DE602008006209D1 - 1-(4-(4-benzylbenzamid)-benzyl)-azetidin-3-carboxylsäurederivate und entsprechende verbindungen als s1p-rezeptor-modulatoren zur behandlung von immunerkrankungen - Google Patents
1-(4-(4-benzylbenzamid)-benzyl)-azetidin-3-carboxylsäurederivate und entsprechende verbindungen als s1p-rezeptor-modulatoren zur behandlung von immunerkrankungenInfo
- Publication number
- DE602008006209D1 DE602008006209D1 DE602008006209T DE602008006209T DE602008006209D1 DE 602008006209 D1 DE602008006209 D1 DE 602008006209D1 DE 602008006209 T DE602008006209 T DE 602008006209T DE 602008006209 T DE602008006209 T DE 602008006209T DE 602008006209 D1 DE602008006209 D1 DE 602008006209D1
- Authority
- DE
- Germany
- Prior art keywords
- benzylbenzamid
- azetidine
- benzyl
- treatment
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99481207P | 2007-09-20 | 2007-09-20 | |
| PCT/US2008/010887 WO2009038759A2 (en) | 2007-09-20 | 2008-09-19 | 1-(4-(benzylbenzamid0) -benzyl) azetidine-3-carboxylic acid derivatives and related compounds as slp receptor modulators for the treatment of immune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602008006209D1 true DE602008006209D1 (de) | 2011-05-26 |
Family
ID=40468694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602008006209T Active DE602008006209D1 (de) | 2007-09-20 | 2008-09-19 | 1-(4-(4-benzylbenzamid)-benzyl)-azetidin-3-carboxylsäurederivate und entsprechende verbindungen als s1p-rezeptor-modulatoren zur behandlung von immunerkrankungen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8080542B2 (de) |
| EP (1) | EP2188252B1 (de) |
| JP (1) | JP2010540438A (de) |
| AT (1) | ATE505454T1 (de) |
| AU (1) | AU2008302746B2 (de) |
| CA (1) | CA2699417A1 (de) |
| DE (1) | DE602008006209D1 (de) |
| ES (1) | ES2360929T3 (de) |
| MX (1) | MX2010002885A (de) |
| WO (1) | WO2009038759A2 (de) |
Families Citing this family (33)
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| US7855193B2 (en) | 2005-11-23 | 2010-12-21 | Epix Pharmaceuticals, Inc. | S1P receptor modulating compounds and use thereof |
| US7919519B2 (en) | 2005-11-23 | 2011-04-05 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
| US7790707B2 (en) | 2006-03-21 | 2010-09-07 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
| WO2009011850A2 (en) * | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| AU2008302746B2 (en) | 2007-09-20 | 2014-07-03 | Amgen Inc. | 1-(4-(benzylbenzamid0) -benzyl) azetidine-3-carboxylic acid derivatives and related compounds as SlP receptor modulators for the treatment of immune disorders |
| TW201000099A (en) * | 2008-06-20 | 2010-01-01 | Amgen Inc | S1P1 receptor agonists and use thereof |
| US8791100B2 (en) * | 2010-02-02 | 2014-07-29 | Novartis Ag | Aryl benzylamine compounds |
| KR20130115311A (ko) | 2010-11-24 | 2013-10-21 | 알러간, 인코포레이티드 | S1p 수용체의 조절제 |
| FR3017867A1 (fr) * | 2014-02-21 | 2015-08-28 | Inventiva | Nouveaux composes de type phenylazetidine carboxylate ou carboxamide |
| US9718771B2 (en) | 2014-02-28 | 2017-08-01 | Kissei Pharmaceutical Co., Ltd. | Aniline derivative, pharmaceutical composition containing same, and use thereof |
| US9895324B2 (en) | 2014-03-26 | 2018-02-20 | University Of Kentucky Research Foundation | Halogenated diarylacetylenes and methods of treating cancer |
| US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| PL3377488T3 (pl) | 2015-11-19 | 2022-12-19 | Incyte Corporation | Związki heterocykliczne jako immunomodulatory |
| MD3394033T2 (ro) | 2015-12-22 | 2021-04-30 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| US20170320875A1 (en) | 2016-05-06 | 2017-11-09 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2017205464A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MY197280A (en) | 2016-06-20 | 2023-06-09 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| EP3484866B1 (de) | 2016-07-14 | 2022-09-07 | Incyte Corporation | Heterocyclische verbindungen als immunmodulatoren |
