DE60224383D1 - Verfahren zum nachweis in hefe für mittels die proteinfaltung beeinflussen - Google Patents
Verfahren zum nachweis in hefe für mittels die proteinfaltung beeinflussenInfo
- Publication number
- DE60224383D1 DE60224383D1 DE60224383T DE60224383T DE60224383D1 DE 60224383 D1 DE60224383 D1 DE 60224383D1 DE 60224383 T DE60224383 T DE 60224383T DE 60224383 T DE60224383 T DE 60224383T DE 60224383 D1 DE60224383 D1 DE 60224383D1
- Authority
- DE
- Germany
- Prior art keywords
- disease
- yeast
- protein
- procedure
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26915701P | 2001-02-15 | 2001-02-15 | |
US269157P | 2001-02-15 | ||
PCT/US2002/004632 WO2002065136A2 (en) | 2001-02-15 | 2002-02-15 | Yeast screens for agents affecting protein folding |
EP02718994A EP1392849B2 (de) | 2001-02-15 | 2002-02-15 | Verfahren zum nachweis in hefe für mittel die proteinfaltung beeinflussen |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60224383D1 true DE60224383D1 (de) | 2008-02-14 |
DE60224383T2 DE60224383T2 (de) | 2009-01-08 |
DE60224383T3 DE60224383T3 (de) | 2012-06-28 |
Family
ID=23026039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60224383T Expired - Lifetime DE60224383T3 (de) | 2001-02-15 | 2002-02-15 | Verfahren zum nachweis in hefe für mittel die proteinfaltung beeinflussen |
Country Status (8)
Country | Link |
---|---|
US (7) | US7045290B2 (de) |
EP (2) | EP1392849B2 (de) |
JP (2) | JP4344138B2 (de) |
AT (2) | ATE382704T1 (de) |
AU (3) | AU2002250102B2 (de) |
CA (1) | CA2438661C (de) |
DE (1) | DE60224383T3 (de) |
WO (1) | WO2002065136A2 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799535B1 (en) | 1997-12-09 | 2010-09-21 | Arch Development Corporation | Methods for identifying factors that control the folding of amyloid proteins of diverse origin |
DE60224383T3 (de) * | 2001-02-15 | 2012-06-28 | The University Of Chicago | Verfahren zum nachweis in hefe für mittel die proteinfaltung beeinflussen |
US8183350B2 (en) | 2002-05-04 | 2012-05-22 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
EP1575510A4 (de) * | 2002-08-07 | 2007-12-26 | Univ Delaware | Zusammensetzungen und verfahren zur behandlung von krankheiten mit protein-fehlanordnung und aggregation |
FR2846009B1 (fr) * | 2002-10-18 | 2007-10-12 | Centre Nat Rech Scient | Criblage de molecules a activite anti-prion:kits, methodes et molecules criblees |
FR2846008B1 (fr) * | 2002-10-18 | 2006-06-02 | Centre Nat Rech Scient | Criblage de molecules a activite anti-prion:kits, methodes et molecules criblees |
JP2007521792A (ja) * | 2003-04-16 | 2007-08-09 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | 異常に切断されたタンパク質を異所性発現する酵母、およびこの用途 |
US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
CA2525784C (en) | 2003-05-16 | 2019-04-09 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of cns |
DK1644505T3 (da) * | 2003-07-11 | 2008-08-18 | Remynd Nv | Gærmodel for amyloidogen proteintoksicitet |
US7452670B2 (en) | 2003-12-04 | 2008-11-18 | University Of Washington | Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast |
US8192986B2 (en) * | 2004-05-05 | 2012-06-05 | Whitehead Institute For Biomedical Research | Compositions and methods for treatment of protein misfolding diseases |
CA2566731C (en) | 2004-05-18 | 2012-07-24 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
CA2568644C (en) * | 2004-06-03 | 2015-11-24 | Phylogica Limited | Peptide modulators of cellular phenotype and bi-nucleic acid fragment library |
NZ584773A (en) | 2004-09-17 | 2012-07-27 | Whitehead Biomedical Inst | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity |
US7504227B2 (en) * | 2004-10-20 | 2009-03-17 | University Of Washington | Drug targets for the treatment of neurodegenerative disorders |
