DE60217328D1 - Verfahren zur analyse von proteinproben - Google Patents

Verfahren zur analyse von proteinproben

Info

Publication number
DE60217328D1
DE60217328D1 DE60217328T DE60217328T DE60217328D1 DE 60217328 D1 DE60217328 D1 DE 60217328D1 DE 60217328 T DE60217328 T DE 60217328T DE 60217328 T DE60217328 T DE 60217328T DE 60217328 D1 DE60217328 D1 DE 60217328D1
Authority
DE
Germany
Prior art keywords
proteins
isotopically
labeled
samples
quantitative analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60217328T
Other languages
English (en)
Other versions
DE60217328T2 (de
Inventor
C Parker
K Nadler
J Vella
Yulin Huang
H Aeberesold
B Smolka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute for Systems Biology
Applied Biosystems LLC
Original Assignee
PerSeptive Biosystems Inc
Institute for Systems Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PerSeptive Biosystems Inc, Institute for Systems Biology filed Critical PerSeptive Biosystems Inc
Application granted granted Critical
Publication of DE60217328D1 publication Critical patent/DE60217328D1/de
Publication of DE60217328T2 publication Critical patent/DE60217328T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/964—Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DE60217328T 2001-05-08 2002-05-07 Verfahren zur analyse von proteinproben Expired - Lifetime DE60217328T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/851,058 US7045296B2 (en) 2001-05-08 2001-05-08 Process for analyzing protein samples
US851058 2001-05-08
PCT/US2002/014369 WO2002090929A2 (en) 2001-05-08 2002-05-07 Process for analyzing protein samples

Publications (2)

Publication Number Publication Date
DE60217328D1 true DE60217328D1 (de) 2007-02-15
DE60217328T2 DE60217328T2 (de) 2007-07-19

Family

ID=25309855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60217328T Expired - Lifetime DE60217328T2 (de) 2001-05-08 2002-05-07 Verfahren zur analyse von proteinproben

Country Status (7)

Country Link
US (1) US7045296B2 (de)
EP (1) EP1392848B1 (de)
JP (1) JP4188701B2 (de)
AT (1) ATE350666T1 (de)
AU (1) AU2002340828A1 (de)
DE (1) DE60217328T2 (de)
WO (1) WO2002090929A2 (de)

