WO2005082884A3 - 2-pyridin-2yl-pyrimidine derivatives useful in the treatment of gastro-esophagea l reflux disease - Google Patents

2-pyridin-2yl-pyrimidine derivatives useful in the treatment of gastro-esophagea l reflux disease Download PDF

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Publication number
WO2005082884A3
WO2005082884A3 PCT/US2005/004751 US2005004751W WO2005082884A3 WO 2005082884 A3 WO2005082884 A3 WO 2005082884A3 US 2005004751 W US2005004751 W US 2005004751W WO 2005082884 A3 WO2005082884 A3 WO 2005082884A3
Authority
WO
WIPO (PCT)
Prior art keywords
esophagea
gastro
pyridin
treatment
pyrimidine derivatives
Prior art date
Application number
PCT/US2005/004751
Other languages
French (fr)
Other versions
WO2005082884A2 (en
Inventor
Martin Johansson
Jonas Malmstroem
Alexander Minidis
Karolina Nilsson
David Wensbo
Andreas Waallberg
Krister Oesterlund
Original Assignee
Astrazeneca Ab
Nps Pharma Inc
Martin Johansson
Jonas Malmstroem
Alexander Minidis
Karolina Nilsson
David Wensbo
Andreas Waallberg
Krister Oesterlund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Nps Pharma Inc, Martin Johansson, Jonas Malmstroem, Alexander Minidis, Karolina Nilsson, David Wensbo, Andreas Waallberg, Krister Oesterlund filed Critical Astrazeneca Ab
Publication of WO2005082884A2 publication Critical patent/WO2005082884A2/en
Publication of WO2005082884A3 publication Critical patent/WO2005082884A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
PCT/US2005/004751 2004-02-20 2005-02-15 2-pyridin-2yl-pyrimidine derivatives useful in the treatment of gastro-esophagea l reflux disease WO2005082884A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54590504P 2004-02-20 2004-02-20
US60/545,905 2004-02-20

Publications (2)

Publication Number Publication Date
WO2005082884A2 WO2005082884A2 (en) 2005-09-09
WO2005082884A3 true WO2005082884A3 (en) 2006-05-18

Family

ID=34910738

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004751 WO2005082884A2 (en) 2004-02-20 2005-02-15 2-pyridin-2yl-pyrimidine derivatives useful in the treatment of gastro-esophagea l reflux disease

Country Status (4)

Country Link
AR (1) AR047967A1 (en)
TW (1) TW200538180A (en)
UY (1) UY28762A1 (en)
WO (1) WO2005082884A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2001849E (en) * 2006-03-29 2015-02-05 Hoffmann La Roche Pyridine and pyrimidine derivatives as mglur2 antagonists
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
AR080056A1 (en) 2010-02-01 2012-03-07 Novartis Ag CICLOHEXIL-AMIDA DERIVATIVES AS ANTAGONISTS OF CRF RECEIVERS
ES2527849T3 (en) 2010-02-02 2015-01-30 Novartis Ag Cyclohexylamide derivatives as CRF receptor antagonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407899A2 (en) * 1989-07-11 1991-01-16 Hoechst Schering AgrEvo GmbH Aminopyrimidine derivatives, process for their preparation, agent containing them and their use as fungicides
DE4029649A1 (en) * 1990-09-19 1992-03-26 Hoechst Ag New 2-pyridyl-pyrimidine derivs. - useful as fungicides
WO2001051045A2 (en) * 2000-01-13 2001-07-19 Tularik Inc. Modulators of the constitutive adrostane receptor (car): screening and treatment of hypercholesterolemia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407899A2 (en) * 1989-07-11 1991-01-16 Hoechst Schering AgrEvo GmbH Aminopyrimidine derivatives, process for their preparation, agent containing them and their use as fungicides
DE4029649A1 (en) * 1990-09-19 1992-03-26 Hoechst Ag New 2-pyridyl-pyrimidine derivs. - useful as fungicides
WO2001051045A2 (en) * 2000-01-13 2001-07-19 Tularik Inc. Modulators of the constitutive adrostane receptor (car): screening and treatment of hypercholesterolemia

Also Published As

Publication number Publication date
AR047967A1 (en) 2006-03-15
TW200538180A (en) 2005-12-01
WO2005082884A2 (en) 2005-09-09
UY28762A1 (en) 2005-08-31

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