DE60318900D1 - Nukleinsäuren, polypeptide und verfahren zur modulierung der apoptose - Google Patents

Nukleinsäuren, polypeptide und verfahren zur modulierung der apoptose

Info

Publication number
DE60318900D1
DE60318900D1 DE60318900T DE60318900T DE60318900D1 DE 60318900 D1 DE60318900 D1 DE 60318900D1 DE 60318900 T DE60318900 T DE 60318900T DE 60318900 T DE60318900 T DE 60318900T DE 60318900 D1 DE60318900 D1 DE 60318900D1
Authority
DE
Germany
Prior art keywords
apoptosis
eif
specific eif
polypeptides
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318900T
Other languages
German (de)
English (en)
Inventor
John E Thompson
Catherine Taylor
Dominic Cliche
Charles Dinarello
Leonid Reznikov
Benjamin Pomerantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eloxx Pharmaceuticals Inc
Original Assignee
Senesco Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senesco Technologies Inc filed Critical Senesco Technologies Inc
Application granted granted Critical
Publication of DE60318900D1 publication Critical patent/DE60318900D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60318900T 2002-10-23 2003-10-22 Nukleinsäuren, polypeptide und verfahren zur modulierung der apoptose Expired - Lifetime DE60318900D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/277,969 US7217517B2 (en) 2001-07-23 2002-10-23 Nucleic acids, polypeptides, and methods for modulating apoptosis
PCT/US2003/033463 WO2004037984A2 (en) 2002-10-23 2003-10-22 Nucleic acids, polypeptides, and methods for modulating apoptosis

Publications (1)

Publication Number Publication Date
DE60318900D1 true DE60318900D1 (de) 2008-03-13

Family

ID=32174556

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318900T Expired - Lifetime DE60318900D1 (de) 2002-10-23 2003-10-22 Nukleinsäuren, polypeptide und verfahren zur modulierung der apoptose

Country Status (12)

Country Link
US (1) US7217517B2 (https=)
EP (1) EP1578452B1 (https=)
JP (1) JP4890763B2 (https=)
KR (1) KR20050046015A (https=)
CN (1) CN1732018B (https=)
AT (1) ATE384740T1 (https=)
AU (1) AU2003301585B2 (https=)
CA (1) CA2503442C (https=)
DE (1) DE60318900D1 (https=)
NZ (1) NZ540105A (https=)
TW (1) TWI324070B (https=)
WO (1) WO2004037984A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
AU2004217437B2 (en) * 2003-03-05 2009-11-19 Senesco Technologies, Inc. Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
US20140371299A1 (en) * 2004-06-07 2014-12-18 Senesco Technologies, Inc. Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
AU2005269647B2 (en) * 2004-07-20 2009-11-12 Senesco Technologies, Inc. Use of apoptosis-specific eIF-5A siRNAs and antisense polynucleotides to inhibit/suppress an inflammatory response
CA2588129A1 (en) * 2004-12-03 2006-06-08 Senesco Technologies, Inc. Apoptosis-specific eif-5a and polynucleotides encoding same
EP1824982A2 (en) * 2004-12-03 2007-08-29 Senesco Technologies, Inc. Methods of increasing seed yield
JP5578522B2 (ja) * 2008-05-27 2014-08-27 義規 世古 アポトーシス誘導薬
KR102441107B1 (ko) 2014-11-07 2022-09-13 후지쿠라 가세이 가부시키가이샤 데옥시하이푸신·신타제 유전자를 지표로서 사용하는 동맥 경화 및 암의 검출 방법
EP3807644A4 (en) * 2018-06-12 2022-07-06 Angiex, Inc. ANTIBODY-OLIGONUCLEOTIDE CONJUGATES
CN114231551B (zh) * 2021-12-24 2023-09-29 云南大学 蛋白在促进昆虫淋巴细胞凋亡和/或防治害虫中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344846A (en) 1992-12-30 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for inhibiting deoxyhypusine synthase and the growth of cells
AU4665196A (en) * 1995-02-13 1996-09-04 Novartis Ag Eukaryotic initiation factor 5A (eIF-5A) mutants
US5849587A (en) 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
CA2296105A1 (en) 1997-06-30 1999-01-14 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel inhibitor of cellular proliferation
US6538182B1 (en) 1999-07-06 2003-03-25 Senesco, Inc. DNA encoding a plant deoxyhypusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants
CA2376065A1 (en) 1999-08-06 2001-02-15 Pharmacia & Upjohn Company Crystallization and structure determination of staphylococcus aureus elongation factor p
US7166467B2 (en) 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis

Also Published As

Publication number Publication date
WO2004037984A2 (en) 2004-05-06
KR20050046015A (ko) 2005-05-17
EP1578452A2 (en) 2005-09-28
US7217517B2 (en) 2007-05-15
TWI324070B (en) 2010-05-01
AU2003301585A1 (en) 2004-05-13
JP2006507816A (ja) 2006-03-09
CN1732018B (zh) 2014-09-10
ATE384740T1 (de) 2008-02-15
JP4890763B2 (ja) 2012-03-07
EP1578452B1 (en) 2008-01-23
TW200501988A (en) 2005-01-16
CA2503442A1 (en) 2004-05-06
CN1732018A (zh) 2006-02-08
EP1578452A4 (en) 2006-01-11
CA2503442C (en) 2014-02-18
WO2004037984A3 (en) 2005-04-14
US20030144238A1 (en) 2003-07-31
NZ540105A (en) 2006-10-27
AU2003301585B2 (en) 2009-08-20

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