DE60330997D1 - Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungen - Google Patents
Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungenInfo
- Publication number
- DE60330997D1 DE60330997D1 DE60330997T DE60330997T DE60330997D1 DE 60330997 D1 DE60330997 D1 DE 60330997D1 DE 60330997 T DE60330997 T DE 60330997T DE 60330997 T DE60330997 T DE 60330997T DE 60330997 D1 DE60330997 D1 DE 60330997D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical compositions
- cosmetic
- ppar
- applications
- gamma receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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PCT/EP2003/014861 WO2004046091A2 (en) | 2002-11-19 | 2003-11-18 | Biaromatic compounds which activate ppar-gama type receptors, and use thereof in cosmetic or pharmaceutical compositions |
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US7122580B2 (en) * | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
EP1575911B1 (de) * | 2002-11-19 | 2010-01-13 | Galderma Research & Development | Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungen |
WO2005014533A2 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
WO2005014532A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
GB0319069D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Therapeutically useful compounds |
GB0321538D0 (en) * | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
MX2007001942A (es) * | 2004-08-17 | 2007-05-09 | Galderma Res & Dev | Nuevos compuestos biaromaticos activadores de los receptores del tipo receptor activado del proliferador de peroxisoma (ppar) y su uso en composiciones cosmeticas o farmaceuticas. |
US7671052B2 (en) * | 2004-10-05 | 2010-03-02 | Adolor Corporation | Phenyl derivatives and methods of use |
WO2006044961A1 (en) * | 2004-10-20 | 2006-04-27 | Smithkline Beecham Corporation | Ppar-gamma modulatores |
FR2878247B1 (fr) | 2004-11-19 | 2008-10-03 | Galderma Res & Dev | Nouveaux composes modulateurs des recepteurs de type ppary et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
FR2879601B1 (fr) * | 2004-12-22 | 2007-01-19 | Galderma Res & Dev | Nouveaux composes derives d'acide phenyl-boronique et leur procede de preparation |
ZA200805192B (en) | 2005-12-29 | 2009-11-25 | Lexicon Pharmaceuticals Inc | Multicyclic amino acid derivatives and methods of their use |
AU2007309569A1 (en) | 2006-10-20 | 2008-05-02 | Merck Sharp & Dohme Corp. | Substituted imidazoles as bombesin receptor subtype-3 modulators |
JP2010506916A (ja) | 2006-10-20 | 2010-03-04 | メルク エンド カムパニー インコーポレーテッド | ボンベシンレセプターサブタイプ3モジュレーターとしての置換イミダゾール |
BRPI0717976A2 (pt) | 2006-10-20 | 2013-11-12 | Merck & Co Inc | Composto ou um sal farmaceuticamente aceitável do mesmo, composição, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
AU2007332867B2 (en) | 2006-12-11 | 2012-02-16 | Merck Sharp & Dohme Corp. | Substituted diazepine sulfonamides as bombesin receptor subtype-3 modulators |
MX2013006805A (es) * | 2010-12-15 | 2013-07-29 | Theravance Inc | Inhibidores de la neprilisina. |
JP5959065B2 (ja) * | 2011-02-17 | 2016-08-02 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
HUE032802T2 (hu) * | 2012-06-08 | 2017-10-30 | Theravance Biopharma R&D Ip Llc | Neprilizininhibitorok |
WO2014124523A1 (en) * | 2013-02-15 | 2014-08-21 | Mcmaster University | A method of treating obesity |
US11278549B2 (en) | 2013-02-15 | 2022-03-22 | Mcmaster University | Method of treating obesity |
CN115703745A (zh) * | 2021-08-10 | 2023-02-17 | 中国船舶重工集团公司第七一八研究所 | 一种恩杂鲁胺的制备方法 |
WO2023126169A1 (en) * | 2021-12-31 | 2023-07-06 | Unilever Ip Holdings B.V. | Use of carboxymethyl cysteine compound |
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EE200100317A (et) * | 1998-12-16 | 2002-08-15 | Bayer Aktiengesellschaft | Uued bifenüül- ja bifenüülanaloogsed ühendid kui integriini antagonistid |
WO2001021584A1 (en) * | 1999-09-24 | 2001-03-29 | Genentech, Inc. | Tyrosine derivatives |
FR2812876B1 (fr) * | 2000-08-08 | 2002-09-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
PL376822A1 (pl) * | 2002-11-07 | 2006-01-09 | Merck & Co., Inc. | Pochodne fenyloalaniny jako inhibitory dipeptydylopeptydazy do leczenia lub zapobiegania cukrzycy |
EP1575911B1 (de) * | 2002-11-19 | 2010-01-13 | Galderma Research & Development | Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungen |
MXPA05013645A (es) * | 2003-06-20 | 2006-02-24 | Galderma Res & Dev | Nuevos compuestos moduladores de los receptores de tipo ppar gama y su utilizacion en composiciones cosmeticas o farmaceuticas. |
FR2892412B1 (fr) * | 2005-10-26 | 2008-05-16 | Galderma Res & Dev | Composes biaromatiques modulateurs des ppars |
-
2003
- 2003-11-18 EP EP03782482A patent/EP1575911B1/de not_active Expired - Lifetime
- 2003-11-18 DE DE60330997T patent/DE60330997D1/de not_active Expired - Lifetime
- 2003-11-18 AT AT03782482T patent/ATE455096T1/de not_active IP Right Cessation
- 2003-11-18 BR BR0314898-0A patent/BR0314898A/pt not_active IP Right Cessation
- 2003-11-18 JP JP2004570287A patent/JP2006506446A/ja not_active Withdrawn
- 2003-11-18 AU AU2003290120A patent/AU2003290120A1/en not_active Abandoned
- 2003-11-18 CA CA2505299A patent/CA2505299C/en not_active Expired - Fee Related
- 2003-11-18 MX MXPA05005171A patent/MXPA05005171A/es unknown
- 2003-11-18 PL PL378238A patent/PL378238A1/pl unknown
- 2003-11-18 WO PCT/EP2003/014861 patent/WO2004046091A2/en active Application Filing
- 2003-11-18 RU RU2005119167/04A patent/RU2005119167A/ru not_active Application Discontinuation
-
2005
- 2005-05-18 US US11/131,302 patent/US7452878B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 US US12/266,096 patent/US7807669B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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ATE455096T1 (de) | 2010-01-15 |
CA2505299A1 (en) | 2004-06-03 |
US20090062340A1 (en) | 2009-03-05 |
RU2005119167A (ru) | 2006-01-20 |
US7452878B2 (en) | 2008-11-18 |
MXPA05005171A (es) | 2005-10-26 |
EP1575911B1 (de) | 2010-01-13 |
EP1575911A2 (de) | 2005-09-21 |
AU2003290120A1 (en) | 2004-06-15 |
JP2006506446A (ja) | 2006-02-23 |
PL378238A1 (pl) | 2006-03-20 |
US20050256116A1 (en) | 2005-11-17 |
CA2505299C (en) | 2012-11-13 |
US7807669B2 (en) | 2010-10-05 |
WO2004046091A3 (en) | 2004-07-29 |
BR0314898A (pt) | 2005-08-02 |
WO2004046091A2 (en) | 2004-06-03 |
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