US7618793B2 (en) * | 2004-10-20 | 2009-11-17 | The Regents Of The University Of Washington | Identifying agents for decreasing cellular toxicity associated with huntingin polypeptide |
AU2005323173A1 (en) * | 2004-12-01 | 2006-07-13 | The Curators Of The University Of Missouri | Modulator of alpha-synuclein toxicity |
EP1888095A4 (de) | 2005-05-13 | 2009-08-26 | Whitehead Biomedical Inst | Modulatoren der alpha-synuclein-toxizität |
US7368258B1 (en) * | 2005-06-06 | 2008-05-06 | University Of Maryland, Baltimore County | Devices and methods for profiling enzyme substrates |
US7485295B2 (en) | 2005-09-26 | 2009-02-03 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
EP2007373A4 (de) * | 2006-03-29 | 2012-12-19 | Foldrx Pharmaceuticals Inc | Hemmung der alpha-synuclein-toxizität |
GB0610792D0 (en) * | 2006-06-02 | 2006-07-12 | Remynd Nv | Methods and tools for the screening of factors affecting protein misfolding |
US7722864B2 (en) | 2006-10-10 | 2010-05-25 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
US8975063B2 (en) | 2006-10-19 | 2015-03-10 | California Institute Of Technology | Compositions and methods for producing benzylisoquinoline alkaloids |
US8323952B2 (en) * | 2007-12-13 | 2012-12-04 | Archer Daniels Midland Company | Alcoholic xylose fermentation at high temperatures by the thermotolerant yeast Hansenula polymorpha |
WO2009086306A1 (en) | 2007-12-21 | 2009-07-09 | Whitehead Institute For Biomedical Research | Modulators of alpha-synuclein toxicity |
EP2262895B1 (de) | 2008-02-15 | 2013-08-14 | Whitehead Institute For Biomedical Research | Hefezellen mit expression des tar-dna-bindungsproteins 43 und verwendungen dafür |
ES2418459B1 (es) * | 2008-10-09 | 2014-08-12 | Universitat Autònoma De Barcelona | Relacionando agregación proteica con supervivencia de levadura |
US8865411B2 (en) | 2009-03-26 | 2014-10-21 | National Institutes Of Health (Nih) | Methods of identifying modulators of TDP-43 mediated cellular toxicity |
EP2524040B1 (de) * | 2010-01-12 | 2017-03-15 | The Whitehead Institute for Biomedical Research | Hefezellen zur expression von amyloid-beta und verwendungen davon |
CN101858910B (zh) * | 2010-03-25 | 2013-03-27 | 辽宁大学 | 一种在蛋白质水平精确定量检测抗朊病毒药物作用效果的方法 |
WO2013179144A2 (en) * | 2012-06-01 | 2013-12-05 | Oxalys Pharmaceuticals | Chemical suppressors of neurotoxicity in synucleinopathic diseases |
US10642376B2 (en) | 2012-11-28 | 2020-05-05 | Intel Corporation | Multi-function stylus with sensor controller |
EP2970999A2 (de) | 2013-03-15 | 2016-01-20 | The Board Of Trustees Of The University Of the Leland Stanford Junior University | Benzylisochinolin-alkaloide (bia) produzierende mikroben sowie verfahren zur herstellung und verwendung davon |
US11047848B2 (en) | 2013-03-15 | 2021-06-29 | Whitehead Institute For Biomedical Research | Cellular discovery platform for neurodegenerative diseases |
CN112410379A (zh) | 2013-11-04 | 2021-02-26 | 小利兰·斯坦福大学托管委员会 | 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法 |
CH709681A1 (de) | 2014-05-21 | 2015-11-30 | Explo Engineering Ag | Pulsdetonationsantrieb. |
EP3155003B9 (de) | 2014-06-13 | 2020-12-30 | Whitehead Institute for Biomedical Research | Amyloid-beta-expression-konstrukte und verwendungen davon |
JP2017522886A (ja) * | 2014-07-29 | 2017-08-17 | ニューリミューン ホールディング エイジー | ヒト由来抗ハンチンチン(htt)抗体及びその使用 |
JP6824158B2 (ja) * | 2014-09-12 | 2021-02-03 | ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ | アポリポタンパク質eを発現する細胞及びその使用 |
CN107614688B (zh) | 2015-05-04 | 2023-02-28 | 小利兰·斯坦福大学托管委员会 | 产生苄基异喹啉生物碱(bia)前体的微生物及其制备和使用方法 |
GB2555044B (en) | 2015-05-08 | 2021-03-17 | Univ Leland Stanford Junior | Methods of producing epimerases and benzylisoquinoline alkaloids |
