DE602007014036D1 - 12-aryl-prostaglandin-analoga - Google Patents
12-aryl-prostaglandin-analogaInfo
- Publication number
- DE602007014036D1 DE602007014036D1 DE602007014036T DE602007014036T DE602007014036D1 DE 602007014036 D1 DE602007014036 D1 DE 602007014036D1 DE 602007014036 T DE602007014036 T DE 602007014036T DE 602007014036 T DE602007014036 T DE 602007014036T DE 602007014036 D1 DE602007014036 D1 DE 602007014036D1
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- prostaglandin analogues
- disclosed
- prostaglandin
- analogues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74627506P | 2006-05-03 | 2006-05-03 | |
| US74638606P | 2006-05-04 | 2006-05-04 | |
| US11/742,987 US7439372B2 (en) | 2006-05-03 | 2007-05-01 | Therapeutic compounds |
| PCT/US2007/067985 WO2007131012A1 (en) | 2006-05-03 | 2007-05-02 | 12-aryl or heteroaryl prostaglandin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007014036D1 true DE602007014036D1 (de) | 2011-06-01 |
Family
ID=38474466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007014036T Active DE602007014036D1 (de) | 2006-05-03 | 2007-05-02 | 12-aryl-prostaglandin-analoga |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7439372B2 (enExample) |
| EP (1) | EP2027082B1 (enExample) |
| JP (1) | JP5247680B2 (enExample) |
| AT (1) | ATE506340T1 (enExample) |
| AU (1) | AU2007248119B2 (enExample) |
| BR (1) | BRPI0711159A2 (enExample) |
| CA (1) | CA2651022C (enExample) |
| DE (1) | DE602007014036D1 (enExample) |
| WO (1) | WO2007131012A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US20090016981A1 (en) | 2006-05-03 | 2009-01-15 | Allergan, Inc. | Therapeutic compounds |
| JP5532302B2 (ja) | 2006-07-10 | 2014-06-25 | アラーガン インコーポレイテッド | 治療化合物 |
| CN101952261B (zh) * | 2007-11-09 | 2013-06-12 | 阿勒根公司 | 具有前列腺素活性的取代环戊烷 |
| MX364408B (es) † | 2007-12-20 | 2019-04-25 | Univ Southern California | Aparatos y metodos para suministrar agentes terapeuticos. |
| US8198318B2 (en) * | 2008-03-18 | 2012-06-12 | Allergen, Inc. | Therapeutic amides |
| US7713968B2 (en) | 2008-04-24 | 2010-05-11 | Allergan, Inc. | Substituted arylcyclopentenes as therapeutic agents |
| ATE550328T1 (de) | 2008-04-24 | 2012-04-15 | Allergan Inc | Thiophenderivate, die sich als den augeninnendruck senkende mittel eignen |
| EP2297084A1 (en) * | 2008-04-24 | 2011-03-23 | Allergan, Inc. | Therapeutic compounds |
| EP2598140B1 (en) * | 2010-07-30 | 2015-01-14 | Allergan, Inc. | Prostanoid ep4 agonists for use in treating a skin blemish |
| US20120142684A1 (en) * | 2010-12-02 | 2012-06-07 | Allergan, Inc. | Compounds and methods for skin repair |
| US9000032B2 (en) | 2013-05-31 | 2015-04-07 | Allergan, Inc. | Substituted cyclopentenes as therapeutic agents |
| JP6482547B2 (ja) | 2013-10-31 | 2019-03-13 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | プロスタミド含有眼内インプラント及びそれらの使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JPH09506894A (ja) | 1993-12-20 | 1997-07-08 | 藤沢薬品工業株式会社 | ４，５−ジアリールオキサゾール誘導体 |
| US5462968A (en) | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
| EP0795331B1 (en) | 1995-11-14 | 2002-04-10 | Toray Industries, Inc. | Ocular depressor |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| PE20020444A1 (es) | 2000-09-22 | 2002-06-14 | Merck & Co Inc | Antagonistas de receptores de taquiquinina zwitterionica |
| CN1617868A (zh) | 2001-11-05 | 2005-05-18 | 阿勒根公司 | 作为EP2－受体激动剂的ω－环烷基17－杂芳基前列腺素E2 类似物 |
| US7235586B2 (en) * | 2003-09-09 | 2007-06-26 | Allergan, Inc. | Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents |
-
2007
- 2007-05-01 US US11/742,987 patent/US7439372B2/en active Active
- 2007-05-02 EP EP07761718A patent/EP2027082B1/en not_active Not-in-force
- 2007-05-02 CA CA2651022A patent/CA2651022C/en not_active Expired - Fee Related
- 2007-05-02 DE DE602007014036T patent/DE602007014036D1/de active Active
- 2007-05-02 JP JP2009510043A patent/JP5247680B2/ja not_active Expired - Fee Related
- 2007-05-02 AU AU2007248119A patent/AU2007248119B2/en not_active Ceased
- 2007-05-02 WO PCT/US2007/067985 patent/WO2007131012A1/en not_active Ceased
- 2007-05-02 AT AT07761718T patent/ATE506340T1/de not_active IP Right Cessation
- 2007-05-02 BR BRPI0711159-2A patent/BRPI0711159A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2651022C (en) | 2014-08-19 |
| EP2027082A1 (en) | 2009-02-25 |
| US7439372B2 (en) | 2008-10-21 |
| US20070259947A1 (en) | 2007-11-08 |
| ATE506340T1 (de) | 2011-05-15 |
| WO2007131012A1 (en) | 2007-11-15 |
| JP2009535426A (ja) | 2009-10-01 |
| AU2007248119B2 (en) | 2012-07-05 |
| JP5247680B2 (ja) | 2013-07-24 |
| WO2007131012A9 (en) | 2009-01-08 |
| AU2007248119A1 (en) | 2007-11-15 |
| CA2651022A1 (en) | 2007-11-15 |
| BRPI0711159A2 (pt) | 2011-08-23 |
| EP2027082B1 (en) | 2011-04-20 |
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