DE60322396D1 - Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrobenzol) - Google Patents
Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrobenzol)Info
- Publication number
- DE60322396D1 DE60322396D1 DE60322396T DE60322396T DE60322396D1 DE 60322396 D1 DE60322396 D1 DE 60322396D1 DE 60322396 T DE60322396 T DE 60322396T DE 60322396 T DE60322396 T DE 60322396T DE 60322396 D1 DE60322396 D1 DE 60322396D1
- Authority
- DE
- Germany
- Prior art keywords
- dihydro
- dimethyl
- nitrobenzole
- isobutylmethyl
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 title 1
- ZYVYEJXMYBUCMN-UHFFFAOYSA-N 1-methoxy-2-methylpropane Chemical group COCC(C)C ZYVYEJXMYBUCMN-UHFFFAOYSA-N 0.000 abstract 1
- MGPMEYRPZPIHIL-UHFFFAOYSA-N 2-methylpropyl 2-[(2-nitrophenyl)methylidene]-3-oxobutanoate Chemical compound CC(C)COC(=O)C(C(C)=O)=CC1=CC=CC=C1[N+]([O-])=O MGPMEYRPZPIHIL-UHFFFAOYSA-N 0.000 abstract 1
- XKORCTIIRYKLLG-ARJAWSKDSA-N methyl (z)-3-aminobut-2-enoate Chemical compound COC(=O)\C=C(\C)N XKORCTIIRYKLLG-ARJAWSKDSA-N 0.000 abstract 1
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000227 nisoldipine Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI001445A ITMI20021445A1 (it) | 2002-07-01 | 2002-07-01 | Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina) |
| PCT/EP2003/006755 WO2004002958A1 (en) | 2002-07-01 | 2003-06-26 | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60322396D1 true DE60322396D1 (de) | 2008-09-04 |
Family
ID=11450118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60322396T Expired - Lifetime DE60322396D1 (de) | 2002-07-01 | 2003-06-26 | Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrobenzol) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7060838B2 (it) |
| EP (1) | EP1532110B1 (it) |
| JP (1) | JP2006512287A (it) |
| AT (1) | ATE402146T1 (it) |
| AU (1) | AU2003246594A1 (it) |
| DE (1) | DE60322396D1 (it) |
| ES (1) | ES2311112T3 (it) |
| IT (1) | ITMI20021445A1 (it) |
| PT (1) | PT1532110E (it) |
| WO (1) | WO2004002958A1 (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7490255B2 (en) | 2006-06-30 | 2009-02-10 | Intel Corporation | Power efficient flow control model for USB asynchronous transfers |
| CN108752263B (zh) * | 2018-06-08 | 2021-10-26 | 迪嘉药业集团有限公司 | 一种高纯度硝苯地平结晶的制备方法 |
| CN116425635A (zh) * | 2020-03-24 | 2023-07-14 | 合肥立方制药股份有限公司 | 一种使用组合催化剂合成硝苯地平中间体的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
| US4600778A (en) | 1983-04-05 | 1986-07-15 | Bayer Aktiengesellschaft | Process for the preparation of 1,4-dihydropyridinedicarboxylic esters |
-
2002
- 2002-07-01 IT IT2002MI001445A patent/ITMI20021445A1/it unknown
-
2003
- 2003-06-26 PT PT03761517T patent/PT1532110E/pt unknown
- 2003-06-26 ES ES03761517T patent/ES2311112T3/es not_active Expired - Lifetime
- 2003-06-26 EP EP03761517A patent/EP1532110B1/en not_active Expired - Lifetime
- 2003-06-26 DE DE60322396T patent/DE60322396D1/de not_active Expired - Lifetime
- 2003-06-26 AT AT03761517T patent/ATE402146T1/de not_active IP Right Cessation
- 2003-06-26 JP JP2004516691A patent/JP2006512287A/ja active Pending
- 2003-06-26 AU AU2003246594A patent/AU2003246594A1/en not_active Abandoned
- 2003-06-26 US US10/520,066 patent/US7060838B2/en not_active Expired - Fee Related
- 2003-06-26 WO PCT/EP2003/006755 patent/WO2004002958A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP1532110A1 (en) | 2005-05-25 |
| ES2311112T3 (es) | 2009-02-01 |
| US20050240022A1 (en) | 2005-10-27 |
| EP1532110B1 (en) | 2008-07-23 |
| ITMI20021445A1 (it) | 2004-01-02 |
| WO2004002958A1 (en) | 2004-01-08 |
| PT1532110E (pt) | 2008-10-31 |
| ITMI20021445A0 (it) | 2002-07-01 |
| ATE402146T1 (de) | 2008-08-15 |
| US7060838B2 (en) | 2006-06-13 |
| AU2003246594A1 (en) | 2004-01-19 |
| JP2006512287A (ja) | 2006-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |