DE60308066T2 - Verfahren zur herstellung von hyperpolarisiertem 129xe - Google Patents

Verfahren zur herstellung von hyperpolarisiertem 129xe Download PDF

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Publication number
DE60308066T2
DE60308066T2 DE60308066T DE60308066T DE60308066T2 DE 60308066 T2 DE60308066 T2 DE 60308066T2 DE 60308066 T DE60308066 T DE 60308066T DE 60308066 T DE60308066 T DE 60308066T DE 60308066 T2 DE60308066 T2 DE 60308066T2
Authority
DE
Germany
Prior art keywords
xenon
mixture
hyperpolarized
solvents
dnp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60308066T
Other languages
German (de)
English (en)
Other versions
DE60308066D1 (de
Inventor
J.-H. - GE Healthcare AS ARDENKJAER-LARSEN
GE Healthcare AS Lennart HANSSON
GE Healthcare AS Haukur JOHANNESSON
GE Healthcare AS Rolf SERVIN
GE Healthcare AS Lars-Göran WISTRAND
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health AS filed Critical Amersham Health AS
Publication of DE60308066D1 publication Critical patent/DE60308066D1/de
Application granted granted Critical
Publication of DE60308066T2 publication Critical patent/DE60308066T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B23/00—Noble gases; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Atmospheric Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Semiconductor Lasers (AREA)
DE60308066T 2002-10-25 2003-10-24 Verfahren zur herstellung von hyperpolarisiertem 129xe Expired - Lifetime DE60308066T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20025124A NO20025124D0 (no) 2002-10-25 2002-10-25 Metode
NO20025124 2002-10-25
PCT/NO2003/000352 WO2004037296A2 (en) 2002-10-25 2003-10-24 Method for the production of hyperpolarized 129xe

Publications (2)

Publication Number Publication Date
DE60308066D1 DE60308066D1 (de) 2006-10-12
DE60308066T2 true DE60308066T2 (de) 2007-04-12

Family

ID=19914117

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60308066T Expired - Lifetime DE60308066T2 (de) 2002-10-25 2003-10-24 Verfahren zur herstellung von hyperpolarisiertem 129xe

Country Status (12)

Country Link
US (1) US8003077B2 (https=)
EP (1) EP1583563B1 (https=)
JP (1) JP4420224B2 (https=)
KR (1) KR20050074495A (https=)
CN (1) CN100435852C (https=)
AT (1) ATE337796T1 (https=)
CA (1) CA2500542A1 (https=)
DE (1) DE60308066T2 (https=)
ES (1) ES2274272T3 (https=)
NO (1) NO20025124D0 (https=)
RU (1) RU2337059C2 (https=)
WO (1) WO2004037296A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3998243B2 (ja) * 2003-01-10 2007-10-24 東横化学株式会社 核スピン偏極キセノンガスの製造方法及び製造装置
CA2622347C (en) * 2005-04-06 2011-01-25 Mallinckrodt Inc. Systems and methods for managing information relating to medical fluids and containers therefor
WO2007136439A2 (en) * 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US8623327B2 (en) 2006-06-19 2014-01-07 Beth Israel Deaconess Medical Center, Inc. Imaging agents for use in magnetic resonance blood flow/perfusion imaging
US9289518B2 (en) * 2008-08-22 2016-03-22 The Brigham And Women's Hospital Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE
US8697034B2 (en) * 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
US20100251732A1 (en) * 2009-04-06 2010-10-07 General Electric Company Apparatus and method for introduction of a material into a cryogenic system
ES2375390B1 (es) * 2009-10-26 2013-02-11 Consejo Superior De Investigaciones Científicas (Csic) Planta de recuperación de helio.
EP2348327B1 (en) * 2010-01-18 2013-11-27 Bruker BioSpin AG Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals
CN101961051A (zh) * 2010-09-08 2011-02-02 营口艾特科技有限公司 含氙气的液体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9305349D0 (en) * 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
IL126347A (en) * 1996-03-29 2003-11-23 Lawrence Berkeley National Lab Enhancement of nmr and mri in the presence of hyperpolarized noble gases
JP2002508687A (ja) 1997-06-19 2002-03-19 ナイコムド イメージング エーエス 磁気共鳴（ｍｒ）イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像（ｏｒｍｉ）法
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6125654A (en) * 1998-10-16 2000-10-03 Syracuse University Bulk production and usage of hyperpolarized 129 Xenon
GB0001727D0 (en) * 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas

Also Published As

Publication number Publication date
AU2003274845A1 (en) 2004-05-13
CA2500542A1 (en) 2004-05-06
JP2006503638A (ja) 2006-02-02
EP1583563A2 (en) 2005-10-12
DE60308066D1 (de) 2006-10-12
ES2274272T3 (es) 2007-05-16
JP4420224B2 (ja) 2010-02-24
WO2004037296A2 (en) 2004-05-06
CN1713925A (zh) 2005-12-28
NO20025124D0 (no) 2002-10-25
RU2337059C2 (ru) 2008-10-27
US8003077B2 (en) 2011-08-23
CN100435852C (zh) 2008-11-26
EP1583563B1 (en) 2006-08-30
KR20050074495A (ko) 2005-07-18
ATE337796T1 (de) 2006-09-15
US20060173282A1 (en) 2006-08-03
WO2004037296A3 (en) 2005-08-18
RU2005109267A (ru) 2005-12-10

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

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Representative=s name: J D REYNOLDS & CO., GB