DE60301725D1 - Dibenzodiazepin derivate, deren herstellung und verwendung - Google Patents

Dibenzodiazepin derivate, deren herstellung und verwendung

Info

Publication number
DE60301725D1
DE60301725D1 DE60301725T DE60301725T DE60301725D1 DE 60301725 D1 DE60301725 D1 DE 60301725D1 DE 60301725 T DE60301725 T DE 60301725T DE 60301725 T DE60301725 T DE 60301725T DE 60301725 D1 DE60301725 D1 DE 60301725D1
Authority
DE
Germany
Prior art keywords
preparation
sup
dibenzodiazepine derivatives
dibenzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60301725T
Other languages
English (en)
Other versions
DE60301725T2 (de
Inventor
Wilfried Lubisch
Roland Grandel
Wilfried Braje
Thomas Subkowski
Reinhold Mueller
Wolfgang Wernet
Karla Drescher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Publication of DE60301725D1 publication Critical patent/DE60301725D1/de
Application granted granted Critical
Publication of DE60301725T2 publication Critical patent/DE60301725T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE60301725T 2002-01-10 2003-01-10 Dibenzodiazepin derivate, deren herstellung und verwendung Expired - Lifetime DE60301725T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/041,556 US7026311B2 (en) 2002-01-10 2002-01-10 Dibenzodiazepine derivatives, their preparation and use
US41556 2002-01-10
PCT/EP2003/000192 WO2003057699A1 (en) 2002-01-10 2003-01-10 Dibenzodiazepine derivates, their preparation and use

Publications (2)

Publication Number Publication Date
DE60301725D1 true DE60301725D1 (de) 2006-02-09
DE60301725T2 DE60301725T2 (de) 2006-07-06

Family

ID=21917135

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60301725T Expired - Lifetime DE60301725T2 (de) 2002-01-10 2003-01-10 Dibenzodiazepin derivate, deren herstellung und verwendung

Country Status (11)

Country Link
US (1) US7026311B2 (de)
EP (1) EP1463731B1 (de)
JP (1) JP4308017B2 (de)
AT (1) ATE305472T1 (de)
AU (1) AU2003235806A1 (de)
CA (1) CA2472107C (de)
DE (1) DE60301725T2 (de)
DK (1) DK1463731T3 (de)
ES (1) ES2249718T3 (de)
MX (1) MXPA04006443A (de)
WO (1) WO2003057699A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2114948B1 (de) * 2006-12-28 2014-06-25 AbbVie Inc. Inhibitoren von poly(adp-ribose)polymerase
WO2009035997A2 (en) 2007-09-14 2009-03-19 Cara Therapeutics, Inc. Benzo-fused heterocycles
EP3144311A4 (de) 2014-05-16 2018-01-03 Shionogi & Co., Ltd. Tricyclisches heterocyclisches derivat mit hiv-replikationshemmender wirkung
EA201790082A1 (ru) * 2014-07-03 2017-08-31 Селджен Квонтисел Рисёрч, Инк. Ингибиторы лизин-специфической демитилазы-1
SG11201709634QA (en) * 2015-05-29 2017-12-28 Shionogi & Co Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity
EP3325623B3 (de) 2015-07-23 2021-01-20 Institut Curie Verwendung einer kombination aus dbait-molekül und parp-inhibitoren zur behandlung von krebs
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
CN111819282A (zh) 2018-03-13 2020-10-23 欧恩科斯欧公司 对抗癌症治疗中获得性耐药性的Dbait分子
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
CZ20012373A3 (cs) 1999-09-28 2002-05-15 Basf Aktiengesellschaft Derivát azepinindolu, jeho pouľití a farmaceutický prostředek, který ho obsahuje

Also Published As

Publication number Publication date
JP4308017B2 (ja) 2009-08-05
DK1463731T3 (da) 2006-02-13
US7026311B2 (en) 2006-04-11
US20030139394A1 (en) 2003-07-24
DE60301725T2 (de) 2006-07-06
EP1463731B1 (de) 2005-09-28
MXPA04006443A (es) 2004-10-04
AU2003235806A1 (en) 2003-07-24
CA2472107C (en) 2008-10-28
CA2472107A1 (en) 2003-07-17
JP2005516031A (ja) 2005-06-02
WO2003057699A1 (en) 2003-07-17
ES2249718T3 (es) 2006-04-01
EP1463731A1 (de) 2004-10-06
ATE305472T1 (de) 2005-10-15

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