DE60223511T2 - Neurotrophe faktoren - Google Patents

Neurotrophe faktoren Download PDF

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Publication number
DE60223511T2
DE60223511T2 DE60223511T DE60223511T DE60223511T2 DE 60223511 T2 DE60223511 T2 DE 60223511T2 DE 60223511 T DE60223511 T DE 60223511T DE 60223511 T DE60223511 T DE 60223511T DE 60223511 T2 DE60223511 T2 DE 60223511T2
Authority
DE
Germany
Prior art keywords
seq
neublastin
polypeptide
cells
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223511T
Other languages
German (de)
English (en)
Other versions
DE60223511D1 (de
Inventor
Dinah Wen Cambridge SAH
Teit E. Johansen
Anthony Revere ROSSOMANDO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NsGene AS
Biogen Inc
Biogen MA Inc
Original Assignee
NsGene AS
Biogen Idec Inc
Biogen Idec MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NsGene AS, Biogen Idec Inc, Biogen Idec MA Inc filed Critical NsGene AS
Publication of DE60223511D1 publication Critical patent/DE60223511D1/de
Application granted granted Critical
Publication of DE60223511T2 publication Critical patent/DE60223511T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/4756Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DE60223511T 2001-03-12 2002-03-12 Neurotrophe faktoren Expired - Lifetime DE60223511T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/804,615 US20020055467A1 (en) 1998-07-06 2001-03-12 Novel neurotrophic factors
US804615 2001-03-12
PCT/EP2002/002691 WO2002072826A2 (en) 2001-03-12 2002-03-12 Neurotrophic factors

Publications (2)

Publication Number Publication Date
DE60223511D1 DE60223511D1 (de) 2007-12-27
DE60223511T2 true DE60223511T2 (de) 2008-10-23

Family

ID=25189406

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223511T Expired - Lifetime DE60223511T2 (de) 2001-03-12 2002-03-12 Neurotrophe faktoren

Country Status (15)

Country Link
US (1) US20020055467A1 (enExample)
EP (2) EP1930439B1 (enExample)
JP (2) JP3738008B2 (enExample)
CN (1) CN1268744C (enExample)
AT (2) ATE378353T1 (enExample)
AU (1) AU2002240943B2 (enExample)
CA (1) CA2440767C (enExample)
CY (1) CY1111750T1 (enExample)
DE (1) DE60223511T2 (enExample)
DK (2) DK1373503T3 (enExample)
ES (2) ES2296899T3 (enExample)
NZ (1) NZ528790A (enExample)
PT (2) PT1373503E (enExample)
SI (2) SI1930439T1 (enExample)
WO (1) WO2002072826A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593133B1 (en) * 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
WO2000004050A2 (en) * 1998-07-14 2000-01-27 Janssen Pharmaceutica N.V. Neurotrophic growth factor
MXPA03005721A (es) * 2000-12-22 2004-04-21 Genentech Inc Uso novedoso de artemina, un miembro de la familia de ligandos gdnf.
US7442370B2 (en) * 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
CA2442159C (en) * 2001-03-28 2011-08-23 Biogen, Inc. Treatment using neublastin polypeptides
JP2005516949A (ja) * 2001-12-19 2005-06-09 リジュン・ワン Gdnfの骨格筋へのアデノ随伴ウイルス媒介性のデリバリー
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Jx日鉱日石エネルギー株式会社 潤滑油組成物
EP2301960A3 (en) * 2003-01-31 2011-08-03 Biogen Idec MA Inc. Polymer conjugates of mutated neublastin
NZ543365A (en) 2003-04-18 2009-02-28 Biogen Idec Inc Polymer-conjugated glycosylated neublastin
DE602004019524D1 (de) 2003-06-10 2009-04-02 Nsgene As Verbesserte sezernierung von neublastin
US7598059B2 (en) * 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
WO2005039643A2 (en) 2003-10-20 2005-05-06 Nsgene A/S In vivo gene therapy of parkinson's disease
DE602005022082D1 (de) * 2004-08-19 2010-08-12 Biogen Idec Inc Rückfaltung von proteinen der transforming-growth-factor-beta-familie
EP1786454B1 (en) * 2004-08-19 2010-07-21 Biogen Idec MA Inc. Neublastin variants
EP1937295A2 (en) * 2005-10-11 2008-07-02 NS Gene A/S Treatment of retinopathies using gfr 3 agonists
TWI501774B (zh) * 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
ES2450065T3 (es) * 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
US8329655B2 (en) 2007-05-01 2012-12-11 Biogen Idec Ma Inc. Methods for increasing vascularization
US20110135648A1 (en) * 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
US20100247437A1 (en) * 2007-10-01 2010-09-30 Vgx Pharmaceuticals, Llc Materials and methods for the delivery of biomolecules to cells of an organ
CA2813013C (en) * 2010-10-01 2019-10-22 Nsgene A/S Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain
JP7235230B2 (ja) * 2018-05-17 2023-03-08 ヘリックスミス カンパニー, リミテッド 化学療法-誘発末梢神経病症と関連した神経病症性痛みの治療
CN117279657A (zh) 2021-05-18 2023-12-22 日本株式会社Ltt生物医药 用于治疗或预防伴随抗癌剂给药的障碍的医药组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
KR100587556B1 (ko) 1996-05-08 2006-06-08 바이오겐 아이덱 엠에이 인코포레이티드 신경 및 신장 증식을 자극하기 위한 RET리간드(RetL)
US6593133B1 (en) * 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US6284540B1 (en) * 1998-09-29 2001-09-04 Washington University Artemin, a novel neurotrophic factor
JP2002531128A (ja) * 1998-12-09 2002-09-24 アムジエン・インコーポレーテツド 神経栄養因子grnf4
PT1185648E (pt) * 1999-06-22 2007-06-29 Genentech Inc Métodos e composições para a inibição do crescimento de células neoplásicas.

Also Published As

Publication number Publication date
CN1268744C (zh) 2006-08-09
ATE378353T1 (de) 2007-11-15
ES2296899T3 (es) 2008-05-01
JP2005198656A (ja) 2005-07-28
CA2440767C (en) 2012-05-29
ES2366610T3 (es) 2011-10-21
PT1930439E (pt) 2011-07-25
ATE509103T1 (de) 2011-05-15
CN1509333A (zh) 2004-06-30
AU2002240943A2 (en) 2002-09-24
EP1373503A2 (en) 2004-01-02
NZ528790A (en) 2004-06-25
HK1120556A1 (en) 2009-04-03
DE60223511D1 (de) 2007-12-27
DK1373503T3 (da) 2008-03-25
EP1930439B1 (en) 2011-05-11
AU2002240943B2 (en) 2007-05-10
JP2004531242A (ja) 2004-10-14
EP1930439A1 (en) 2008-06-11
JP3738008B2 (ja) 2006-01-25
WO2002072826A3 (en) 2003-04-10
PT1373503E (pt) 2008-02-26
WO2002072826A2 (en) 2002-09-19
DK1930439T3 (da) 2011-08-29
SI1373503T1 (sl) 2008-04-30
CY1111750T1 (el) 2015-10-07
EP1373503B1 (en) 2007-11-14
US20020055467A1 (en) 2002-05-09
CA2440767A1 (en) 2002-09-19
SI1930439T1 (sl) 2011-09-30

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