| WO2018044783A1 (en) | 2016-08-29 | 2018-03-08 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MD3558990T2 (ro) | 2016-12-22 | 2023-02-28 | Incyte Corp | Derivați tetrahidro imidazo[4,5-c]piridină ca inductori de internalizare a PD-L1 |
| KR20190111025A (ko) | 2016-12-22 | 2019-10-01 | 인사이트 코포레이션 | 면역조절제로서의 벤조옥사졸 유도체 |
| WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
| PE20211911A1 (es) | 2018-03-30 | 2021-09-28 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores |
| JOP20200288A1 (ar) | 2018-05-11 | 2020-11-11 | Incyte Corp | مشتقات تترا هيدرو – إيميدازو[4، 5-c]بيريدين كمعدِّلات مناعية pd-l1 |
| AR119624A1 (es) | 2019-08-09 | 2021-12-29 | Incyte Corp | Sales de un inhibidor de pd-1 / pd-l1 |
| EP4037773A1 (de) | 2019-09-30 | 2022-08-10 | Incyte Corporation | Pyrido[3,2-d]pyrimidin-verbindungen als immunmodulatoren |
| KR20220101664A (ko) | 2019-11-11 | 2022-07-19 | 인사이트 코포레이션 | Pd-1/pd-l1 억제제의 염 및 결정질 형태 |
| PE20231438A1 (es) | 2020-11-06 | 2023-09-14 | Incyte Corp | Proceso para hacer un inhibidor de pd-1/pd-l1 y sales y formas cristalinas del mismo |
| WO2022099075A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Crystalline form of a pd-1/pd-l1 inhibitor |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| CN113332435B (zh) * | 2021-06-18 | 2022-10-18 | 广州中医药大学(广州中医药研究院) | 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用 |
| WO2023018643A1 (en) | 2021-08-10 | 2023-02-16 | Abbvie Inc. | Nicotinamide ripk1 inhibitors |
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| US7790707B2 (en) | 2006-03-21 | 2010-09-07 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
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| CN101790519B (zh) * | 2007-08-08 | 2013-10-16 | 默克雪兰诺有限公司 | 用于治疗多发性硬化症的结合于鞘氨醇1-磷酸(s1p)的6-氨基-嘧啶-4-羧酰胺衍生物及相关化合物 |
| AU2008302746B2 (en) | 2007-09-20 | 2014-07-03 | Amgen Inc. | 1-(4-(benzylbenzamid0) -benzyl) azetidine-3-carboxylic acid derivatives and related compounds as SlP receptor modulators for the treatment of immune disorders |
| US7939546B2 (en) * | 2007-10-12 | 2011-05-10 | Supergen, Inc. | Quinoline derivatives for modulating DNA methylation |
-
2008
- 2008-09-19 AU AU2008302746A patent/AU2008302746B2/en not_active Ceased
- 2008-09-19 JP JP2010525834A patent/JP2010540438A/ja active Pending
- 2008-09-19 ES ES08831946T patent/ES2360929T3/es active Active
- 2008-09-19 DE DE602008006209T patent/DE602008006209D1/de active Active
- 2008-09-19 CA CA2699417A patent/CA2699417A1/en not_active Abandoned
- 2008-09-19 EP EP08831946A patent/EP2188252B1/de active Active
- 2008-09-19 MX MX2010002885A patent/MX2010002885A/es active IP Right Grant
- 2008-09-19 AT AT08831946T patent/ATE505454T1/de not_active IP Right Cessation
- 2008-09-19 WO PCT/US2008/010887 patent/WO2009038759A2/en active Application Filing
- 2008-09-19 US US12/234,514 patent/US8080542B2/en not_active Expired - Fee Related
-
2011
- 2011-12-16 US US13/327,951 patent/US20120088749A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2188252B1 (de) | 2011-04-13 |
| US8080542B2 (en) | 2011-12-20 |
| EP2188252A2 (de) | 2010-05-26 |
| ATE505454T1 (de) | 2011-04-15 |
| ES2360929T3 (es) | 2011-06-10 |
| JP2010540438A (ja) | 2010-12-24 |
| US20120088749A1 (en) | 2012-04-12 |
| CA2699417A1 (en) | 2009-03-26 |
| MX2010002885A (es) | 2010-04-01 |
| WO2009038759A3 (en) | 2009-07-23 |
| AU2008302746A1 (en) | 2009-03-26 |
| US20090082331A1 (en) | 2009-03-26 |
| AU2008302746B2 (en) | 2014-07-03 |
| WO2009038759A2 (en) | 2009-03-26 |
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