AR047967A1 - Derivados de pirimidina utiles para tratar enfermedades de reflujo gastro-esofagico. - Google Patents
Derivados de pirimidina utiles para tratar enfermedades de reflujo gastro-esofagico.Info
- Publication number
- AR047967A1 AR047967A1 ARP050100614A ARP050100614A AR047967A1 AR 047967 A1 AR047967 A1 AR 047967A1 AR P050100614 A ARP050100614 A AR P050100614A AR P050100614 A ARP050100614 A AR P050100614A AR 047967 A1 AR047967 A1 AR 047967A1
- Authority
- AR
- Argentina
- Prior art keywords
- diseases
- derivatives useful
- esofagic
- reflection
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de pirimidina utiles para tratar enfermedades de reflujo gastro-esofágico, proceso para su preparacion, su uso en terapia y composiciones farmacéuticas que comprenden dichos compuestos. Reivindicacion 1: Un compuesto de formula (1) caracterizado porque R1, R2, R3 y R4 se seleccionan cada uno y en forma independientemente entre H, alquilo C1-4, halogeno, CN y NO2; R5 y R6 se seleccionan cada uno y en forma independiente entre hora, halogeno, CN y NO2; Q es arilo o heteroarilo, opcionalmente sustituido por H, alquilo C1-4, alquenilo C2-4, halogeno, alcoxi, CH2F, CHF2, CF3, NH2, NHAc., OH, OAc o ésteres carboxílicos y donde uno o más de los sustituyentes puede formar parte de un anillo; así como sales, hidratos, isoformas y/o isomeros opticos de los mismos aceptables para uso farmacéutico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54590504P | 2004-02-20 | 2004-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR047967A1 true AR047967A1 (es) | 2006-03-15 |
Family
ID=34910738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050100614A AR047967A1 (es) | 2004-02-20 | 2005-02-18 | Derivados de pirimidina utiles para tratar enfermedades de reflujo gastro-esofagico. |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR047967A1 (es) |
TW (1) | TW200538180A (es) |
UY (1) | UY28762A1 (es) |
WO (1) | WO2005082884A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101415681A (zh) * | 2006-03-29 | 2009-04-22 | 弗·哈夫曼-拉罗切有限公司 | 作为mGluR2拮抗剂的吡啶和嘧啶衍生物 |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | CRF−1受容体アンタゴニストとしてのピラゾロ[5,1b]オキサゾール誘導体 |
AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Crf受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
DE4029649A1 (de) * | 1990-09-19 | 1992-03-26 | Hoechst Ag | Alkoxypyridyl-pyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
US20020152479A1 (en) * | 2000-01-13 | 2002-10-17 | Lehmann Jurgen M. | Car modulators: screening and treatment of hypercholesterolemia |
-
2005
- 2005-02-05 TW TW094104002A patent/TW200538180A/zh unknown
- 2005-02-15 WO PCT/US2005/004751 patent/WO2005082884A2/en active Application Filing
- 2005-02-18 UY UY28762A patent/UY28762A1/es unknown
- 2005-02-18 AR ARP050100614A patent/AR047967A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2005082884A3 (en) | 2006-05-18 |
TW200538180A (en) | 2005-12-01 |
UY28762A1 (es) | 2005-08-31 |
WO2005082884A2 (en) | 2005-09-09 |
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Legal Events
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