DE60311861D1 - Pyrazolochinoline mit immunmodulierenderwirkung - Google Patents
Pyrazolochinoline mit immunmodulierenderwirkungInfo
- Publication number
- DE60311861D1 DE60311861D1 DE60311861T DE60311861T DE60311861D1 DE 60311861 D1 DE60311861 D1 DE 60311861D1 DE 60311861 T DE60311861 T DE 60311861T DE 60311861 T DE60311861 T DE 60311861T DE 60311861 D1 DE60311861 D1 DE 60311861D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrazolochinoline
- methods
- heterocyclic compounds
- relates
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- UXYHZIYEDDINQH-UHFFFAOYSA-N C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical compound C1=CNC2=C3C=NN=C3C=CC2=C1 UXYHZIYEDDINQH-UHFFFAOYSA-N 0.000 title 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 abstract 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42824002P | 2002-11-22 | 2002-11-22 | |
SE0203471A SE0203471D0 (sv) | 2002-11-22 | 2002-11-22 | Immunomodulatory compunds |
SE0203471 | 2002-11-22 | ||
US428240P | 2002-11-22 | ||
SE0301299A SE0301299D0 (sv) | 2003-05-06 | 2003-05-06 | Immunomodulatory compounds |
SE0301299 | 2003-05-06 | ||
US48212203P | 2003-06-25 | 2003-06-25 | |
US482122P | 2003-06-25 | ||
SE0301851 | 2003-06-25 | ||
SE0301851A SE0301851D0 (sv) | 2003-06-25 | 2003-06-25 | Immunomodulatory compounds |
PCT/SE2003/001805 WO2004048378A1 (en) | 2002-11-22 | 2003-11-21 | Pyrazoloquinolines with immunomodulating activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60311861D1 true DE60311861D1 (de) | 2007-03-29 |
DE60311861T2 DE60311861T2 (de) | 2007-11-22 |
Family
ID=32398347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60311861T Expired - Lifetime DE60311861T2 (de) | 2002-11-22 | 2003-11-21 | Pyrazolochinoline mit immunmodulierender wirkung |
Country Status (14)
Country | Link |
---|---|
US (2) | US7081456B2 (de) |
EP (2) | EP1813616B1 (de) |
JP (1) | JP2006509047A (de) |
CN (1) | CN100347173C (de) |
AT (1) | ATE353898T1 (de) |
AU (1) | AU2003279687A1 (de) |
CA (1) | CA2506524A1 (de) |
DE (1) | DE60311861T2 (de) |
ES (1) | ES2282693T3 (de) |
HK (1) | HK1086562A1 (de) |
NO (1) | NO20053018L (de) |
NZ (1) | NZ540081A (de) |
RU (1) | RU2328496C2 (de) |
WO (1) | WO2004048378A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60326639D1 (de) * | 2002-12-16 | 2009-04-23 | Active Biotech Ab | Tetrazyklische immunmodulierende verbindungen |
CA2519063C (en) | 2003-03-14 | 2011-05-10 | Avidex Limited | Immunomodulating heterocyclic compounds |
GB0325644D0 (en) | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
AU2004322237B2 (en) | 2004-08-09 | 2011-09-22 | Medigene Ag | Immunomodulating oxopyrrazolocinnolines as CD80 inhibitors |
WO2008043072A2 (en) * | 2006-10-05 | 2008-04-10 | Biogen Idec Inc. | Cd80 antagonists for treating neoplastic disorders |
EP2676666A1 (de) * | 2012-06-20 | 2013-12-25 | Eidgenössische Technische Hochschule Zürich (ETH) | Verbindungen zur Verwendung bei der Diagnose oder Therapie anfälliger atherosklerotischer Plaques |
CN102977095B (zh) * | 2012-12-03 | 2015-10-28 | 华东理工大学 | 吡唑并喹啉类化合物及其用途 |
US9809589B2 (en) * | 2012-12-22 | 2017-11-07 | Kbp Biosciences Co., Ltd. | Crystal form of compound used as mineralocorticoid receptor antagonist and preparation method therefor |
EP2883883A1 (de) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutische Ziele und Mittel zur Behandlung von ischämiebedingten Reperfusionsschäden |
CN110698456B (zh) * | 2019-11-06 | 2021-05-14 | 重庆医药高等专科学校 | 一种2,3-二氢硫代色烯-4-酮及其衍生物的合成方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4268516A (en) * | 1978-10-11 | 1981-05-19 | Pfizer Inc. | [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents |
US4312870A (en) * | 1979-06-21 | 1982-01-26 | Ciba-Geigy Corporation | Pyrazoloquinolines |
PH21213A (en) * | 1984-10-26 | 1987-08-21 | Fujisawa Pharmaceutical Co | Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same |
US4758427A (en) * | 1985-08-08 | 1988-07-19 | Ciba-Geigy Corporation | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
JPH05505180A (ja) * | 1990-02-02 | 1993-08-05 | ザ ブーツ カンパニー ピーエルシー | 治療薬 |
GB9002423D0 (en) * | 1990-02-06 | 1990-04-04 | Boots Co Plc | Therapeutic agents |
CN1069272A (zh) * | 1991-08-02 | 1993-02-24 | 布茨公司 | 制备苯并吡或噻喃并吡唑的方法 |
AR006520A1 (es) * | 1996-03-20 | 1999-09-08 | Astra Pharma Prod | Derivados de 2-arilpirazolisoquinolina y cinolinona y procedimiento para su preparacion. |
US6642249B2 (en) * | 2001-07-04 | 2003-11-04 | Active Biotech Ab | Immunomodulating compounds |
SE0102404D0 (sv) * | 2001-07-04 | 2001-07-04 | Active Biotech Ab | Novel immunomodulating compounds |
-
2003
- 2003-11-21 AT AT03773026T patent/ATE353898T1/de not_active IP Right Cessation
- 2003-11-21 US US10/717,519 patent/US7081456B2/en not_active Expired - Lifetime
- 2003-11-21 EP EP07102257A patent/EP1813616B1/de not_active Expired - Lifetime
- 2003-11-21 RU RU2005119639/04A patent/RU2328496C2/ru not_active IP Right Cessation
- 2003-11-21 NZ NZ540081A patent/NZ540081A/en unknown
- 2003-11-21 AU AU2003279687A patent/AU2003279687A1/en not_active Abandoned
- 2003-11-21 EP EP03773026A patent/EP1562944B1/de not_active Expired - Lifetime
- 2003-11-21 CA CA002506524A patent/CA2506524A1/en not_active Abandoned
- 2003-11-21 JP JP2005510306A patent/JP2006509047A/ja not_active Withdrawn
- 2003-11-21 WO PCT/SE2003/001805 patent/WO2004048378A1/en active IP Right Grant
- 2003-11-21 ES ES03773026T patent/ES2282693T3/es not_active Expired - Lifetime
- 2003-11-21 CN CNB2003801066699A patent/CN100347173C/zh not_active Expired - Fee Related
- 2003-11-21 DE DE60311861T patent/DE60311861T2/de not_active Expired - Lifetime
-
2005
- 2005-06-20 NO NO20053018A patent/NO20053018L/no not_active Application Discontinuation
-
2006
- 2006-05-30 US US11/442,548 patent/US7291612B2/en not_active Expired - Lifetime
- 2006-06-07 HK HK06106518A patent/HK1086562A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1729191A (zh) | 2006-02-01 |
CA2506524A1 (en) | 2004-06-10 |
RU2328496C2 (ru) | 2008-07-10 |
JP2006509047A (ja) | 2006-03-16 |
EP1813616A3 (de) | 2007-08-08 |
US20060217411A1 (en) | 2006-09-28 |
US20040116461A1 (en) | 2004-06-17 |
ATE353898T1 (de) | 2007-03-15 |
RU2005119639A (ru) | 2006-01-20 |
NO20053018L (no) | 2005-08-22 |
AU2003279687A1 (en) | 2004-06-18 |
WO2004048378A1 (en) | 2004-06-10 |
US7291612B2 (en) | 2007-11-06 |
EP1813616A2 (de) | 2007-08-01 |
EP1562944B1 (de) | 2007-02-14 |
DE60311861T2 (de) | 2007-11-22 |
CN100347173C (zh) | 2007-11-07 |
US20050203118A9 (en) | 2005-09-15 |
ES2282693T3 (es) | 2007-10-16 |
NZ540081A (en) | 2008-03-28 |
NO20053018D0 (no) | 2005-06-20 |
HK1086562A1 (en) | 2006-09-22 |
EP1813616B1 (de) | 2013-03-27 |
US7081456B2 (en) | 2006-07-25 |
EP1562944A1 (de) | 2005-08-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |