DE602007005820D1 - Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitoren - Google Patents

Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitoren

Info

Publication number
DE602007005820D1
DE602007005820D1 DE602007005820T DE602007005820T DE602007005820D1 DE 602007005820 D1 DE602007005820 D1 DE 602007005820D1 DE 602007005820 T DE602007005820 T DE 602007005820T DE 602007005820 T DE602007005820 T DE 602007005820T DE 602007005820 D1 DE602007005820 D1 DE 602007005820D1
Authority
DE
Germany
Prior art keywords
resulting
trna synthetase
aminoacyl
substance
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007005820T
Other languages
English (en)
Inventor
De Pouplana Lluis Ribas
Sanz Teresa Bori
De Moura Manuel Castro
Renaud Geslain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institucio Catalana de Recerca i Estudis Avancats ICREA
Fundacio Privada Parc Cientific de Barcelona
Fundacio Privada Institut de Recerca Biomedica IRB
Original Assignee
Institucio Catalana de Recerca i Estudis Avancats ICREA
Fundacio Privada Parc Cientific de Barcelona
Fundacio Privada Institut de Recerca Biomedica IRB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institucio Catalana de Recerca i Estudis Avancats ICREA, Fundacio Privada Parc Cientific de Barcelona, Fundacio Privada Institut de Recerca Biomedica IRB filed Critical Institucio Catalana de Recerca i Estudis Avancats ICREA
Publication of DE602007005820D1 publication Critical patent/DE602007005820D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/9015—Ligases (6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE602007005820T 2006-09-04 2007-08-30 Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitoren Active DE602007005820D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06120049 2006-09-04
PCT/EP2007/059063 WO2008028862A1 (en) 2006-09-04 2007-08-30 A screening method for identifying new aminoacyl-trna synthetase inhibitors

Publications (1)

Publication Number Publication Date
DE602007005820D1 true DE602007005820D1 (de) 2010-05-20

Family

ID=38606618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007005820T Active DE602007005820D1 (de) 2006-09-04 2007-08-30 Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitoren

Country Status (6)

Country Link
US (1) US8183006B2 (de)
EP (1) EP2064338B1 (de)
AT (1) ATE463582T1 (de)
DE (1) DE602007005820D1 (de)
ES (1) ES2344028T3 (de)
WO (1) WO2008028862A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102348807B (zh) * 2009-01-12 2015-04-15 苏特罗生物制药公司 利用体外蛋白合成体系将非天然氨基酸引入蛋白的单装载体系
GB201115793D0 (en) * 2011-09-13 2011-10-26 Univ Warwick Screening method
KR101711584B1 (ko) * 2012-12-18 2017-03-02 재단법인 의약바이오컨버젼스연구단 변형된 eprs 단백질의 결정 구조 및 이의 결정화 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798240A (en) * 1994-09-13 1998-08-25 Cubist Pharmaceuticals, Inc. Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of use therefore
EP1251175B1 (de) * 2001-04-19 2006-11-08 Institut Pasteur Methode für die Erweiterung der chemischen Zusammensetzung von Proteinen produziert in vivo unter Verwendung von mutierten Aminoacyl-tRNA-Synthetasen ohne Korrekturfunktion

Also Published As

Publication number Publication date
EP2064338B1 (de) 2010-04-07
US8183006B2 (en) 2012-05-22
ES2344028T3 (es) 2010-08-16
EP2064338A1 (de) 2009-06-03
WO2008028862A1 (en) 2008-03-13
ATE463582T1 (de) 2010-04-15
US20100055719A1 (en) 2010-03-04

Similar Documents

Publication Publication Date Title
EA201270213A1 (ru) Способ получения полипептида или вируса, представляющих интерес, в непрерывной клеточной культуре
AR110864A2 (es) Procesos para cultivos celulares
MX356756B (es) Células madre pluripotentes en microportadores.
ATE530636T1 (de) Zellkultur
GB2446525A (en) Stem cell culture medium and method
BRPI0922572A2 (pt) método para cultivar células pluripotentes, cultura de células de mamífero pluripotentes, meio de cultura de célula, célula animal pluripotente isolada, e, método para aumentar a pluripotência de uma célula de mamífero.
MX2008011838A (es) Propagacion de celulas primarias.
Jiang et al. Development of novel tools for the in vitro investigation of drug-induced liver injury
MX2007012786A (es) Ensayo para produccion de circovirus porcino.
TW200634161A (en) Use of flow-cytrometric analysis to optimize cell banking strategies for cho cells
ATE549395T1 (de) Medium und kultur von embryonalen stammzellen
ATE375385T1 (de) Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
ATE517176T1 (de) Verfahren zur kultivierung von geschmackszellen aus säugern
WO2010020876A3 (en) Cell culture method to form aggregates
DE602007005820D1 (de) Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitoren
NO20083274L (no) Fremgangsmate for a vurdere levedyktigheten til tinte celler
DK1495112T3 (da) Cellekulturmedium
Chakrabarti et al. Mitochondrial membrane potential-enriched CHO host: A novel and powerful tool for improving biomanufacturing capability
AU2008232699A8 (en) High expression clones of mammalian cells with fluorescent protein A or G
MX2011009023A (es) Metodos para seleccionar celulas eucarioticas que expresan una proteina heterologa.
MX2010005079A (es) Metodos para medir la viabilidad celular sin usar celulas de control.
WO2008058942A3 (en) Method of cell culture and method of treatment comprising a vepo protein variant
Scheitza et al. Variable NAT1 enzyme activity in long-term cultured human HaCaT keratinocytes
GB0503172D0 (en) Detection method
ATE495440T1 (de) Verfahren zum testen von enzymaktivität in einer histologischen probe

Legal Events

Date Code Title Description
8364 No opposition during term of opposition