EP3423158B1 (de) * | 2016-02-24 | 2023-11-15 | The Rockefeller University | Embryonalzellbasierte therapeutische kandidatenscreening-systeme, modelle für die huntington-krankheit und verwendungen davon |
MX2019009117A (es) | 2017-02-17 | 2019-09-13 | Bristol Myers Squibb Co | Anticuerpos anti alfa-sinucleina y usos de los mismos. |
WO2019028390A1 (en) | 2017-08-03 | 2019-02-07 | Antheia, Inc. | ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS |
US10550550B2 (en) * | 2017-09-13 | 2020-02-04 | Dominic P. Ismert | Modular two-part sillcock |
US10649550B2 (en) | 2018-06-26 | 2020-05-12 | Intel Corporation | Predictive detection of user intent for stylus use |
WO2023284782A1 (zh) * | 2021-07-14 | 2023-01-19 | 复旦大学 | 筛选用于治疗或预防mHTT相关的神经退行性疾病的化合物的方法,靶蛋白,以及化合物 |
WO2023137286A1 (en) * | 2022-01-12 | 2023-07-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and related aspects of quantifying protein stability and misfolding |
CN114990049B (zh) * | 2022-04-26 | 2024-01-16 | 鼎康(武汉)生物医药有限公司 | 一种同时调节细胞表达产物的糖型和电荷异质性的方法 |
DE202022107272U1 (de) | 2022-12-28 | 2023-01-30 | Centurion University of Technology and Management | Ein System zur Analyse der Infektion mit Pseudomonas Syringae durch gezielte Ansprache von Cochaperonen, die eine J-Domäne enthalten |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4682195A (en) | 1985-09-30 | 1987-07-21 | General Electric Company | Insulated gate device with configured emitter contact pad |
EP0266032A1 (de) | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modifiziertes fibrinolytisches Enzym |
US5547841A (en) * | 1987-10-08 | 1996-08-20 | The Mclean Hospital Corporation | In vitro method for screening for drugs that inhibit production or degradation of human A4-amyloid |
JPH05502368A (ja) * | 1989-09-18 | 1993-04-28 | サイオス ノバ インコーポレイテッド | アミロイド沈着物の測定法および試薬 |
GB8921791D0 (en) | 1989-09-27 | 1989-11-08 | Imp Cancer Res Tech | Disease gene |
WO1993003369A1 (en) | 1991-08-01 | 1993-02-18 | Voorheis Paul H | Diagnostic method for alzheimer's disease |
DE4204650C1 (de) | 1992-02-15 | 1993-07-08 | Hoffmeister, Helmut, Dr., 4400 Muenster, De | |
TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
KR940021073A (ko) * | 1993-03-02 | 1994-10-17 | 미야베 요시가즈 | 알쯔하이머병의 예방 또는 치료제, 그 스크리닝 방법 및 인간 유래의 타우 단백질 키나아제 i |
CA2116280A1 (en) * | 1993-03-05 | 1994-09-06 | Marcy E. Macdonald | Huntingtin dna, protein and uses thereof |
US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
CA2157774A1 (en) | 1993-04-07 | 1994-10-13 | Christopher John Marshall | Methods for screening of substances for therapeutic activity and yeast for use therein |
GB9316727D0 (en) * | 1993-08-12 | 1993-09-29 | Inst Of Psychiatry | Models of alzheimers's disease |
US5705629A (en) | 1995-10-20 | 1998-01-06 | Hybridon, Inc. | Methods for H-phosphonate synthesis of mono- and oligonucleotides |
US6093549A (en) * | 1995-11-09 | 2000-07-25 | The Johns Hopkins University | Huntingtin-associated protein-related assays |
US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
WO1999006545A2 (en) | 1997-08-01 | 1999-02-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation |
US5952217A (en) * | 1997-09-23 | 1999-09-14 | Bristol-Myers Squibb Company | Recombinant yeast cell and assay using same |
US7799535B1 (en) * | 1997-12-09 | 2010-09-21 | Arch Development Corporation | Methods for identifying factors that control the folding of amyloid proteins of diverse origin |
US20010006793A1 (en) * | 1998-03-20 | 2001-07-05 | Mary-Ann Bjornsti | Modulators of eukaryotic caspases |
WO1999062548A1 (en) | 1998-06-01 | 1999-12-09 | Advanced Research And Technology Institute | Methods and compositions for diagnosing tauopathies |
NZ515956A (en) | 1999-07-02 | 2004-04-30 | Janssen Pharmaceutica Nv | Transgenic animals as models for neurodegenerative disease |
EP1204674A4 (de) * | 1999-07-27 | 2005-06-01 | Abgenix Inc | Methoden und verbindungen zur verhinderung von polypeptid-ansammlungen im zusammenhang mit neurologischen störungen |
US6420122B1 (en) * | 1999-09-27 | 2002-07-16 | Massachusetts Institute Of Technology | Methods of screening for agents that inhibit aggregation of polypeptides |
MXPA02007796A (es) * | 2000-02-21 | 2003-12-08 | Pharmexa As | Metodo novedoso para la disminucion de cuerpos amiloides. |
IT1317922B1 (it) | 2000-10-24 | 2003-07-15 | S I S S A Scuola Internaz Supe | Metodo per identificare in vivo epitopi intracellulari. |
DE60224383T3 (de) * | 2001-02-15 | 2012-06-28 | The University Of Chicago | Verfahren zum nachweis in hefe für mittel die proteinfaltung beeinflussen |
GB0104685D0 (en) * | 2001-02-26 | 2001-04-11 | Leuven K U Res & Dev | Tau-opathy model |
US20030022243A1 (en) | 2001-06-20 | 2003-01-30 | Les Kondejewski | Protein aggregation assays and uses thereof |
DK1644505T3 (da) | 2003-07-11 | 2008-08-18 | Remynd Nv | Gærmodel for amyloidogen proteintoksicitet |
-
2002
- 2002-02-15 DE DE60224383T patent/DE60224383T3/de not_active Expired - Lifetime
- 2002-02-15 US US10/077,584 patent/US7045290B2/en not_active Expired - Lifetime
- 2002-02-15 CA CA2438661A patent/CA2438661C/en not_active Expired - Lifetime
- 2002-02-15 AT AT02718994T patent/ATE382704T1/de not_active IP Right Cessation
- 2002-02-15 JP JP2002564603A patent/JP4344138B2/ja not_active Expired - Lifetime
- 2002-02-15 AU AU2002250102A patent/AU2002250102B2/en not_active Expired
- 2002-02-15 EP EP02718994A patent/EP1392849B2/de not_active Expired - Lifetime
- 2002-02-15 WO PCT/US2002/004632 patent/WO2002065136A2/en active IP Right Grant
- 2002-02-15 EP EP10180773A patent/EP2319936A3/de not_active Withdrawn
- 2002-02-15 AT AT06024213T patent/ATE532874T1/de active
-
2006
- 2006-02-27 US US11/363,869 patent/US20060147902A1/en not_active Abandoned
- 2006-02-27 US US11/363,870 patent/US8039209B2/en not_active Expired - Fee Related
-
2007
- 2007-10-10 AU AU2007221933A patent/AU2007221933B2/en not_active Ceased
-
2008
- 2008-04-17 JP JP2008108214A patent/JP5152977B2/ja not_active Expired - Lifetime
-
2011
- 2011-02-22 AU AU2011200744A patent/AU2011200744B2/en not_active Expired
- 2011-04-20 US US13/090,653 patent/US20110300533A1/en not_active Abandoned
-
2012
- 2012-05-02 US US13/462,478 patent/US20130005608A1/en not_active Abandoned
-
2013
- 2013-12-13 US US14/105,500 patent/US9518284B2/en not_active Expired - Lifetime
-
2016
- 2016-11-08 US US15/345,739 patent/US20170306386A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8039209B2 (en) | 2011-10-18 |
US20130005608A1 (en) | 2013-01-03 |
ATE532874T1 (de) | 2011-11-15 |
AU2007221933A1 (en) | 2007-11-01 |
DE60224383T2 (de) | 2009-01-08 |
ATE382704T1 (de) | 2008-01-15 |
US20060147902A1 (en) | 2006-07-06 |
EP2319936A2 (de) | 2011-05-11 |
US9518284B2 (en) | 2016-12-13 |
EP1392849A2 (de) | 2004-03-03 |
JP2004537973A (ja) | 2004-12-24 |
WO2002065136A2 (en) | 2002-08-22 |
AU2007221933B2 (en) | 2010-12-16 |
EP2319936A3 (de) | 2012-10-17 |
US20030073610A1 (en) | 2003-04-17 |
AU2011200744A1 (en) | 2011-03-17 |
US20110300533A1 (en) | 2011-12-08 |
US20170306386A1 (en) | 2017-10-26 |
WO2002065136A3 (en) | 2003-12-11 |
CA2438661A1 (en) | 2002-08-22 |
JP4344138B2 (ja) | 2009-10-14 |
US20140273074A1 (en) | 2014-09-18 |
EP1392849B1 (de) | 2008-01-02 |
DE60224383T3 (de) | 2012-06-28 |
CA2438661C (en) | 2011-05-31 |
JP5152977B2 (ja) | 2013-02-27 |
US20060141449A1 (en) | 2006-06-29 |
AU2011200744B2 (en) | 2013-04-04 |
US7045290B2 (en) | 2006-05-16 |
AU2002250102B2 (en) | 2007-07-12 |
EP1392849B2 (de) | 2012-01-18 |
JP2008259509A (ja) | 2008-10-30 |
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