PE20080317A1 - Sintesis de compuestos intermediarios derivados de benzodioxano - Google Patents

Sintesis de compuestos intermediarios derivados de benzodioxano

Info

Publication number
PE20080317A1
PE20080317A1 PE2007000475A PE2007000475A PE20080317A1 PE 20080317 A1 PE20080317 A1 PE 20080317A1 PE 2007000475 A PE2007000475 A PE 2007000475A PE 2007000475 A PE2007000475 A PE 2007000475A PE 20080317 A1 PE20080317 A1 PE 20080317A1
Authority
PE
Peru
Prior art keywords
benzodioxane
group
synthesis
compounds derived
amino
Prior art date
Application number
PE2007000475A
Other languages
English (en)
Inventor
Qing Yu
Michel Bernatchez
Rocco J Galante
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38567078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080317(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080317A1 publication Critical patent/PE20080317A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA UN METODO DE PREPARACION DE UN DERIVADO DE BENZODIOXANO DE FORMULA (A), DONDE x ES UN ENTERO DE 0 A 3; y ES UN ENTERO DE 0 A 5; R1 ES FENILO, CIANO, C(O)NH2, ENTRE OTROS; R2 ES FENILO, CIANO, HALOGENO, ENTRE OTROS; PG2 Y PG3 SON GRUPOS PROTECTORES AMINO O UNO DE ELLOS ES HIDROGENO Y EL OTRO ES UN GRUPO AMINO PROTECTOR O EL GRUPO -N(PG2)(PG3) ES UN GRUPO AZIDO; DONDE DICHO PROCEDIMIENTO COMPRENDE CICLAR UN COMPUESTO DE FORMULA (B), DONDE PG2 Y PG3 SON UN GRUPO AMINO PROTECTOR; LG ES UN GRUPO SALIENTE; x, y, R1 Y R2 SON COMO SE DESCRIBIO ANTERIORMENTE. DICHOS COMPUESTOS DERIVADOS DE BENZODIOXANO SIRVEN COMO INTERMEDIARIOS EN LA PREPARACION DE COMPUESTOS DERIVADOS DE BENZODIOXANO Y/O BENZODIOXOLANO QUE SON AGONISTAS O AGONISTAS PARCIALES DE 5HT2C Y QUE SON UTILES EN EL TRATAMIENTO DE LA ESQUIZOFRENIA, TRASTORNOS PSICOTICOS, ALUCINATORIOS, ENTRE OTROS
PE2007000475A 2006-04-18 2007-04-18 Sintesis de compuestos intermediarios derivados de benzodioxano PE20080317A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79283006P 2006-04-18 2006-04-18
US85438306P 2006-10-25 2006-10-25

Publications (1)

Publication Number Publication Date
PE20080317A1 true PE20080317A1 (es) 2008-06-11

Family

ID=38567078

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000475A PE20080317A1 (es) 2006-04-18 2007-04-18 Sintesis de compuestos intermediarios derivados de benzodioxano

Country Status (6)

Country Link
US (1) US20070255065A1 (es)
AR (1) AR060493A1 (es)
CA (1) CA2648612A1 (es)
PE (1) PE20080317A1 (es)
TW (1) TW200808754A (es)
WO (1) WO2007123942A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011519839A (ja) * 2008-04-29 2011-07-14 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ ドーパミン神経伝達のモジュレーター
MX2010011498A (es) * 2008-04-29 2010-11-12 Nsab Af Neurosearch Sweden Ab Moduladores de neurotransmision de dopamina.
MX2010011724A (es) * 2008-04-29 2010-11-30 Nsab Af Neurosearch Sweden Ab Moduladores de neurotransmision de dopamina.
GB201801128D0 (en) * 2018-01-24 2018-03-07 Univ Oxford Innovation Ltd Compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2791675B1 (fr) * 1999-03-30 2001-05-04 Synthelabo Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique
US6559169B2 (en) * 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041697B2 (en) * 2002-09-12 2006-05-09 Wyeth Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
US7135479B2 (en) * 2002-09-12 2006-11-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
GT200600167A (es) * 2005-04-22 2007-03-14 Derivados de dihidrobenzofurano y usos de los mismos
GT200600159A (es) * 2005-04-22 2007-03-14 Derivados benzodioxano y benzodioxolano y usos de los mismos

Also Published As

Publication number Publication date
TW200808754A (en) 2008-02-16
WO2007123942A3 (en) 2007-12-21
AR060493A1 (es) 2008-06-18
US20070255065A1 (en) 2007-11-01
CA2648612A1 (en) 2007-11-01
WO2007123942A2 (en) 2007-11-01

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Legal Events

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