DE60203283D1 - 6h-oxazolo[4,5-e]indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden - Google Patents

6h-oxazolo[4,5-e]indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden

Info

Publication number
DE60203283D1
DE60203283D1 DE60203283T DE60203283T DE60203283D1 DE 60203283 D1 DE60203283 D1 DE 60203283D1 DE 60203283 T DE60203283 T DE 60203283T DE 60203283 T DE60203283 T DE 60203283T DE 60203283 D1 DE60203283 D1 DE 60203283D1
Authority
DE
Germany
Prior art keywords
ligands
serotonerges
oxazolo
indol derivatives
nicotinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60203283T
Other languages
English (en)
Other versions
DE60203283T2 (de
Inventor
Kai Schiemann
Henning Boettcher
Joachim Leibrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE60203283T priority Critical patent/DE60203283T2/de
Publication of DE60203283D1 publication Critical patent/DE60203283D1/de
Application granted granted Critical
Publication of DE60203283T2 publication Critical patent/DE60203283T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
DE60203283T 2001-04-30 2002-04-05 6h-oxazolo[4,5-e]indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden Expired - Lifetime DE60203283T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE60203283T DE60203283T2 (de) 2001-04-30 2002-04-05 6h-oxazolo[4,5-e]indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10121217A DE10121217A1 (de) 2001-04-30 2001-04-30 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
DE10121217 2001-04-30
DE60203283T DE60203283T2 (de) 2001-04-30 2002-04-05 6h-oxazolo[4,5-e]indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden
PCT/EP2002/003784 WO2002088139A1 (en) 2001-04-30 2002-04-05 6h-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands

Publications (2)

Publication Number Publication Date
DE60203283D1 true DE60203283D1 (de) 2005-04-21
DE60203283T2 DE60203283T2 (de) 2006-03-30

Family

ID=7683302

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10121217A Withdrawn DE10121217A1 (de) 2001-04-30 2001-04-30 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
DE60203283T Expired - Lifetime DE60203283T2 (de) 2001-04-30 2002-04-05 6h-oxazolo[4,5-e]indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10121217A Withdrawn DE10121217A1 (de) 2001-04-30 2001-04-30 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden

Country Status (13)

Country Link
US (2) US7291633B2 (de)
EP (1) EP1392699B1 (de)
JP (1) JP4485746B2 (de)
AR (1) AR033267A1 (de)
AT (1) ATE291026T1 (de)
AU (1) AU2002257752B2 (de)
CA (1) CA2445835C (de)
CZ (1) CZ20033194A3 (de)
DE (2) DE10121217A1 (de)
ES (1) ES2239226T3 (de)
HU (1) HUP0304034A2 (de)
SK (1) SK14482003A3 (de)
WO (1) WO2002088139A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10121217A1 (de) * 2001-04-30 2002-10-31 Merck Patent Gmbh 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
CA2482639A1 (en) * 2002-05-30 2003-12-11 Neurosearch A/S 3-substituted quinuclidines and their use
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
US9125900B2 (en) * 2005-09-14 2015-09-08 University Of The Witwatersrand, Johannesburg Pharmaceutical composition
RS58700B1 (sr) 2012-10-12 2019-06-28 Broad Inst Inc Gsk3 inhibitori i postupci njihove primene
EP3004892B1 (de) * 2013-05-24 2018-10-10 Nestec S.A. Methode zur diagnostizierung des reizdarmsyndroms
CA3058198A1 (en) * 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0510068T3 (da) 1990-01-11 1999-10-25 Upjohn Co Nye 6,7,8,9-tetrahydro-3H-benz(e)indol-heterocycler med virkning på centralnervesystemet
TW263508B (de) * 1991-02-12 1995-11-21 Pfizer
JP3155008B2 (ja) 1994-07-26 2001-04-09 ファイザー・インコーポレーテッド セロトニンアゴニストおよびアンタゴニストとしての４−インドール誘導体
WO1997012862A1 (en) * 1995-10-03 1997-04-10 The Scripps Research Institute Cbi analogs of cc-1065 and the duocarmycins
ATE241615T1 (de) 1998-03-09 2003-06-15 Lundbeck & Co As H 5-heteroaryl-substituierte indole
DE10045112A1 (de) 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
DE10121217A1 (de) * 2001-04-30 2002-10-31 Merck Patent Gmbh 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden

Also Published As

Publication number Publication date
EP1392699A1 (de) 2004-03-03
US7741343B2 (en) 2010-06-22
CA2445835A1 (en) 2002-11-07
JP4485746B2 (ja) 2010-06-23
CZ20033194A3 (cs) 2004-02-18
EP1392699B1 (de) 2005-03-16
HUP0304034A2 (hu) 2004-04-28
JP2004527562A (ja) 2004-09-09
DE10121217A1 (de) 2002-10-31
AU2002257752B2 (en) 2008-02-28
DE60203283T2 (de) 2006-03-30
SK14482003A3 (sk) 2004-03-02
US20080051394A1 (en) 2008-02-28
CA2445835C (en) 2012-01-03
WO2002088139A1 (en) 2002-11-07
ES2239226T3 (es) 2005-09-16
US20050101649A1 (en) 2005-05-12
AR033267A1 (es) 2003-12-10
ATE291026T1 (de) 2005-04-15
US7291633B2 (en) 2007-11-06

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