiratory Research Institute | Nested methylation-specific polymerase chain reaction cancer detection method |
| US6911308B2 (en) | 2001-01-05 | 2005-06-28 | Exact Sciences Corporation | Methods for detecting, grading or monitoring an H. pylori infection |
| US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
| JP2004521630A (ja) | 2001-03-15 | 2004-07-22 | エグザクト サイエンシーズ コーポレイション | 変更検出のための方法 |
| US20030049659A1 (en) | 2001-05-29 | 2003-03-13 | Lapidus Stanley N. | Devices and methods for isolating samples into subsamples for analysis |
| ATE428925T1 (de) | 2001-11-20 | 2009-05-15 | Exact Sciences Corp | Automatische probenvorbereitungsverfahren und - vorrichtungen |
-
2002
- 2002-04-11 US US10/123,071 patent/US6818404B2/en not_active Expired - Fee Related
-
2003
- 2003-04-11 EP EP03746704A patent/EP1527199B1/de not_active Expired - Lifetime
- 2003-04-11 PT PT03746704T patent/PT1527199E/pt unknown
- 2003-04-11 AU AU2003226052A patent/AU2003226052A1/en not_active Abandoned
- 2003-04-11 CA CA2482192A patent/CA2482192C/en not_active Expired - Fee Related
- 2003-04-11 EP EP10168634.3A patent/EP2241638B1/de not_active Expired - Lifetime
- 2003-04-11 DE DE60333295T patent/DE60333295D1/de not_active Expired - Lifetime
- 2003-04-11 WO PCT/US2003/011023 patent/WO2003087390A2/en not_active Application Discontinuation
- 2003-04-11 CA CA2726356A patent/CA2726356A1/en not_active Abandoned
- 2003-04-11 ES ES03746704T patent/ES2347990T3/es not_active Expired - Lifetime
- 2003-04-11 AT AT03746704T patent/ATE473296T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1527199A2 (de) | 2005-05-04 |
| AU2003226052A1 (en) | 2003-10-27 |
| CA2482192A1 (en) | 2003-10-23 |
| US6818404B2 (en) | 2004-11-16 |
| ES2347990T3 (es) | 2010-11-26 |
| EP2241638B1 (de) | 2013-11-27 |
| CA2482192C (en) | 2011-03-15 |
| EP2241638A1 (de) | 2010-10-20 |
| EP1527199A4 (de) | 2006-02-15 |
| CA2726356A1 (en) | 2003-10-23 |
| PT1527199E (pt) | 2010-09-27 |
| WO2003087390A2 (en) | 2003-10-23 |
| WO2003087390A9 (en) | 2004-05-27 |
| ATE473296T1 (de) | 2010-07-15 |
| EP1527199B1 (de) | 2010-07-07 |
| WO2003087390A3 (en) | 2005-03-10 |
| AU2003226052A8 (en) | 2003-10-27 |
| US20030087258A1 (en) | 2003-05-08 |
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