DE60326541D1 - Entgegenwirken bioprothetischer kalzifizierung - Google Patents

Entgegenwirken bioprothetischer kalzifizierung

Info

Publication number
DE60326541D1
DE60326541D1 DE60326541T DE60326541T DE60326541D1 DE 60326541 D1 DE60326541 D1 DE 60326541D1 DE 60326541 T DE60326541 T DE 60326541T DE 60326541 T DE60326541 T DE 60326541T DE 60326541 D1 DE60326541 D1 DE 60326541D1
Authority
DE
Germany
Prior art keywords
calcification
polyphosphonate
polyepoxide
functional group
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60326541T
Other languages
English (en)
Inventor
Robert J Levy
Ivan Alferiev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital of Philadelphia CHOP
Original Assignee
Childrens Hospital of Philadelphia CHOP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital of Philadelphia CHOP filed Critical Childrens Hospital of Philadelphia CHOP
Application granted granted Critical
Publication of DE60326541D1 publication Critical patent/DE60326541D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
DE60326541T 2002-01-07 2003-01-06 Entgegenwirken bioprothetischer kalzifizierung Expired - Lifetime DE60326541D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34481002P 2002-01-07 2002-01-07
PCT/US2003/000006 WO2003057177A2 (en) 2002-01-07 2003-01-06 Counteracting bioprosthetic calcification

Publications (1)

Publication Number Publication Date
DE60326541D1 true DE60326541D1 (de) 2009-04-23

Family

ID=23352138

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60326541T Expired - Lifetime DE60326541D1 (de) 2002-01-07 2003-01-06 Entgegenwirken bioprothetischer kalzifizierung

Country Status (7)

Country Link
US (1) US7156881B2 (de)
EP (1) EP1471921B1 (de)
JP (1) JP2005521437A (de)
AT (1) ATE424830T1 (de)
AU (1) AU2003201493A1 (de)
DE (1) DE60326541D1 (de)
WO (1) WO2003057177A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989157B2 (en) * 2005-01-11 2011-08-02 Medtronic, Inc. Solution for storing bioprosthetic tissue used in a biological prosthesis
US8071574B2 (en) 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
US20070237802A1 (en) * 2006-04-11 2007-10-11 Medtronic Vascular, Inc. Inhibition of Calcification on an Endovascular Device
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196409A (en) 1989-08-20 1993-03-23 Yissum, Research Development Company Of The Hebrew University Of Jerusalem Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism
US5436291A (en) 1992-07-09 1995-07-25 University Of Michigan, The Board Of . . . Calcification-resistant synthetic biomaterials
US5674298A (en) * 1994-10-21 1997-10-07 The Board Of Regents Of The University Of Michigan Calcification-resistant bioprosthetic tissue and methods of making same
JP4733888B2 (ja) 1999-07-23 2011-07-27 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 誘導体化ポリウレタン組成物およびその製造方法
US6391538B1 (en) 2000-02-09 2002-05-21 The Children's Hospital Of Philadelphia Stabilization of implantable bioprosthetic tissue

Also Published As

Publication number Publication date
WO2003057177A3 (en) 2004-07-08
EP1471921A2 (de) 2004-11-03
AU2003201493A8 (en) 2003-07-24
AU2003201493A1 (en) 2003-07-24
EP1471921B1 (de) 2009-03-11
WO2003057177A2 (en) 2003-07-17
US20030196274A1 (en) 2003-10-23
US7156881B2 (en) 2007-01-02
JP2005521437A (ja) 2005-07-21
ATE424830T1 (de) 2009-03-15
EP1471921A4 (de) 2007-06-20

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