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AU2002341862C1 (en) * 2001-09-27 2009-01-29 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
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DE60325847D1 (de) * 2002-03-11 2009-03-05 Caprotec Bioanalytics Gmbh Verbindungen und verfahren für die analyse des proteoms
US7166441B2 (en) * 2002-03-12 2007-01-23 Perseptive Biosystems Inc. Method and apparatus for the identification and quantification of biomolecules
WO2003102542A2 (en) * 2002-05-31 2003-12-11 Ciphergen Biosystems, Inc. Comparative proteomics of progressor and nonprogressor populations
US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
CA2658334C (en) 2003-01-16 2012-07-10 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
CA2488584C (en) * 2003-01-30 2011-10-11 Applera Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
WO2004086281A1 (en) * 2003-03-25 2004-10-07 Institut Suisse De Bioinformatique Method for comparing proteomes
US7202473B2 (en) * 2003-04-10 2007-04-10 Micromass Uk Limited Mass spectrometer
EP1627083A2 (de) * 2003-05-07 2006-02-22 Agilent Technologies, Inc. Systeme und verfahren zur bestimmung der zelltypzusammensetzung von gemischten zellpopulationen unter verwendung von genexpressions-signaturen
US7307169B2 (en) * 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US7355045B2 (en) * 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US8012764B2 (en) * 2004-04-30 2011-09-06 Micromass Uk Limited Mass spectrometer
GB0409676D0 (en) * 2004-04-30 2004-06-02 Micromass Ltd Mass spectrometer
CA2567459A1 (en) * 2004-05-19 2005-12-01 Applera Corporation Expression quantification using mass spectrometry
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
JP2006078192A (ja) * 2004-09-07 2006-03-23 Shimadzu Corp 生体高分子の質量分析法
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
JP4563764B2 (ja) * 2004-10-01 2010-10-13 丸善製薬株式会社 ペプチドの定量方法
AU2006210551A1 (en) * 2005-02-03 2006-08-10 Perkinelmer Las, Inc. Ultra-sensitive detection systems using multidimension signals
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US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
JP4051400B2 (ja) * 2005-05-31 2008-02-20 株式会社Ｊｃｌバイオアッセイ プロテオーム網羅的解析における特異的蛋白質のスクリーニング方法
JP5011283B2 (ja) * 2005-06-03 2012-08-29 ウオーターズ・テクノロジーズ・コーポレイシヨン 化学分析のためのポリペプチド関連情報のカタログの発生および使用
CA2625781C (en) * 2005-10-13 2014-09-02 Applera Corporation Methods for the development of a biomolecule assay
US7901942B2 (en) 2005-11-08 2011-03-08 Tohoku University Method of quantifying membrane protein by mass spectrometry using peptide selection criteria
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
EP1916526A1 (de) * 2006-10-26 2008-04-30 Koninklijke Philips Electronics N.V. Verfahren zur Diagnose und therapeutischen Targetfindung durch Kombination von Isotopen- und Isobarenmarkern
KR100805777B1 (ko) * 2007-02-22 2008-02-21 한국기초과학지원연구원 질량 스펙트럼 데이터 및 １차원 젤에서의 밴드 위치분석을 포함하는 단백질 수식화 분석 시스템 및 이를이용한 단백질 수식화 분석 방법
US7880140B2 (en) * 2007-05-02 2011-02-01 Dh Technologies Development Pte. Ltd Multipole mass filter having improved mass resolution
US7820963B2 (en) 2007-08-06 2010-10-26 Metabolic Alayses, Inc. Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US8536520B2 (en) * 2007-08-06 2013-09-17 Iroa Technologies Llc Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US8969251B2 (en) * 2007-10-02 2015-03-03 Methabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
ES2456266T3 (es) * 2007-10-02 2014-04-21 Iroa Technologies Llc Generación y uso de patrones isotópicos en comparación fenotípica de espectros de masas de organismos
US8628977B2 (en) * 2008-05-02 2014-01-14 Purdue Research Foundation Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules
JP5299956B2 (ja) 2008-09-29 2013-09-25 国立大学法人東北大学 質量分析装置を用いた代謝酵素群の一斉タンパク質定量に用いるペプチド
JP5317336B2 (ja) 2009-02-23 2013-10-16 国立大学法人東北大学 質量分析装置を用いたタンパク質定量のための評価用ペプチド、人工標準タンパク質、及びタンパク質の定量方法
WO2010120946A1 (en) * 2009-04-14 2010-10-21 Institute For Systems Biology Improvements in mass spectrum-based identification and quantitation of proteins and peptides
US20130095514A1 (en) * 2010-03-12 2013-04-18 Jpt Peptide Technologies Gmbh Method for Determining the Concentration of a Peptide
CA3214092A1 (en) * 2011-03-15 2012-09-20 Massachusetts Institute Of Technology Multiplexed detection with isotope-coded reporters
EP2735871B1 (de) 2011-07-22 2017-12-06 Tohoku University Verfahren zur herstellung von mit stabilen isotopen gekennzeichneten zielpeptidfragmenten in der massenspektrometrie
CN105452481A (zh) 2013-06-07 2016-03-30 麻省理工学院 基于亲和力检测配体编码的合成性生物标记物
MX2020009617A (es) * 2018-03-16 2020-12-07 Quest Diagnostics Invest Llc Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente.
CN109444279A (zh) * 2018-11-06 2019-03-08 北京蛋白世界生物科技有限公司 一种15n代谢标记蛋白质结合质谱平行反应监测定量的方法
CN109438551B (zh) * 2018-11-06 2024-05-28 北京蛋白世界生物科技有限公司 一种微量蛋白质样品浓缩的方法
EP3911753A1 (de) 2019-01-17 2021-11-24 Massachusetts Institute of Technology Sensoren zur erfassung und abbildung von krebsmetastasen
CN110044988B (zh) * 2019-04-26 2021-01-29 常州大学 一种弯曲毛细管电泳检测多酶的方法

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US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
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ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
CN1149398C (zh) * 1999-01-20 2004-05-12 宝洁公司 多肽测序的方法和试剂盒

Also Published As

Publication number Publication date
EP1392848A2 (de) 2004-03-03
US7045296B2 (en) 2006-05-16
WO2002090929A3 (en) 2003-09-25
US20020192720A1 (en) 2002-12-19
AU2002340828A1 (en) 2002-11-18
DE60217328T2 (de) 2007-07-19
JP2004533610A (ja) 2004-11-04
ATE350666T1 (de) 2007-01-15
WO2002090929A2 (en) 2002-11-14
EP1392848B1 (de) 2007-01-03
EP1392848A4 (de) 2005-06-22
JP4188701B2 (ja) 2008-11-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US

Owner name: THE INSTITUTE FOR SYSTEMS BIOLOGY, SEATTLE, MA, US