DE602007010445D1 - Verfahren zur synthese von (+) und (-)-1-aryl-3-azabicycloä3.1.0ühexanen - Google Patents
Verfahren zur synthese von (+) und (-)-1-aryl-3-azabicycloä3.1.0ühexanenInfo
- Publication number
- DE602007010445D1 DE602007010445D1 DE602007010445T DE602007010445T DE602007010445D1 DE 602007010445 D1 DE602007010445 D1 DE 602007010445D1 DE 602007010445 T DE602007010445 T DE 602007010445T DE 602007010445 T DE602007010445 T DE 602007010445T DE 602007010445 D1 DE602007010445 D1 DE 602007010445D1
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- enhexanes
- synthesis
- azabicyclo
- hexanes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79608606P | 2006-04-28 | 2006-04-28 | |
PCT/US2007/010324 WO2007127421A2 (en) | 2006-04-28 | 2007-04-27 | Process for the synthesis of (+) and (-)-1-aryl-3-azabicyclo[3.1.0]hexanes |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007010445D1 true DE602007010445D1 (de) | 2010-12-23 |
Family
ID=38565602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007010445T Active DE602007010445D1 (de) | 2006-04-28 | 2007-04-27 | Verfahren zur synthese von (+) und (-)-1-aryl-3-azabicycloä3.1.0ühexanen |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100204486A1 (de) |
EP (1) | EP2016053B1 (de) |
AT (1) | ATE487699T1 (de) |
DE (1) | DE602007010445D1 (de) |
WO (1) | WO2007127421A2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
CA2659215C (en) | 2005-07-27 | 2018-07-10 | Dov Pharmaceutical, Inc. | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
KR101044277B1 (ko) | 2008-08-22 | 2011-06-28 | 한양대학교 산학협력단 | 삼각고리를 포함하는 바이사이클로 퓨란 유도체 및 그 제조방법 |
EP2621902B1 (de) | 2010-09-28 | 2017-04-12 | Panacea Biotec Ltd | 3-azabicyclo[3.1.0]hexanverbindungen zur behandlung von zns-erkrankungen |
CN114634441B (zh) * | 2022-05-16 | 2022-07-26 | 南京海辰药业股份有限公司 | 一种合成6,6-二甲基-3-氮杂双环[3,1,0]己烷的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4196120A (en) * | 1975-07-31 | 1980-04-01 | American Cyanamid Company | Azabicyclohexanes, method of use and preparation of the same |
MXPA05004381A (es) * | 2002-10-25 | 2006-02-10 | Collegium Pharmaceutical Inc | Estereoisomeros de para-hidroxi-milnacipran y metodos de uso de los mismos. |
US20060223875A1 (en) * | 2005-03-08 | 2006-10-05 | Phil Skolnick | Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0]hexanes |
CA2659215C (en) * | 2005-07-27 | 2018-07-10 | Dov Pharmaceutical, Inc. | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
US20080045725A1 (en) * | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
-
2007
- 2007-04-27 EP EP07794404A patent/EP2016053B1/de not_active Not-in-force
- 2007-04-27 WO PCT/US2007/010324 patent/WO2007127421A2/en active Application Filing
- 2007-04-27 US US12/226,801 patent/US20100204486A1/en not_active Abandoned
- 2007-04-27 DE DE602007010445T patent/DE602007010445D1/de active Active
- 2007-04-27 AT AT07794404T patent/ATE487699T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2007127421A2 (en) | 2007-11-08 |
US20100204486A1 (en) | 2010-08-12 |
ATE487699T1 (de) | 2010-11-15 |
EP2016053B1 (de) | 2010-11-10 |
EP2016053A2 (de) | 2009-01-21 |
WO2007127421A3 (en) | 2008-01-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200802054A1 (ru) | Ингибиторы фермента | |
DE602007010445D1 (de) | Verfahren zur synthese von (+) und (-)-1-aryl-3-azabicycloä3.1.0ühexanen | |
WO2008130320A3 (en) | Novel n- (8-heteroaryltetrahydronaphtalene-2yl) or n- (5- heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain | |
ATE519488T1 (de) | Aminopyrazin-analoga zur behandlung von glaukomen und anderen durch rho-kinase verursachten krankheiten | |
GEP20084551B (en) | 4-phenylamino-quinazolin-6-yl-amides | |
MX2010009561A (es) | Compuestos amida, composiciones y usos de los mismos. | |
EA200970296A1 (ru) | Содержащие диариловый эфир соединения мочевины | |
BRPI0508051A (pt) | derivados de heteroarilaminopirazol utilizáveis para o tratamento de diabetes | |
EP2826472A3 (de) | Telomerase aktivierende Verbindungen und ihre Verwendung | |
ATE538651T1 (de) | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
CY1111327T1 (el) | Υποκατεστημενα παραγωγα κυκλοεξυλοξεικου οξεος | |
EA200802020A1 (ru) | Тетрагидропиримидоазепины и их применение в качестве модуляторов trpv 1 | |
DE60318839D1 (de) | 2,6-chinolinyl- und 2,6-naphthylderivate und deren verwendungen zur behandlung von vla-4 bezogenen krankheiten | |
ATE469646T1 (de) | Pyrazolo-heteroaryl-verbindungen zur behandlung tnf-alpha- und il-1-vermittelter krankheiten | |
MA32943B1 (fr) | Piperidine spiro pyrrolidione et piperidinone substituees, leur preparation et leur utilisation therapeutique | |
ATE509621T1 (de) | Verwendung von 2,5-dihydroxybenzolderivaten zur behandlung von arthritis und schmerzen | |
SI1853232T1 (sl) | Stabilna kristalna oblika bifeprunoks-mezilata, njegove dozirne oblike in postopki za njihovo uporabo | |
ATE357453T1 (de) | Comt-inhibitoren | |
ATE538796T1 (de) | Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit | |
ATE524463T1 (de) | 4-chromenonyl-1,4-dihydropyridincarbonitrile und ihre verwendung | |
HK1127899A1 (en) | Process for the synthesis of (+) and (-) -1-(3,4-dichlorophenyl)-3- azabicyclo[3.1.0]hexane | |
WO2008130319A3 (en) | Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain | |
WO2005082884A3 (en) | 2-pyridin-2yl-pyrimidine derivatives useful in the treatment of gastro-esophagea l reflux disease | |
BRPI0509582A (pt) | compostos de tiazol-amina e respectivas composições farmacêuticas | |
DE602004025935D1 (de) | Histondeacetylaseinhibitor und verfahren zu dessen herstellung |