DE60323964D1 - Poly(alkylenoxide) von reduziertem format mit reboxetin zur verringerung der bildung von verunreinigungen - Google Patents

Poly(alkylenoxide) von reduziertem format mit reboxetin zur verringerung der bildung von verunreinigungen

Info

Publication number
DE60323964D1
DE60323964D1 DE60323964T DE60323964T DE60323964D1 DE 60323964 D1 DE60323964 D1 DE 60323964D1 DE 60323964 T DE60323964 T DE 60323964T DE 60323964 T DE60323964 T DE 60323964T DE 60323964 D1 DE60323964 D1 DE 60323964D1
Authority
DE
Germany
Prior art keywords
reboxetin
pollution
poly
formation
reduce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60323964T
Other languages
English (en)
Inventor
Sylvia L Seroff
Noymi V Yam
Atul D Ayer
Andrew C Lam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE60323964D1 publication Critical patent/DE60323964D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)
DE60323964T 2002-04-29 2003-04-28 Poly(alkylenoxide) von reduziertem format mit reboxetin zur verringerung der bildung von verunreinigungen Expired - Lifetime DE60323964D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37648102P 2002-04-29 2002-04-29
PCT/US2003/013156 WO2003092649A2 (en) 2002-04-29 2003-04-28 Reduced formate poly(alkylene oxides) with secondary amines for reducing impurity formation

Publications (1)

Publication Number Publication Date
DE60323964D1 true DE60323964D1 (de) 2008-11-20

Family

ID=29401353

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60323964T Expired - Lifetime DE60323964D1 (de) 2002-04-29 2003-04-28 Poly(alkylenoxide) von reduziertem format mit reboxetin zur verringerung der bildung von verunreinigungen

Country Status (11)

Country Link
US (1) US20040033263A1 (de)
EP (1) EP1503732B1 (de)
JP (1) JP4717436B2 (de)
KR (1) KR100887982B1 (de)
AR (1) AR039492A1 (de)
AT (1) ATE410146T1 (de)
AU (1) AU2003243172A1 (de)
CA (1) CA2483656C (de)
DE (1) DE60323964D1 (de)
TW (1) TWI343824B (de)
WO (1) WO2003092649A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0203296D0 (en) 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
US20100069389A1 (en) * 2008-09-06 2010-03-18 Bionevia Pharmaceuticals, Inc. Novel forms of reboxetine
TWI478712B (zh) 2008-09-30 2015-04-01 Astellas Pharma Inc 釋控性醫藥組成物
PT2554168T (pt) 2010-03-29 2018-02-28 Astellas Pharma Inc Composição farmacêutica de libertação controlada

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1156807A (fr) * 1953-12-28 1958-05-21 Hoechst Ag Procédé permettant de préparer des huiles et des cires chloro-fluoro-carbonées
BE557908A (de) * 1956-05-29
NL108011C (de) * 1957-06-27
US3135705A (en) * 1959-05-11 1964-06-02 Hercules Powder Co Ltd Polymeric epoxides
US3219591A (en) * 1958-05-29 1965-11-23 Hercules Powder Co Ltd Organoaluminum oxide catalyst composition
US3037943A (en) * 1958-12-29 1962-06-05 Union Carbide Corp Preparation of catalysts for the polymerization of epoxides
US3403114A (en) * 1967-02-17 1968-09-24 Hercules Inc Polymers of amino epoxides
US4097652A (en) * 1975-08-28 1978-06-27 Albany International Corp. Poly (ethylene oxide) monofilament
US4193892A (en) * 1976-11-11 1980-03-18 Union Carbide Corporation Process for preparing olefin oxide polymerization catalysts by aging the catalysts
US4169062A (en) * 1977-05-12 1979-09-25 Southern Sizing Co. Random copolymers of polyoxyethylene polyoxypropylene glycol monoester, process of making the same and textile fiber containing the same
US4267309A (en) * 1978-07-28 1981-05-12 Union Carbide Corporation Process for preparing olefin oxide polymerization catalysts
US4211681A (en) * 1978-08-16 1980-07-08 Union Carbide Corporation Poly(ethylene oxide) compositions
US4277366A (en) * 1979-09-26 1981-07-07 Union Carbide Corporation Poly(alkylene oxide) composition
JPS56104936A (en) * 1980-01-24 1981-08-21 Dai Ichi Kogyo Seiyaku Co Ltd Purification of polyether polyol
US4667013A (en) * 1986-05-02 1987-05-19 Union Carbide Corporation Process for alkylene oxide polymerization
US4946687A (en) * 1987-10-02 1990-08-07 Alza Corporation Dosage form for treating cardiovascular diseases
US5030456A (en) * 1988-11-07 1991-07-09 Alza Corporation Dosage form for treating cardiovascular diseases
US5216122A (en) * 1991-05-21 1993-06-01 Union Carbide Chemicals & Plastics Technology Corporation Removal of residual ethylene oxide from poly(ethylene oxide)
JP3073054B2 (ja) * 1991-07-11 2000-08-07 住友精化株式会社 アルキレンオキシド重合体の製造方法
US5804209A (en) * 1994-06-16 1998-09-08 Pharmacia S.P.A. Bioadhesive starches and process for their preparation
JP4730985B2 (ja) * 1997-09-10 2011-07-20 武田薬品工業株式会社 安定化された医薬製剤
AU9214498A (en) * 1997-09-23 1999-04-12 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
UA56257C2 (uk) * 1997-09-23 2003-05-15 Елі Ліллі Енд Компані Спосіб лікування неадекватної визивної поведінки
JP2001520195A (ja) * 1997-10-17 2001-10-30 イーライ・リリー・アンド・カンパニー 医薬の増強
SE9902364D0 (sv) * 1999-06-21 1999-06-21 Astra Ab New process
CO5210862A1 (es) * 1999-09-15 2002-10-30 Alza Corp Formas de dosificacion y metodos para proporcionar efectiva terapia de reboxetina con dosificacion de una vez al dia
ATE328028T1 (de) * 2001-05-01 2006-06-15 Union Carbide Chem Plastic Pharmazeutische zusammensetzung enthaltend polyalkylenoxide mit verringerten mengen an ameisensäure und ameisensäurederivaten

Also Published As

Publication number Publication date
KR20050016374A (ko) 2005-02-21
CA2483656C (en) 2013-06-18
TW200400057A (en) 2004-01-01
EP1503732B1 (de) 2008-10-08
KR100887982B1 (ko) 2009-03-09
WO2003092649A3 (en) 2004-01-22
JP4717436B2 (ja) 2011-07-06
US20040033263A1 (en) 2004-02-19
JP2005525406A (ja) 2005-08-25
TWI343824B (en) 2011-06-21
EP1503732A2 (de) 2005-02-09
AR039492A1 (es) 2005-02-23
WO2003092649A2 (en) 2003-11-13
AU2003243172A1 (en) 2003-11-17
ATE410146T1 (de) 2008-10-15
CA2483656A1 (en) 2003-11-13

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