DE60213230D1 - Verwendung von NF-Kappa.B Inhibitoren zur Behandlung von Augentrockenheit - Google Patents
Verwendung von NF-Kappa.B Inhibitoren zur Behandlung von AugentrockenheitInfo
- Publication number
- DE60213230D1 DE60213230D1 DE60213230T DE60213230T DE60213230D1 DE 60213230 D1 DE60213230 D1 DE 60213230D1 DE 60213230 T DE60213230 T DE 60213230T DE 60213230 T DE60213230 T DE 60213230T DE 60213230 D1 DE60213230 D1 DE 60213230D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- kappa
- dry eye
- treat dry
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29249501P | 2001-05-21 | 2001-05-21 | |
US292495P | 2001-05-21 | ||
PCT/US2002/015859 WO2002095704A1 (en) | 2001-05-21 | 2002-05-17 | Use of nf-kappa-b inhibitors to treat dry eye disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60213230D1 true DE60213230D1 (de) | 2006-08-31 |
DE60213230T2 DE60213230T2 (de) | 2006-11-23 |
Family
ID=23124921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60213230T Expired - Lifetime DE60213230T2 (de) | 2001-05-21 | 2002-05-17 | Verwendung von NF-Kappa.B Inhibitoren zur Behandlung von Augentrockenheit |
Country Status (17)
Country | Link |
---|---|
US (1) | US6696453B2 (de) |
EP (1) | EP1393277B1 (de) |
JP (1) | JP2004527578A (de) |
CN (1) | CN1509462A (de) |
AT (1) | ATE333273T1 (de) |
AU (1) | AU2002309963B2 (de) |
BR (1) | BR0209965A (de) |
CA (1) | CA2447883A1 (de) |
CY (1) | CY1105220T1 (de) |
DE (1) | DE60213230T2 (de) |
DK (1) | DK1393277T3 (de) |
ES (1) | ES2263785T3 (de) |
MX (1) | MXPA03010632A (de) |
PL (1) | PL367286A1 (de) |
PT (1) | PT1393277E (de) |
WO (1) | WO2002095704A1 (de) |
ZA (1) | ZA200308769B (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA05003063A (es) * | 2002-09-20 | 2005-05-27 | Alcon Inc | Uso de inhibidores de la sintesis de citosina para el tratamiento de trastornos de ojos secos. |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991759A (en) | 1975-10-28 | 1976-11-16 | Alza Corporation | Method and therapeutic system for treating aqueous deficient dry eye |
US4131651A (en) | 1977-10-25 | 1978-12-26 | Barnes-Hind Pharmaceuticals, Inc. | Treatment of dry eye |
US4409205A (en) | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
US4370325A (en) | 1979-03-30 | 1983-01-25 | Dermik Laboratories | Pharmaceutical compositions and method of treatment |
US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
US4883658A (en) | 1986-04-28 | 1989-11-28 | Holly Frank J | Ophthalmic solution for treatment of dry-eye syndrome |
US4744980A (en) | 1986-04-28 | 1988-05-17 | Holly Frank J | Ophthalmic solution for treatment of dry eye syndrome |
US4804539A (en) | 1986-07-28 | 1989-02-14 | Liposome Technology, Inc. | Ophthalmic liposomes |
US4818537A (en) | 1986-10-21 | 1989-04-04 | Liposome Technology, Inc. | Liposome composition for treating dry eye |
US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
US4914088A (en) | 1987-04-02 | 1990-04-03 | Thomas Glonek | Dry eye treatment solution and method |
US5278151A (en) | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
US4996209A (en) | 1988-06-20 | 1991-02-26 | Alcon Laboratories, Inc. | Ophthalmic antiinflammatory compositions comprising S(+)-flurbiprofen |
US5075104A (en) | 1989-03-31 | 1991-12-24 | Alcon Laboratories, Inc. | Ophthalmic carboxy vinyl polymer gel for dry eye syndrome |
US5174988A (en) | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
US5583150A (en) | 1989-08-18 | 1996-12-10 | Alcon Laboratories, Inc. | 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases |
US5041434A (en) | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
ZA912797B (en) | 1990-05-29 | 1992-12-30 | Boston Ocular Res | Dry eye treatment process and solution |
ATE132366T1 (de) | 1990-05-29 | 1996-01-15 | Boston Ocular Res | Zusammensetzung zur behandlung von dry eye erkrankungen |
DE4028906A1 (de) | 1990-09-12 | 1992-03-19 | Paz Arzneimittelentwicklung | Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen |
DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
ZA927277B (en) | 1991-10-02 | 1993-05-19 | Boston Ocular Res | Dry eye treatment process and solution. |
DE4140184C2 (de) | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Flurbiprofen enthaltendes Arzneimittel |
DE69326836T2 (de) | 1992-04-21 | 2000-02-24 | Schepens Eye Res Inst | Androgentherapie am auge beim sjögrensyndrom |
US5958912A (en) * | 1992-04-21 | 1999-09-28 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β |
US5290572A (en) | 1992-08-06 | 1994-03-01 | Deo Corporation | Opthalmic composition for treating dry eye |
US5686436A (en) | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
US5561161A (en) | 1994-03-25 | 1996-10-01 | Oxigene, Inc. | Methods of administering and pharmaceutical formulations containing n-substituted benzamides and/or acid addition salts thereof |
FR2718441B1 (fr) | 1994-04-07 | 1996-06-28 | Bioxytech | Nouveaux composés de structure benzisoséléna-zoline et -zine, leur procédé de préparation et leurs applications thérapeutiques. |
US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
AU715430B2 (en) | 1995-08-14 | 2000-02-03 | Optigenex, Inc. | Carotenoid-nicotinamide-zinc compositions and methods of treatment using same |
US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
WO1997020578A1 (en) * | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
US6028111A (en) | 1996-03-08 | 2000-02-22 | Oxigene, Inc. | Compositions and use of benzamides and nicotinamides as anti-inflammatory agents |
US6100299A (en) | 1996-03-08 | 2000-08-08 | Oxigene, Inc. | N-acetyl 3-chloroprocainamide, acid addition salts thereof, and methods of use |
US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
US6071904A (en) | 1996-12-11 | 2000-06-06 | Alcon Laboratories, Inc. | Process for manufacturing ophthalmic suspensions |
US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
US6043083A (en) | 1997-04-28 | 2000-03-28 | Davis; Roger J. | Inhibitors of the JNK signal transduction pathway and methods of use |
US5916910A (en) | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
US6207458B1 (en) | 1998-05-07 | 2001-03-27 | University Of Washigton/Stowers Insitute For Medical Research | Proteins capable of regulating NF-κB JNK and apoptosis pathways and methods of using the same |
JP2002520355A (ja) * | 1998-07-14 | 2002-07-09 | アルコン ラボラトリーズ, インコーポレイテッド | 非アレルギー性眼炎症障害を処置および眼新生血管形成を予防する医薬製造のための、11−(3−ジメチルアミノプロピリデン)−6,11−ジヒドロジベンズ[b,e]オキセピン−2−酢酸の使用 |
WO2000043000A1 (fr) | 1999-01-20 | 2000-07-27 | Kyowa Hakko Kogyo Co., Ltd. | Inhibiteurs de proteasome |
US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
DE60011889T2 (de) | 1999-04-27 | 2005-07-14 | Novartis Ag | 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren |
-
2002
- 2002-05-17 CN CNA028102061A patent/CN1509462A/zh active Pending
- 2002-05-17 EP EP02736994A patent/EP1393277B1/de not_active Expired - Lifetime
- 2002-05-17 CA CA002447883A patent/CA2447883A1/en not_active Abandoned
- 2002-05-17 DK DK02736994T patent/DK1393277T3/da active
- 2002-05-17 JP JP2002592087A patent/JP2004527578A/ja active Pending
- 2002-05-17 AT AT02736994T patent/ATE333273T1/de active
- 2002-05-17 AU AU2002309963A patent/AU2002309963B2/en not_active Ceased
- 2002-05-17 MX MXPA03010632A patent/MXPA03010632A/es active IP Right Grant
- 2002-05-17 PT PT02736994T patent/PT1393277E/pt unknown
- 2002-05-17 US US10/150,219 patent/US6696453B2/en not_active Expired - Lifetime
- 2002-05-17 WO PCT/US2002/015859 patent/WO2002095704A1/en active IP Right Grant
- 2002-05-17 BR BR0209965-9A patent/BR0209965A/pt not_active IP Right Cessation
- 2002-05-17 PL PL02367286A patent/PL367286A1/xx not_active Application Discontinuation
- 2002-05-17 DE DE60213230T patent/DE60213230T2/de not_active Expired - Lifetime
- 2002-05-17 ES ES02736994T patent/ES2263785T3/es not_active Expired - Lifetime
-
2003
- 2003-11-11 ZA ZA2003/08769A patent/ZA200308769B/en unknown
-
2006
- 2006-09-14 CY CY20061101314T patent/CY1105220T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
BR0209965A (pt) | 2004-04-06 |
WO2002095704A8 (en) | 2003-09-18 |
US6696453B2 (en) | 2004-02-24 |
AU2002309963B2 (en) | 2007-03-01 |
PL367286A1 (en) | 2005-02-21 |
US20030008854A1 (en) | 2003-01-09 |
EP1393277A1 (de) | 2004-03-03 |
EP1393277B1 (de) | 2006-07-19 |
CN1509462A (zh) | 2004-06-30 |
PT1393277E (pt) | 2006-09-29 |
JP2004527578A (ja) | 2004-09-09 |
ES2263785T3 (es) | 2006-12-16 |
DE60213230T2 (de) | 2006-11-23 |
WO2002095704A9 (en) | 2003-02-27 |
ZA200308769B (en) | 2005-01-26 |
ATE333273T1 (de) | 2006-08-15 |
MXPA03010632A (es) | 2004-03-09 |
CY1105220T1 (el) | 2010-03-03 |
WO2002095704A1 (en) | 2002-11-28 |
DK1393277T3 (da) | 2006-10-30 |
CA2447883A1 (en) | 2002-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |