ATE463582T1 - Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitoren - Google Patents
Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitorenInfo
- Publication number
- ATE463582T1 ATE463582T1 AT07803072T AT07803072T ATE463582T1 AT E463582 T1 ATE463582 T1 AT E463582T1 AT 07803072 T AT07803072 T AT 07803072T AT 07803072 T AT07803072 T AT 07803072T AT E463582 T1 ATE463582 T1 AT E463582T1
- Authority
- AT
- Austria
- Prior art keywords
- resulting
- trna synthetase
- aminoacyl
- substance
- expression
- Prior art date
Links
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 title abstract 6
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 230000010261 cell growth Effects 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 230000032823 cell division Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/9015—Ligases (6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06120049 | 2006-09-04 | ||
| PCT/EP2007/059063 WO2008028862A1 (en) | 2006-09-04 | 2007-08-30 | A screening method for identifying new aminoacyl-trna synthetase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463582T1 true ATE463582T1 (de) | 2010-04-15 |
Family
ID=38606618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07803072T ATE463582T1 (de) | 2006-09-04 | 2007-08-30 | Screening-verfahren zur identifizierung neuer aminoacyl-trna-synthetase-inhibitoren |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8183006B2 (de) |
| EP (1) | EP2064338B1 (de) |
| AT (1) | ATE463582T1 (de) |
| DE (1) | DE602007005820D1 (de) |
| ES (1) | ES2344028T3 (de) |
| WO (1) | WO2008028862A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2376647B1 (de) * | 2009-01-12 | 2014-03-05 | Sutro Biopharma, Inc. | Mono-ladesystem zur selektiven einführung von nichtnativen aminosäuren in proteine anhand eines in-vitro-proteinsynthesesystems |
| GB201115793D0 (en) * | 2011-09-13 | 2011-10-26 | Univ Warwick | Screening method |
| KR101711584B1 (ko) * | 2012-12-18 | 2017-03-02 | 재단법인 의약바이오컨버젼스연구단 | 변형된 eprs 단백질의 결정 구조 및 이의 결정화 방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5798240A (en) | 1994-09-13 | 1998-08-25 | Cubist Pharmaceuticals, Inc. | Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of use therefore |
| EP1251175B1 (de) | 2001-04-19 | 2006-11-08 | Institut Pasteur | Methode für die Erweiterung der chemischen Zusammensetzung von Proteinen produziert in vivo unter Verwendung von mutierten Aminoacyl-tRNA-Synthetasen ohne Korrekturfunktion |
-
2007
- 2007-08-30 ES ES07803072T patent/ES2344028T3/es active Active
- 2007-08-30 EP EP07803072A patent/EP2064338B1/de not_active Not-in-force
- 2007-08-30 AT AT07803072T patent/ATE463582T1/de not_active IP Right Cessation
- 2007-08-30 US US12/439,814 patent/US8183006B2/en not_active Expired - Fee Related
- 2007-08-30 DE DE602007005820T patent/DE602007005820D1/de active Active
- 2007-08-30 WO PCT/EP2007/059063 patent/WO2008028862A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2064338B1 (de) | 2010-04-07 |
| US20100055719A1 (en) | 2010-03-04 |
| ES2344028T3 (es) | 2010-08-16 |
| US8183006B2 (en) | 2012-05-22 |
| WO2008028862A1 (en) | 2008-03-13 |
| DE602007005820D1 (de) | 2010-05-20 |
| EP2064338A1 (de) | 2009-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |