DE602008006545D1 - Neues stereospezifisches Verfahren zur Herstellung von Dioxabicyclooctan-Verbindungen - Google Patents
Neues stereospezifisches Verfahren zur Herstellung von Dioxabicyclooctan-VerbindungenInfo
- Publication number
- DE602008006545D1 DE602008006545D1 DE602008006545T DE602008006545T DE602008006545D1 DE 602008006545 D1 DE602008006545 D1 DE 602008006545D1 DE 602008006545 T DE602008006545 T DE 602008006545T DE 602008006545 T DE602008006545 T DE 602008006545T DE 602008006545 D1 DE602008006545 D1 DE 602008006545D1
- Authority
- DE
- Germany
- Prior art keywords
- dioxabicyclooctane
- compounds
- preparation
- stereospecific process
- new stereospecific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- LPMTVTDWWATVQO-UHFFFAOYSA-N 3-cyclooctyldioxocane Chemical class C1CCCCCCC1C1OOCCCCC1 LPMTVTDWWATVQO-UHFFFAOYSA-N 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08380221A EP2149576A1 (de) | 2008-07-22 | 2008-07-22 | Isosorbitnitrate mit vasodilatierender Wirksamkeit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602008006545D1 true DE602008006545D1 (de) | 2011-06-09 |
Family
ID=39800661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602008006545T Active DE602008006545D1 (de) | 2008-07-22 | 2008-11-14 | Neues stereospezifisches Verfahren zur Herstellung von Dioxabicyclooctan-Verbindungen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8211939B2 (de) |
| EP (2) | EP2149576A1 (de) |
| JP (1) | JP2011528691A (de) |
| KR (1) | KR20110039562A (de) |
| CN (1) | CN102124010B (de) |
| AR (1) | AR072591A1 (de) |
| AT (1) | ATE507230T1 (de) |
| AU (1) | AU2009273233B2 (de) |
| BR (1) | BRPI0916532A2 (de) |
| CA (1) | CA2731574A1 (de) |
| DE (1) | DE602008006545D1 (de) |
| ES (2) | ES2365688T3 (de) |
| MX (1) | MX2011000808A (de) |
| UY (1) | UY32001A (de) |
| WO (1) | WO2010010101A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2149576A1 (de) * | 2008-07-22 | 2010-02-03 | Lacer, S.A. | Isosorbitnitrate mit vasodilatierender Wirksamkeit |
| RU2015139514A (ru) * | 2013-03-05 | 2017-04-07 | Арчер Дэниелс Мидлэнд Компани | Монотрифлаты изогексида и способ их синтеза |
| US10691097B2 (en) | 2014-05-09 | 2020-06-23 | The Boeing Company | Path repeatable machining for full sized determinant assembly |
| US10501471B1 (en) * | 2018-11-04 | 2019-12-10 | John F. Schmedtje, Jr. | Compounds useful for treating cardiovascular diseases |
| US10913748B2 (en) * | 2018-11-04 | 2021-02-09 | Coeurative, Inc. | Compounds useful for treating cardiovascular diseases |
| CN113683623B (zh) * | 2021-09-09 | 2022-08-12 | 中国人民解放军空军军医大学 | 一种no供体化合物及其制备方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3028289C2 (de) * | 1980-07-25 | 1986-11-27 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| JP2628756B2 (ja) | 1988-09-15 | 1997-07-09 | シュバルツファルマ アクチェンゲゼルシャフト | 新規有機ニトレート及びそれらの製造方法 |
| US4891373A (en) | 1988-11-23 | 1990-01-02 | Pfizer Inc. | Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments |
| NL9001955A (nl) | 1990-09-05 | 1992-04-01 | Cedona Pharm Bv | Nieuwe thiazolidinederivaten. |
| FR2680173A1 (fr) * | 1991-08-07 | 1993-02-12 | Hoechst Lab | Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires . |
| JPH07509484A (ja) | 1992-07-30 | 1995-10-19 | シーエーエル・インターナショナル・リミテッド | 有機硝酸塩とサリチル酸塩とのエステル及び混合物 |
| ES2142773B1 (es) * | 1998-10-07 | 2001-01-01 | Lacer Sa | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. |
| ES2258365B1 (es) | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
| EP1941876A1 (de) * | 2006-12-28 | 2008-07-09 | Lacer, S.A. | Isosorbidmononitrit Derivate zur Behandlung von der Inflammation und okularen Hypertension |
| EP2149576A1 (de) * | 2008-07-22 | 2010-02-03 | Lacer, S.A. | Isosorbitnitrate mit vasodilatierender Wirksamkeit |
-
2008
- 2008-07-22 EP EP08380221A patent/EP2149576A1/de not_active Withdrawn
- 2008-11-14 ES ES08380318T patent/ES2365688T3/es active Active
- 2008-11-14 DE DE602008006545T patent/DE602008006545D1/de active Active
- 2008-11-14 AT AT08380318T patent/ATE507230T1/de not_active IP Right Cessation
- 2008-11-17 ES ES200803270A patent/ES2341075B1/es not_active Expired - Fee Related
- 2008-12-15 US US12/334,986 patent/US8211939B2/en not_active Expired - Fee Related
-
2009
- 2009-07-21 CN CN2009801321115A patent/CN102124010B/zh not_active Expired - Fee Related
- 2009-07-21 WO PCT/EP2009/059387 patent/WO2010010101A1/en active Application Filing
- 2009-07-21 JP JP2011519153A patent/JP2011528691A/ja active Pending
- 2009-07-21 KR KR1020117003953A patent/KR20110039562A/ko not_active Application Discontinuation
- 2009-07-21 AU AU2009273233A patent/AU2009273233B2/en not_active Ceased
- 2009-07-21 BR BRPI0916532A patent/BRPI0916532A2/pt not_active IP Right Cessation
- 2009-07-21 CA CA2731574A patent/CA2731574A1/en not_active Abandoned
- 2009-07-21 MX MX2011000808A patent/MX2011000808A/es active IP Right Grant
- 2009-07-21 EP EP09800052A patent/EP2324033B1/de not_active Not-in-force
- 2009-07-21 UY UY0001032001A patent/UY32001A/es not_active Application Discontinuation
- 2009-07-22 AR ARP090102783A patent/AR072591A1/es unknown
-
2012
- 2012-04-05 US US13/439,894 patent/US20120189616A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110039562A (ko) | 2011-04-19 |
| EP2324033A1 (de) | 2011-05-25 |
| BRPI0916532A2 (pt) | 2015-11-10 |
| UY32001A (es) | 2010-02-26 |
| ES2365688T3 (es) | 2011-10-10 |
| WO2010010101A1 (en) | 2010-01-28 |
| ES2341075B1 (es) | 2011-03-01 |
| EP2149576A1 (de) | 2010-02-03 |
| ATE507230T1 (de) | 2011-05-15 |
| CN102124010B (zh) | 2013-12-18 |
| AU2009273233A1 (en) | 2010-01-28 |
| US20100022638A1 (en) | 2010-01-28 |
| US8211939B2 (en) | 2012-07-03 |
| US20120189616A1 (en) | 2012-07-26 |
| WO2010010101A8 (en) | 2011-03-10 |
| AU2009273233B2 (en) | 2013-03-28 |
| ES2341075A1 (es) | 2010-06-14 |
| MX2011000808A (es) | 2011-05-30 |
| JP2011528691A (ja) | 2011-11-24 |
| CA2731574A1 (en) | 2010-01-28 |
| EP2324033B1 (de) | 2012-08-22 |
| AR072591A1 (es) | 2010-09-08 |
| CN102124010A (zh) | 2011-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602007013512D1 (de) | Verfahren zur kontinuierlichen Herstellung von Bauteilen | |
| DE602008000298D1 (de) | Verfahren zur Herstellung von Polyesternanokompositen | |
| DE602007011843D1 (de) | Verfahren zur Herstellung von Gruppe-III-Nitridkristallen | |
| DE502008002995D1 (de) | Verfahren zur Herstellung von Alkalimetallalkoholaten | |
| DE102010037160A8 (de) | Verfahren zur Herstellung von Zahnersatz | |
| DE502008000147D1 (de) | Verfahren zur Herstellung von Organyloxygruppen aufweisenden Organosiliciumverbindungen | |
| DE502007003700D1 (de) | Verfahren zur Herstellung von Glycerin | |
| DE602007001585D1 (de) | Verfahren zur herstellung von kunstlatex | |
| DE602007009096D1 (de) | Verfahren zur herstellung von benzopyran-2-olderivaten | |
| DK2285779T3 (da) | Fremgangsmåde til fremstilling af arylcarboxamider | |
| DE602008006421D1 (de) | Verfahren zur Herstellung von organischen polymerischen Profilen | |
| ATE548345T1 (de) | Verfahren zur herstellung von agomelatin | |
| ATE546436T1 (de) | Verfahren zur herstellung von 2-amino-5- cyanobenzoesäurederivaten | |
| DE602006010302D1 (de) | Verfahren zur Herstellung von 5-methyl-2-furfural | |
| DE502008000313D1 (de) | Verfahren zur kontinuierlichen Herstellung von Aminoalkylgruppen aufweisenden Organopolysiloxanen | |
| DE102009012161B8 (de) | Verfahren zur Herstellung von Polysaccharidderivaten | |
| DE102010002164A8 (de) | Verfahren zur Herstellung von beschichteten Formkörpern | |
| DE502007000129D1 (de) | Kontinuierliches Verfahren zur Herstellung von vernetzbaren Organopolysiloxanmassen | |
| DE602006009562D1 (de) | Verfahren zur herstellung von ferrisuccinylcasein | |
| DE602008006545D1 (de) | Neues stereospezifisches Verfahren zur Herstellung von Dioxabicyclooctan-Verbindungen | |
| DE502007000875D1 (de) | Verfahren zur Herstellung von ß-Ketocarbonyl-funktionellen Organosiliciumverbindungen | |
| DE502008000793D1 (de) | Mehrstufiges Verfahren zur Herstellung von Aminoalkylgruppen aufweisenden Organopolysiloxanen | |
| LU91718B1 (de) | Verfahren zur Herstellung von Schuhen | |
| DE502006000023D1 (de) | Verfahren zur Herstellung von Silanolgruppen aufweisenden Organopolysiloxanen | |
| DE502007000339D1 (de) | Verfahren zur Herstellung von Urethangruppen aufweisenden Organosiliciumverbindungen |