DE602008005172D1 - Markierungsfreier einzelzelltest - Google Patents
Markierungsfreier einzelzelltestInfo
- Publication number
- DE602008005172D1 DE602008005172D1 DE602008005172T DE602008005172T DE602008005172D1 DE 602008005172 D1 DE602008005172 D1 DE 602008005172D1 DE 602008005172 T DE602008005172 T DE 602008005172T DE 602008005172 T DE602008005172 T DE 602008005172T DE 602008005172 D1 DE602008005172 D1 DE 602008005172D1
- Authority
- DE
- Germany
- Prior art keywords
- single cell
- marking
- cell test
- free single
- biosensor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/21—Polarisation-affecting properties
- G01N21/211—Ellipsometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99790807P | 2007-10-06 | 2007-10-06 | |
US12/128,267 US8703428B2 (en) | 2007-10-06 | 2008-05-28 | Single-cell label-free assay |
PCT/US2008/011404 WO2009045465A1 (en) | 2007-10-06 | 2008-10-02 | Single-cell label-free assay |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602008005172D1 true DE602008005172D1 (de) | 2011-04-07 |
Family
ID=40523597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602008005172T Active DE602008005172D1 (de) | 2007-10-06 | 2008-10-02 | Markierungsfreier einzelzelltest |
Country Status (6)
Country | Link |
---|---|
US (1) | US8703428B2 (de) |
EP (1) | EP2195639B1 (de) |
JP (1) | JP2010540963A (de) |
AT (1) | ATE499598T1 (de) |
DE (1) | DE602008005172D1 (de) |
WO (1) | WO2009045465A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10203320B2 (en) | 2008-11-11 | 2019-02-12 | Corning Incorporated | Label free method for assessing chemical cardiotoxicity |
JP2010154847A (ja) * | 2008-11-25 | 2010-07-15 | Corning Inc | パルス刺激下の細胞信号伝達を調べる方法及び装置 |
WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
FR2983213B1 (fr) * | 2011-11-30 | 2015-03-06 | Commissariat Energie Atomique | Procede de mesure en temps reel des secretions individuelles d'une cellule |
US20190008859A1 (en) | 2015-08-21 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor |
WO2021150686A1 (en) | 2020-01-22 | 2021-07-29 | Firmenich Incorporated | High-sensitivity detection of gpcr activity and uses thereof |
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US4631605A (en) * | 1984-09-20 | 1986-12-23 | Ampex Corporation | Multiple speed scanner servo system for protecting the heads and tape of helical recorders |
WO1986007149A1 (de) * | 1985-05-29 | 1986-12-04 | Kurt Tiefenthaler | Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahländerungen in messubstanzen |
US5830766A (en) | 1990-05-23 | 1998-11-03 | Ares-Serono Research & Development Ltd. Partnership | Enhanced signal-to-noise ratio and sensitivity optical immunoassay |
US5305074A (en) * | 1992-07-17 | 1994-04-19 | The United States Of America As Represented By The United States Department Of Energy | Achromatic self-referencing interferometer |
US5512492A (en) | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
GB9314991D0 (en) * | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
US6130792A (en) * | 1995-11-13 | 2000-10-10 | Seagate Technology, Inc. | Flat servo bursts for arcuate track scanner |
US5847892A (en) * | 1995-11-13 | 1998-12-08 | Seagate Technology, Inc. | Servoing and formatting magnetic recording tape in an arcuate scanner system |
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WO1999005962A1 (en) * | 1997-07-31 | 1999-02-11 | Case Western Reserve University | A system and method for non-invasive electrocardiographic imaging |
CA2311487C (en) * | 1998-05-13 | 2004-02-10 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
EP1192448B1 (de) * | 1999-07-05 | 2006-09-27 | Novartis AG | Verfahren zur anwendung einer sensoreinheit |
US6771376B2 (en) * | 1999-07-05 | 2004-08-03 | Novartis Ag | Sensor platform, apparatus incorporating the platform, and process using the platform |
WO2001057530A1 (en) | 2000-02-03 | 2001-08-09 | Immunomatrix Inc. | Method and apparatus for signal transduction pathway profiling |
US6893850B2 (en) * | 2000-03-17 | 2005-05-17 | President And Fellows Of Harvard College | Method for cell patterning |
JP2003533692A (ja) | 2000-05-06 | 2003-11-11 | ツェプトゼンス アクチエンゲゼルシャフト | 多重分析対象物測定及びその使用のための格子導波路構造 |
WO2002008762A1 (en) | 2000-07-21 | 2002-01-31 | Thaumdx, Llc | Apparatus and method for evanescent light fluoroassays |
AU2001281633A1 (en) | 2000-08-09 | 2002-02-18 | Artificial Sensing Instruments Asi Ag | Detection method |
JP3795312B2 (ja) * | 2000-09-06 | 2006-07-12 | 独立行政法人科学技術振興機構 | 細胞活性の評価方法 |
US7202076B2 (en) * | 2000-10-30 | 2007-04-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US6951715B2 (en) * | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7175980B2 (en) * | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
US7070987B2 (en) * | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
US7217574B2 (en) * | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
US7142296B2 (en) * | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
US20030113766A1 (en) * | 2000-10-30 | 2003-06-19 | Sru Biosystems, Llc | Amine activated colorimetric resonant biosensor |
US7153702B2 (en) * | 2000-10-30 | 2006-12-26 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
US7023544B2 (en) * | 2000-10-30 | 2006-04-04 | Sru Biosystems, Inc. | Method and instrument for detecting biomolecular interactions |
US20030092075A1 (en) * | 2000-10-30 | 2003-05-15 | Sru Biosystems, Llc | Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors |
US7118710B2 (en) * | 2000-10-30 | 2006-10-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US7306827B2 (en) * | 2000-10-30 | 2007-12-11 | Sru Biosystems, Inc. | Method and machine for replicating holographic gratings on a substrate |
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US20030194755A1 (en) | 2001-04-27 | 2003-10-16 | Genoptix, Inc. | Early detection of apoptotic events and apoptosis using optophoretic analysis |
US20040009540A1 (en) | 2001-04-27 | 2004-01-15 | Genoptix, Inc | Detection and evaluation of cancer cells using optophoretic analysis |
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US6893705B2 (en) * | 2001-05-25 | 2005-05-17 | Massachusetts Institute Of Technology | Large area orientation of block copolymer microdomains in thin films |
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US20040053209A1 (en) | 2002-09-12 | 2004-03-18 | Genoptix, Inc | Detection and evaluation of topoisomerase inhibitors using optophoretic analysis |
US20040091397A1 (en) * | 2002-11-07 | 2004-05-13 | Corning Incorporated | Multiwell insert device that enables label free detection of cells and other objects |
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US20060223051A1 (en) * | 2005-04-05 | 2006-10-05 | Ye Fang | System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors |
JP5129119B2 (ja) * | 2005-04-05 | 2013-01-23 | コーニング インコーポレイテッド | 標識フリーバイオセンサおよび細胞 |
US20080233561A1 (en) | 2005-07-20 | 2008-09-25 | University Of Louisville Research Foundation, Inc. | Method for Measuring Cytopathic Effect Due to Viral Infection in Cells Using Electric Cell-Substrate Impedance Sensing |
CN104076162A (zh) | 2005-07-20 | 2014-10-01 | 康宁股份有限公司 | 无标记高通量生物分子筛选系统和方法 |
-
2008
- 2008-05-28 US US12/128,267 patent/US8703428B2/en not_active Expired - Fee Related
- 2008-10-02 AT AT08836091T patent/ATE499598T1/de not_active IP Right Cessation
- 2008-10-02 WO PCT/US2008/011404 patent/WO2009045465A1/en active Application Filing
- 2008-10-02 DE DE602008005172T patent/DE602008005172D1/de active Active
- 2008-10-02 EP EP08836091A patent/EP2195639B1/de not_active Not-in-force
- 2008-10-02 JP JP2010527986A patent/JP2010540963A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US20090093013A1 (en) | 2009-04-09 |
US8703428B2 (en) | 2014-04-22 |
JP2010540963A (ja) | 2010-12-24 |
EP2195639B1 (de) | 2011-02-23 |
EP2195639A1 (de) | 2010-06-16 |
ATE499598T1 (de) | 2011-03-15 |
WO2009045465A1 (en) | 2009-04-09 |
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