ITMI20021445A0 - Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina) - Google Patents

Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina)

Info

Publication number
ITMI20021445A0
ITMI20021445A0 IT2002MI001445A ITMI20021445A ITMI20021445A0 IT MI20021445 A0 ITMI20021445 A0 IT MI20021445A0 IT 2002MI001445 A IT2002MI001445 A IT 2002MI001445A IT MI20021445 A ITMI20021445 A IT MI20021445A IT MI20021445 A0 ITMI20021445 A0 IT MI20021445A0
Authority
IT
Italy
Prior art keywords
nisoldipine
dicarboxylate
nitrophenyl
pyridin
dihydro
Prior art date
Application number
IT2002MI001445A
Other languages
English (en)
Inventor
Massimo Ferrari
Marcello Ghezzi
Manuel Alberelli
Alberto Ambrosini
Original Assignee
Erregierre Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erregierre Spa filed Critical Erregierre Spa
Priority to IT2002MI001445A priority Critical patent/ITMI20021445A1/it
Publication of ITMI20021445A0 publication Critical patent/ITMI20021445A0/it
Priority to DE60322396T priority patent/DE60322396D1/de
Priority to EP03761517A priority patent/EP1532110B1/en
Priority to US10/520,066 priority patent/US7060838B2/en
Priority to PT03761517T priority patent/PT1532110E/pt
Priority to PCT/EP2003/006755 priority patent/WO2004002958A1/en
Priority to JP2004516691A priority patent/JP2006512287A/ja
Priority to AT03761517T priority patent/ATE402146T1/de
Priority to AU2003246594A priority patent/AU2003246594A1/en
Priority to ES03761517T priority patent/ES2311112T3/es
Publication of ITMI20021445A1 publication Critical patent/ITMI20021445A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
IT2002MI001445A 2002-07-01 2002-07-01 Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina) ITMI20021445A1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT2002MI001445A ITMI20021445A1 (it) 2002-07-01 2002-07-01 Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina)
ES03761517T ES2311112T3 (es) 2002-07-01 2003-06-26 Procedimiento industrial para la sintesis de dicarboxilato de isobutilmetil 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridina (nisoldipina).
PT03761517T PT1532110E (pt) 2002-07-01 2003-06-26 Processo industrial para a síntese do dicarboxilato de isobutil metil 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)- 3,5-piridina (nisoldipina)
EP03761517A EP1532110B1 (en) 2002-07-01 2003-06-26 Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)
US10/520,066 US7060838B2 (en) 2002-07-01 2003-06-26 Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)
DE60322396T DE60322396D1 (de) 2002-07-01 2003-06-26 Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrobenzol)
PCT/EP2003/006755 WO2004002958A1 (en) 2002-07-01 2003-06-26 Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)
JP2004516691A JP2006512287A (ja) 2002-07-01 2003-06-26 イソブチルメチル１，４−ジヒドロ−２，６−ジメチル−４−（２−ニトロフェニル）−３，５−ピリジンジカルボン酸塩（ニソルジピン）の合成のための工業的製法
AT03761517T ATE402146T1 (de) 2002-07-01 2003-06-26 Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2- nitrobenzol)
AU2003246594A AU2003246594A1 (en) 2002-07-01 2003-06-26 Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI001445A ITMI20021445A1 (it) 2002-07-01 2002-07-01 Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina)

Publications (2)

Publication Number Publication Date
ITMI20021445A0 true ITMI20021445A0 (it) 2002-07-01
ITMI20021445A1 ITMI20021445A1 (it) 2004-01-02

Family

ID=11450118

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002MI001445A ITMI20021445A1 (it) 2002-07-01 2002-07-01 Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina)

Country Status (10)

Country Link
US (1) US7060838B2 (it)
EP (1) EP1532110B1 (it)
JP (1) JP2006512287A (it)
AT (1) ATE402146T1 (it)
AU (1) AU2003246594A1 (it)
DE (1) DE60322396D1 (it)
ES (1) ES2311112T3 (it)
IT (1) ITMI20021445A1 (it)
PT (1) PT1532110E (it)
WO (1) WO2004002958A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7490255B2 (en) 2006-06-30 2009-02-10 Intel Corporation Power efficient flow control model for USB asynchronous transfers
CN108752263B (zh) * 2018-06-08 2021-10-26 迪嘉药业集团有限公司 一种高纯度硝苯地平结晶的制备方法
CN116425635A (zh) * 2020-03-24 2023-07-14 合肥立方制药股份有限公司 一种使用组合催化剂合成硝苯地平中间体的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154839A (en) 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
US4600778A (en) 1983-04-05 1986-07-15 Bayer Aktiengesellschaft Process for the preparation of 1,4-dihydropyridinedicarboxylic esters

Also Published As

Publication number Publication date
ATE402146T1 (de) 2008-08-15
PT1532110E (pt) 2008-10-31
EP1532110A1 (en) 2005-05-25
US20050240022A1 (en) 2005-10-27
ES2311112T3 (es) 2009-02-01
WO2004002958A1 (en) 2004-01-08
EP1532110B1 (en) 2008-07-23
ITMI20021445A1 (it) 2004-01-02
AU2003246594A1 (en) 2004-01-19
JP2006512287A (ja) 2006-04-13
DE60322396D1 (de) 2008-09-04
US7060838B2 (en) 2006-06-13

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