DE60201890D1 - Synthese von beta-lapachone und entsprechender zwischenprodukte - Google Patents

Synthese von beta-lapachone und entsprechender zwischenprodukte

Info

Publication number
DE60201890D1
DE60201890D1 DE60201890T DE60201890T DE60201890D1 DE 60201890 D1 DE60201890 D1 DE 60201890D1 DE 60201890 T DE60201890 T DE 60201890T DE 60201890 T DE60201890 T DE 60201890T DE 60201890 D1 DE60201890 D1 DE 60201890D1
Authority
DE
Germany
Prior art keywords
lapachone
beta
synthesis
lapachol
interim products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60201890T
Other languages
English (en)
Other versions
DE60201890T2 (de
Inventor
Zhiwei Jiang
Jane Hogeland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arqule Inc
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of DE60201890D1 publication Critical patent/DE60201890D1/de
Application granted granted Critical
Publication of DE60201890T2 publication Critical patent/DE60201890T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DE60201890T 2001-01-25 2002-01-23 Synthese von beta-lapachone und entsprechender zwischenprodukte Expired - Lifetime DE60201890T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26411601P 2001-01-25 2001-01-25
US264116P 2001-01-25
US957260 2001-09-19
US09/957,260 US6458974B1 (en) 2001-01-25 2001-09-19 Synthesis of β-lapachone and its intermediates
PCT/US2002/002359 WO2002059103A1 (en) 2001-01-25 2002-01-23 Synthesis of beta-lapachone and its intermediates

Publications (2)

Publication Number Publication Date
DE60201890D1 true DE60201890D1 (de) 2004-12-16
DE60201890T2 DE60201890T2 (de) 2005-12-08

Family

ID=26950263

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60201890T Expired - Lifetime DE60201890T2 (de) 2001-01-25 2002-01-23 Synthese von beta-lapachone und entsprechender zwischenprodukte

Country Status (9)

Country Link
US (1) US6458974B1 (de)
EP (1) EP1363896B1 (de)
JP (1) JP4434585B2 (de)
AT (1) ATE282033T1 (de)
AU (1) AU2002241985B2 (de)
CA (1) CA2436125C (de)
DE (1) DE60201890T2 (de)
ES (1) ES2230471T3 (de)
WO (1) WO2002059103A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222246A1 (en) * 1999-04-14 2005-10-06 Li Chiang J Beta-lapachone is a broad spectrum anti-cancer agent
US20050192360A1 (en) * 1999-04-14 2005-09-01 Li Chiang J. Method of treatment of pancreatic cancer
US20050197405A1 (en) * 2000-11-07 2005-09-08 Li Chiang J. Treatment of hematologic tumors and cancers with beta-lapachone, a broad spectrum anti-cancer agent
US6816571B2 (en) * 2002-02-06 2004-11-09 L-3 Communications Security And Detection Systems Corporation Delaware Method and apparatus for transmitting information about a target object between a prescanner and a CT scanner
EP1545507A4 (de) * 2002-07-17 2009-04-22 Arqule Inc Aktiverte checkpunkt-therapie und anwendungsverfahren daf r
AU2003293333A1 (en) 2002-12-02 2004-06-23 Arqule, Inc. Method of treating cancers
EP2033639A2 (de) 2004-02-20 2009-03-11 Arqule, Inc. Beta-Lapachon zur Behandlung von Dickdarmkrebs
JP2007523193A (ja) 2004-02-20 2007-08-16 アークル・インコーポレーテツド 膵癌の治療のためのβ−ラパコンの使用
JP2007523190A (ja) 2004-02-20 2007-08-16 アークル・インコーポレーテツド 肺癌の治療のためのβ−ラパコンの使用
US20050187288A1 (en) * 2004-02-20 2005-08-25 Chiang Li Beta-lapachone and methods of treating cancer
US20050192247A1 (en) * 2004-02-23 2005-09-01 Li Chiang J. Method of treating cancers
US8614228B2 (en) * 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
WO2006020722A2 (en) * 2004-08-11 2006-02-23 Arqule, Inc. Polymer conjugates of beta-lapachone and beta-lapachone analogs for tumor targeting
WO2006078503A2 (en) 2005-01-07 2006-07-27 Arqule, Inc. Compositions for modulation of parp and methods for screening for same
US7790765B2 (en) * 2007-04-30 2010-09-07 Arqule, Inc. Hydroxy sulfonate of quinone compounds and their uses
CN103239430B (zh) * 2013-05-08 2015-01-07 首都医科大学 拉帕醇在制备预防和/或治疗恶性胶质瘤的产品中的应用
CN105294638A (zh) * 2015-10-30 2016-02-03 成都科创佳思科技有限公司 一种去氢α-拉帕醌的催化合成方法
WO2018085705A1 (en) 2016-11-03 2018-05-11 Repairogen Corp Cosmetic compositions containing quinones and their topical use on skin and hair
US11013673B2 (en) 2016-11-03 2021-05-25 Repairogen Corp. Cosmetic compositions containing quinones and their topical use on skin and hair
WO2019213494A1 (en) 2018-05-03 2019-11-07 Repairogen Corp Cosmetic compositions containing quinones and their topical use on skin and hair
CN113372298B (zh) * 2021-05-21 2022-04-19 温州医科大学 一种2-碘-3-胺基萘醌化合物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824700A (en) * 1996-02-20 1998-10-20 Wisconsin Alumni Research Foundation Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth

Also Published As

Publication number Publication date
CA2436125C (en) 2009-03-31
JP2004520378A (ja) 2004-07-08
WO2002059103A1 (en) 2002-08-01
ES2230471T3 (es) 2005-05-01
US20020137952A1 (en) 2002-09-26
WO2002059103A9 (en) 2003-01-03
AU2002241985B2 (en) 2006-01-19
JP4434585B2 (ja) 2010-03-17
DE60201890T2 (de) 2005-12-08
ATE282033T1 (de) 2004-11-15
CA2436125A1 (en) 2002-08-01
EP1363896A1 (de) 2003-11-26
US6458974B1 (en) 2002-10-01
EP1363896B1 (de) 2004-11-10

Similar Documents

Publication Publication Date Title
DE60201890D1 (de) Synthese von beta-lapachone und entsprechender zwischenprodukte
ATE361924T1 (de) Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
HUP9602685A2 (hu) Helyettesített kinolin-2-karbonsav-amidok, eljárás előállításukra és alkalmazásuk gyógyszerekként, valamint közbenső termékek
BR0013885A (pt) Comprimidos aperfeiçoados
PL392726A1 (pl) Nowe związki pośrednie do syntezy związków triazolopirymidyny oraz sposób ich wytwarzania
HK1023987A1 (en) Sulphinic acid derivatives, method for producing, and their use
HUT54119A (en) Process for producing antiinflammatory aminophenol derivatives
NO306614B1 (no) Derivater i vitamin D-serien modifisert ved 20-stilling, mellomprodukter anvendt ved fremstilling av disse, farmasöytiske preparater inneholdende derivatene og deres anvendelse ved fremstilling av legemidler
ATE341541T1 (de) Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy- pyran-2-one
ES2132609T3 (es) Derivados del acido arilacetico y su empleo como fungicidas.
DE69325253T2 (de) 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
ATE442355T1 (de) Herstellung von 4,5-dialkyl-3-acylpyrrol-2- carbonsäurederivaten durch synthese nach fischer- fink und anschliebende acylierung
UA27022C2 (uk) Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу
ES8602792A1 (es) Procedimiento para preparar derivados de purina
ATE509117T1 (de) Herstellungsverfahren für hyaluronsäure oder ihre derivate
ATE166642T1 (de) 9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln
ATE61589T1 (de) Isohexid-nukleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
TR200400907T4 (tr) Beta D 5-Tiyoksiloz türevleri, bunları hazırlama yöntemi ve bunların terapötik kullanımları
AU5844800A (en) Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid
AU3814800A (en) Enantiomers of mercapto lactones and processes for their synthesis
HUP0302158A2 (hu) Eljárás disztamicinszármazékok elżállítására
DE60108112D1 (de) Verfahren zur herstellung von carbostyril-derivaten
HUP0402365A2 (hu) Eljárás alkaloidok reagáltatására, és a reakciótermékek alkalmazása gyógyszerkészítmény előállítására
ATE93525T1 (de) Umwandlung eines delta-16-steroids in einen delta-17(20)-20 silylether.
NO179324C (no) Fremgangsmåte for fremstilling av 5-kloroksindol

Legal Events

Date Code Title Description
8364 No opposition during term of opposition