DE60235770D1 - In ein lebervenenlumen injizierte nukleinsäure zur verabreichung an eine primatenleber - Google Patents
In ein lebervenenlumen injizierte nukleinsäure zur verabreichung an eine primatenleberInfo
- Publication number
- DE60235770D1 DE60235770D1 DE60235770T DE60235770T DE60235770D1 DE 60235770 D1 DE60235770 D1 DE 60235770D1 DE 60235770 T DE60235770 T DE 60235770T DE 60235770 T DE60235770 T DE 60235770T DE 60235770 D1 DE60235770 D1 DE 60235770D1
- Authority
- DE
- Germany
- Prior art keywords
- liver
- nucleic acid
- venuel
- primative
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004185 liver Anatomy 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 230000014509 gene expression Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 241000288906 Primates Species 0.000 abstract 1
- 210000002989 hepatic vein Anatomy 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/106—Primate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Environmental Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33798601P | 2001-12-05 | 2001-12-05 | |
| PCT/US2002/038894 WO2003048338A2 (en) | 2001-12-05 | 2002-12-05 | Nucleic acid injected into hepatic vein lumen and delivered to primate liver |
| US10/310,398 US7144869B2 (en) | 1995-12-13 | 2002-12-05 | Nucleic acid injected into hapatic vein lumen and delivered to primate liver |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60235770D1 true DE60235770D1 (de) | 2010-05-06 |
Family
ID=26977376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60235770T Expired - Lifetime DE60235770D1 (de) | 2001-12-05 | 2002-12-05 | In ein lebervenenlumen injizierte nukleinsäure zur verabreichung an eine primatenleber |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1461052B1 (de) |
| AT (1) | ATE461703T1 (de) |
| DE (1) | DE60235770D1 (de) |
| DK (1) | DK1461052T3 (de) |
| ES (1) | ES2339343T3 (de) |
| WO (1) | WO2003048338A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109266685B (zh) * | 2018-09-20 | 2022-08-19 | 赵永祥 | 快速基因编辑构建灵长类动物疾病模型的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265387B1 (en) * | 1995-10-11 | 2001-07-24 | Mirus, Inc. | Process of delivering naked DNA into a hepatocyte via bile duct |
| US20010008882A1 (en) * | 1997-11-21 | 2001-07-19 | Jon A. Wolff | Process of delivering a polynucleotide into a parenchymal cell |
| US20010009904A1 (en) * | 1997-12-30 | 2001-07-26 | Jon A. Wolff | Process of delivering a polynucleotide to a cell via the vascular system |
| US20020001574A1 (en) * | 1995-12-13 | 2002-01-03 | Jon A. Woiff | Process of delivering a polynucleotide to a muscle cell via the vascular system |
-
2002
- 2002-12-05 WO PCT/US2002/038894 patent/WO2003048338A2/en not_active Application Discontinuation
- 2002-12-05 EP EP02794164A patent/EP1461052B1/de not_active Expired - Lifetime
- 2002-12-05 ES ES02794164T patent/ES2339343T3/es not_active Expired - Lifetime
- 2002-12-05 AT AT02794164T patent/ATE461703T1/de active
- 2002-12-05 DE DE60235770T patent/DE60235770D1/de not_active Expired - Lifetime
- 2002-12-05 DK DK02794164.0T patent/DK1461052T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1461052A4 (de) | 2006-02-01 |
| EP1461052B1 (de) | 2010-03-24 |
| ATE461703T1 (de) | 2010-04-15 |
| WO2003048338A3 (en) | 2003-12-04 |
| WO2003048338A2 (en) | 2003-06-12 |
| ES2339343T3 (es) | 2010-05-19 |
| EP1461052A2 (de) | 2004-09-29 |
| DK1461052T3 (da) | 2010-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |