DE60228128D1 - Biokonjugat-nanopartikelsonden - Google Patents

Biokonjugat-nanopartikelsonden

Info

Publication number
DE60228128D1
DE60228128D1 DE60228128T DE60228128T DE60228128D1 DE 60228128 D1 DE60228128 D1 DE 60228128D1 DE 60228128 T DE60228128 T DE 60228128T DE 60228128 T DE60228128 T DE 60228128T DE 60228128 D1 DE60228128 D1 DE 60228128D1
Authority
DE
Germany
Prior art keywords
bioconjugate
probes
nanoparticle probes
nanoparticle
dithiothreitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228128T
Other languages
German (de)
English (en)
Inventor
Viswanadham Garimella
James J Storhoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosphere LLC
Original Assignee
Nanosphere LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere LLC filed Critical Nanosphere LLC
Application granted granted Critical
Publication of DE60228128D1 publication Critical patent/DE60228128D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
DE60228128T 2001-11-09 2002-11-08 Biokonjugat-nanopartikelsonden Expired - Lifetime DE60228128D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34823901P 2001-11-09 2001-11-09
PCT/US2002/035888 WO2003081202A2 (en) 2001-11-09 2002-11-08 Bioconjugate-nanoparticle probes

Publications (1)

Publication Number Publication Date
DE60228128D1 true DE60228128D1 (de) 2008-09-18

Family

ID=28454565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228128T Expired - Lifetime DE60228128D1 (de) 2001-11-09 2002-11-08 Biokonjugat-nanopartikelsonden

Country Status (8)

Country Link
US (1) US7186814B2 (US07186814-20070306-C00012.png)
EP (1) EP1466015B1 (US07186814-20070306-C00012.png)
JP (1) JP4220397B2 (US07186814-20070306-C00012.png)
AT (1) ATE403751T1 (US07186814-20070306-C00012.png)
AU (1) AU2002367817B2 (US07186814-20070306-C00012.png)
CA (1) CA2466656C (US07186814-20070306-C00012.png)
DE (1) DE60228128D1 (US07186814-20070306-C00012.png)
WO (1) WO2003081202A2 (US07186814-20070306-C00012.png)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6767702B2 (en) * 1996-07-29 2004-07-27 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
WO2002004681A2 (en) * 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002239726A1 (en) * 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
AU2005241112B2 (en) 2001-07-13 2009-07-30 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
US20060177852A1 (en) * 2001-12-12 2006-08-10 Do-Coop Technologies Ltd. Solid-fluid composition
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
CA2490413C (en) 2002-07-02 2011-08-30 Nanosphere, Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
US20050130174A1 (en) * 2003-02-27 2005-06-16 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7226636B2 (en) * 2003-07-31 2007-06-05 Los Alamos National Security, Llc Gold-coated nanoparticles for use in biotechnology applications
JP4207754B2 (ja) * 2003-10-31 2009-01-14 和光純薬工業株式会社 磁性体を用いた免疫学的測定方法
US7396677B2 (en) * 2003-11-07 2008-07-08 Nanosphere, Inc. Method of preparing nucleic acids for detection
US7906345B2 (en) 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
JP4557973B2 (ja) * 2004-03-31 2010-10-06 塩野義製薬株式会社 金属微粒子を用いた質量分析方法
US7462452B2 (en) * 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
WO2006028601A2 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant s. aureus from methicillin sensitive s. aureus in a mixed culture
US20060134694A1 (en) * 2004-12-22 2006-06-22 Intel Corporation Methods of protein profiling by thiolation
JP4791867B2 (ja) * 2005-03-31 2011-10-12 日立マクセル株式会社 貴金属コート磁性粒子を用いた被検物質の検出方法
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
WO2007024676A2 (en) * 2005-08-19 2007-03-01 Nanosphere, Inc. Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof
US20090004296A1 (en) * 2006-01-04 2009-01-01 Do-Coop Technologies Ltd. Antiseptic Compositions and Methods of Using Same
AU2007203961A1 (en) * 2006-01-04 2007-07-12 Do-Coop Technologies Ltd. Solid-fluid composition
US20090253613A1 (en) * 2006-01-04 2009-10-08 Do-Coop Technologies Ltd. Solid-Fluid Composition
WO2008091364A2 (en) * 2006-06-30 2008-07-31 Intel Corporation Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance
KR100828936B1 (ko) 2006-08-01 2008-05-20 김성천 단일가닥핵산 압타머와 금-나노입자를 이용한 생체분자분석방법
KR20090095674A (ko) * 2007-01-04 2009-09-09 두-쿱 테크놀로지스 리미티드 분석물의 검출
WO2008081456A2 (en) * 2007-01-04 2008-07-10 Do-Coop Technologies Ltd. Composition and method for enhancing cell growth and cell fusion
CN101678090B (zh) 2007-03-07 2012-04-11 乌第有限合伙公司 用于预防和治疗自身免疫病的组合物和方法
US8597959B2 (en) * 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
US20100209946A1 (en) * 2007-04-19 2010-08-19 Naiyong Jing Uses of water-dispersible silica nanoparticles for attaching biomolecules
US20090026075A1 (en) * 2007-07-26 2009-01-29 Agamatrix, Inc. Electrochemical Analyte Detection Apparatus and Method
US9863939B2 (en) 2007-09-20 2018-01-09 Magarray, Inc. Analyte detection with magnetic sensors
US20090185113A1 (en) * 2008-01-22 2009-07-23 Industrial Technology Research Institute Color Filter Module and Device of Having the Same
US9506919B2 (en) 2009-04-13 2016-11-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for detecting the presence of an analyte in a sample
CA2760774A1 (en) * 2009-05-05 2010-11-11 Altermune Technologies, Llc Chemically programmable immunity
US20100291541A1 (en) * 2009-05-14 2010-11-18 Evoy Stephane Bacteriophage immobilization for biosensors
US10101299B2 (en) 2010-03-12 2018-10-16 The Board Of Trustees Of The Leland Standford Junior University Magnetic sensor based quantitative binding kinetics analysis
PL2621523T3 (pl) 2010-09-29 2018-04-30 Uti Lp Sposoby leczenia choroby autoimmunologicznej z zastosowaniem biokompatybilnych bioabsorbowalnych nanosfer
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
US9851308B2 (en) * 2010-11-19 2017-12-26 Wisconsin Alumni Research Foundation (Warf) Visible detection of microorganisms
EP2643480A4 (en) * 2010-11-22 2014-05-14 Solulink Inc METHODS AND / OR USE OF OLIGONUCLEOTIDE CONJUGATES FOR TESTS AND DETECTIONS
WO2012122536A2 (en) 2011-03-09 2012-09-13 Magarray, Inc. Systems and methods for high-throughput detection of an analyte in a sample
US8946389B2 (en) 2011-04-25 2015-02-03 University Of Washington Compositions and methods for multiplex biomarker profiling
WO2013177046A1 (en) 2012-05-21 2013-11-28 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
US9982292B2 (en) 2012-09-28 2018-05-29 Src, Inc. Detecting chemical and biological agents using textile-based sensors
US9512468B2 (en) 2012-11-06 2016-12-06 Industrial Technology Research Institute Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto
EP2973769B1 (en) 2013-03-15 2020-02-12 Magarray, Inc. Magnetic tunnel junction sensors and methods for using the same
KR102325668B1 (ko) * 2013-10-23 2021-11-12 켐진스 코포레이션 고체 표면에 생체분자의 강한 고정용 디티올란 기능화된 뉴클레오시드 아미디트 및 지지체
KR101718867B1 (ko) * 2014-06-02 2017-03-22 한국과학기술연구원 생체적합성 형광 나노입자 및 이의 용도
CN104909463A (zh) * 2015-05-09 2015-09-16 浙江省农业科学院 一种核壳结构净水菌胶囊及其制备方法
CN104894097B (zh) * 2015-05-09 2018-11-06 浙江省农业科学院 一种长效净水菌胶囊及其制备方法
CN107636162B (zh) 2015-06-01 2021-12-10 加利福尼亚技术学院 用针对特定群体的抗原筛选t细胞的组合物和方法
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN113311047B (zh) * 2021-05-06 2022-06-21 复旦大学 一种纳米金颗粒修饰的伪mos生化分子传感器及其制备方法
US11795505B2 (en) 2022-03-10 2023-10-24 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4256834A (en) 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
US4713348A (en) 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US5288609A (en) * 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4868104A (en) 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US5137827A (en) * 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5360895A (en) * 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
US4853335A (en) 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
GB8800702D0 (en) 1988-01-13 1988-02-10 Nycomed As Test method & reagent kit therefor
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
US5460831A (en) 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
GB9019512D0 (en) 1990-09-06 1990-10-24 Ici Plc Assay method
US5665582A (en) 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
JPH06510363A (ja) * 1990-10-29 1994-11-17 ディカルブ　プラント　ジェネティクス 磁気性粒子を使用する生物学的材料の単離
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
EP0613585A4 (en) 1991-11-22 1995-06-21 Univ California SEMICONDUCTOR NANOCRYSTALS COVALENTLY LINKED TO SOLID INORGANIC SURFACES USING SELF-ASSEMBLED MONO-LAYERS.
US5225064A (en) 1992-01-15 1993-07-06 Enzyme Technology Research Group, Inc. Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination
GB9212164D0 (en) 1992-06-09 1992-07-22 Medical Res Council Preparation of nucleic acids
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5637508A (en) * 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
US5384265A (en) * 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
DK0702728T3 (da) 1993-06-09 1998-06-02 Gamera Bioscience Corp Magnetisk cyklusreaktion
EP0630974A3 (en) 1993-06-25 1995-11-15 Clinical Diagnostic Syst Method and test kit for the detection of inorganic orthophosphate in the amplification of target nucleic acids.
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JPH07227299A (ja) 1994-02-14 1995-08-29 Kyoto Daiichi Kagaku:Kk Ｄｎａの特定塩基配列の検出方法及びその装置
US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US6121425A (en) * 1994-07-29 2000-09-19 Nanoprobes, Inc. Metal-lipid molecules
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5609907A (en) 1995-02-09 1997-03-11 The Penn State Research Foundation Self-assembled metal colloid monolayers
US6025202A (en) 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
CN1262667C (zh) * 1996-04-25 2006-07-05 詹尼康科学公司 利用颗粒标记物检测分析物
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6767702B2 (en) 1996-07-29 2004-07-27 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
AU4043497A (en) 1996-07-29 1998-02-20 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO1998010289A1 (en) 1996-09-04 1998-03-12 The Penn State Research Foundation Self-assembled metal colloid monolayers
DE59707744D1 (de) 1996-10-23 2002-08-22 Sueddeutsche Kalkstickstoff Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten
US5830986A (en) 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6149868A (en) 1997-10-28 2000-11-21 The Penn State Research Foundation Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches
AUPP004497A0 (en) 1997-10-28 1997-11-20 University Of Melbourne, The Stabilized particles
WO1999023258A1 (en) 1997-10-31 1999-05-14 Gen-Probe Incorporated Methods of nucleic acid detection
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5972615A (en) * 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
IL126776A (en) 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
WO2000033079A1 (en) 1998-11-30 2000-06-08 Nanosphere, Inc. Nanoparticles with polymer shells
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
EP1198591B1 (en) 1999-06-25 2011-03-16 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
JP2003506919A (ja) 1999-08-03 2003-02-18 ポリコム・インコーポレイテッド 無線通信システムにおける保全データ転送のためのシステムおよび方法
JP2004515208A (ja) 2000-03-28 2004-05-27 ナノスフェアー インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
US6927033B2 (en) 2000-05-11 2005-08-09 Toudai Tlo, Ltd. Polymer composition for forming surface of biosensor
WO2002004681A2 (en) 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
EP1362121A2 (en) 2000-08-11 2003-11-19 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
JP2004534721A (ja) 2000-10-31 2004-11-18 ピーアール ファーマシューティカルズ，インク． 生理活性分子の向上した送達のための方法及び組成物
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
EP1356109A2 (en) 2000-12-08 2003-10-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6958216B2 (en) * 2001-01-10 2005-10-25 The Trustees Of Boston College DNA-bridged carbon nanotube arrays
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002365247B2 (en) 2001-08-03 2006-06-08 Nanosphere, Inc. Nanoparticle imaging system and method
US20050059030A1 (en) 2002-12-12 2005-03-17 Nanosphere, Inc. Direct SNP detection with unamplified DNA

Also Published As

Publication number Publication date
JP4220397B2 (ja) 2009-02-04
AU2002367817B2 (en) 2008-05-29
EP1466015A2 (en) 2004-10-13
AU2002367817A1 (en) 2003-10-08
WO2003081202A3 (en) 2004-07-22
CA2466656A1 (en) 2003-10-02
EP1466015A4 (en) 2007-02-28
JP2005519627A (ja) 2005-07-07
US20030143598A1 (en) 2003-07-31
CA2466656C (en) 2013-07-02
EP1466015B1 (en) 2008-08-06
WO2003081202A2 (en) 2003-10-02
US7186814B2 (en) 2007-03-06
ATE403751T1 (de) 2008-08-15

Similar Documents

Publication Publication Date Title
DE60228128D1 (de) Biokonjugat-nanopartikelsonden
ATE530911T1 (de) Bindungsproteine als biosensoren
Jones et al. Analogues of thiolactomycin as potential antimalarial agents
PT911333E (pt) Derivados de pirazolo¬4,3-d|pirimidina e composicoes farmaceuticas que os contenham
ATE330038T1 (de) Nukleinsäure-biosensor
KR100711046B1 (ko) 대장암에 대한 마커로서의 니코틴아미드ｎ―메틸트랜스퍼라아제의 용도
NO20080629L (no) Tiazolderivater som AMPK-aktiverere
WO2008054600A3 (en) Compositions and methods for biodetection by nucleic acid-templated chemistry
WO2004051224A3 (en) Multiplexed methylation detection methods
ATE384119T1 (de) Isoprenoidproduktion
BR0212968A (pt) Composição farmacêutica, composto, e, método para tratar ou prevenir condições mediadas pelo ccr2, mcp-1 ou pela interação destes
NO20042926L (no) Indolinonderivater nyttige sorn proteinkinaseinhibitorer
CY1105247T1 (el) Υποκατεστημενα παραγωγα c- κυκλοεξυλομεθυλαμινης
MXPA04000210A (es) Conjugados quelantes mejorados.
Chen et al. Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases
DE69021639T2 (de) Disäuren von Diarylstyrylchinolin.
DE69920923D1 (de) Anthranilsäurederivate
Chen et al. Target-protecting dumbbell molecular probe against exonucleases digestion for sensitive detection of ATP and streptavidin
Heal et al. Getting a chemical handle on protein post-translational modification
ATE498600T1 (de) Inden derivate als pharmazeutika
ATE330031T1 (de) Reversibel inhibierende sonden
DE60113811D1 (de) NACHWEIS DER BINDUNG VON Ladungsträgern mittels PH- ODER POTENTiaL-SENSITIVEr SONDEN
BR9916679A (pt) Método e aparelho para calibrar medição de sensor analógico
EP1265073A3 (en) Methods for determining plasma free drug concentration
ATE500505T1 (de) Enzymhemmungsimmunverfahren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition