AR047967A1 - PIRIMIDINE DERIVATIVES USEFUL TO TREAT GASTRO-ESOFAGIC REFLECTION DISEASES. - Google Patents

PIRIMIDINE DERIVATIVES USEFUL TO TREAT GASTRO-ESOFAGIC REFLECTION DISEASES.

Info

Publication number
AR047967A1
AR047967A1 ARP050100614A ARP050100614A AR047967A1 AR 047967 A1 AR047967 A1 AR 047967A1 AR P050100614 A ARP050100614 A AR P050100614A AR P050100614 A ARP050100614 A AR P050100614A AR 047967 A1 AR047967 A1 AR 047967A1
Authority
AR
Argentina
Prior art keywords
diseases
derivatives useful
esofagic
reflection
halogen
Prior art date
Application number
ARP050100614A
Other languages
Spanish (es)
Original Assignee
Nps Pharma Inc
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Pharma Inc, Astrazeneca Ab filed Critical Nps Pharma Inc
Publication of AR047967A1 publication Critical patent/AR047967A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de pirimidina utiles para tratar enfermedades de reflujo gastro-esofágico, proceso para su preparacion, su uso en terapia y composiciones farmacéuticas que comprenden dichos compuestos. Reivindicacion 1: Un compuesto de formula (1) caracterizado porque R1, R2, R3 y R4 se seleccionan cada uno y en forma independientemente entre H, alquilo C1-4, halogeno, CN y NO2; R5 y R6 se seleccionan cada uno y en forma independiente entre hora, halogeno, CN y NO2; Q es arilo o heteroarilo, opcionalmente sustituido por H, alquilo C1-4, alquenilo C2-4, halogeno, alcoxi, CH2F, CHF2, CF3, NH2, NHAc., OH, OAc o ésteres carboxílicos y donde uno o más de los sustituyentes puede formar parte de un anillo; así como sales, hidratos, isoformas y/o isomeros opticos de los mismos aceptables para uso farmacéutico.Pyrimidine derivatives useful for treating gastro-esophageal reflux diseases, process for their preparation, their use in therapy and pharmaceutical compositions comprising said compounds. Claim 1: A compound of formula (1) characterized in that R1, R2, R3 and R4 are each independently selected from H, C1-4 alkyl, halogen, CN and NO2; R5 and R6 are each independently selected from time, halogen, CN and NO2; Q is aryl or heteroaryl, optionally substituted by H, C1-4 alkyl, C2-4 alkenyl, halogen, alkoxy, CH2F, CHF2, CF3, NH2, NHAc., OH, OAc or carboxylic esters and where one or more of the substituents it can be part of a ring; as well as salts, hydrates, isoforms and / or optical isomers thereof acceptable for pharmaceutical use.

ARP050100614A 2004-02-20 2005-02-18 PIRIMIDINE DERIVATIVES USEFUL TO TREAT GASTRO-ESOFAGIC REFLECTION DISEASES. AR047967A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54590504P 2004-02-20 2004-02-20

Publications (1)

Publication Number Publication Date
AR047967A1 true AR047967A1 (en) 2006-03-15

Family

ID=34910738

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100614A AR047967A1 (en) 2004-02-20 2005-02-18 PIRIMIDINE DERIVATIVES USEFUL TO TREAT GASTRO-ESOFAGIC REFLECTION DISEASES.

Country Status (4)

Country Link
AR (1) AR047967A1 (en)
TW (1) TW200538180A (en)
UY (1) UY28762A1 (en)
WO (1) WO2005082884A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008012413A (en) * 2006-03-29 2008-10-07 Hoffmann La Roche Pyridine and pyrimidine derivatives as mglur2 antagonists.
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
AR080055A1 (en) 2010-02-01 2012-03-07 Novartis Ag DERIVATIVES OF PIRAZOLO- [5,1-B] -OXAZOL AS ANTAGONISTS OF THE RECEIVERS OF CRF -1
AR080056A1 (en) 2010-02-01 2012-03-07 Novartis Ag CICLOHEXIL-AMIDA DERIVATIVES AS ANTAGONISTS OF CRF RECEIVERS
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3922735A1 (en) * 1989-07-11 1991-01-24 Hoechst Ag AMINOPYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEY AND THEIR USE AS FUNGICIDES
DE4029649A1 (en) * 1990-09-19 1992-03-26 Hoechst Ag New 2-pyridyl-pyrimidine derivs. - useful as fungicides
WO2001051045A2 (en) * 2000-01-13 2001-07-19 Tularik Inc. Modulators of the constitutive adrostane receptor (car): screening and treatment of hypercholesterolemia

Also Published As

Publication number Publication date
WO2005082884A3 (en) 2006-05-18
WO2005082884A2 (en) 2005-09-09
TW200538180A (en) 2005-12-01
UY28762A1 (en) 2005-08-31

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