DE602005022707D1 - Verfahren zur herstellung von carvedilol - Google Patents

Verfahren zur herstellung von carvedilol

Info

Publication number
DE602005022707D1
DE602005022707D1 DE602005022707T DE602005022707T DE602005022707D1 DE 602005022707 D1 DE602005022707 D1 DE 602005022707D1 DE 602005022707 T DE602005022707 T DE 602005022707T DE 602005022707 T DE602005022707 T DE 602005022707T DE 602005022707 D1 DE602005022707 D1 DE 602005022707D1
Authority
DE
Germany
Prior art keywords
formula
carvedilol
yield
enantiomeric
benzylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005022707T
Other languages
English (en)
Inventor
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Garden Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cipla Ltd
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of DE602005022707D1 publication Critical patent/DE602005022707D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE602005022707T 2004-05-20 2005-05-19 Verfahren zur herstellung von carvedilol Active DE602005022707D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0411273.6A GB0411273D0 (en) 2004-05-20 2004-05-20 Process and product
PCT/GB2005/001978 WO2005113502A1 (en) 2004-05-20 2005-05-19 Process for the preparation of carvedilol

Publications (1)

Publication Number Publication Date
DE602005022707D1 true DE602005022707D1 (de) 2010-09-16

Family

ID=32607663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005022707T Active DE602005022707D1 (de) 2004-05-20 2005-05-19 Verfahren zur herstellung von carvedilol

Country Status (12)

Country Link
US (1) US7705163B2 (de)
EP (1) EP1756057B1 (de)
JP (1) JP5118963B2 (de)
KR (1) KR101184920B1 (de)
AT (1) ATE476417T1 (de)
AU (1) AU2005245182B2 (de)
CA (1) CA2566197C (de)
DE (1) DE602005022707D1 (de)
GB (1) GB0411273D0 (de)
NZ (1) NZ551119A (de)
WO (1) WO2005113502A1 (de)
ZA (1) ZA200609206B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2413702A1 (en) 2000-06-28 2002-01-03 Teva Pharmaceuticals Industries Ltd. Carvedilol
PL371409A1 (en) 2002-01-15 2005-06-13 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
KR100746455B1 (ko) 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법
WO2008002683A2 (en) 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate
WO2009116069A2 (en) * 2008-02-04 2009-09-24 Ipca Laboratories Limited Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol
CN102190613B (zh) * 2010-03-14 2014-06-25 浙江华海药业股份有限公司 一种卡维地洛的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2928483C2 (de) * 1979-07-14 1980-12-11 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Herstellung von 4-Hydroxy-carbazol
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
HU227441B1 (en) 1997-11-24 2011-06-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing carvedilol, enantiomers and salts thereof
AU6596800A (en) 1999-09-03 2001-04-10 Asahi Kasei Kabushiki Kaisha Processes for the preparation of tricyclic amino alcohol derivatives
CA2413702A1 (en) * 2000-06-28 2002-01-03 Teva Pharmaceuticals Industries Ltd. Carvedilol
KR100559019B1 (ko) * 2001-01-25 2006-03-10 에프. 호프만-라 로슈 아게 헤테로사이클릭 인덴 유사체의 제조 방법
SK285547B6 (sk) * 2002-11-08 2007-03-01 Zentiva, A. S. Spôsob prípravy Carvedilolu
US7482471B2 (en) * 2003-06-20 2009-01-27 Sun Pharmaceutical Industries Limited Process for preparation of 1-[9H-carbazol-4-yloxy]-3-[{2-(2-(-methoxy)phenoxy)-ethyl}-amino]-propan-2-ol

Also Published As

Publication number Publication date
KR20070026607A (ko) 2007-03-08
AU2005245182A1 (en) 2005-12-01
EP1756057A1 (de) 2007-02-28
JP5118963B2 (ja) 2013-01-16
US7705163B2 (en) 2010-04-27
GB0411273D0 (en) 2004-06-23
NZ551119A (en) 2010-04-30
ZA200609206B (en) 2008-05-28
CA2566197A1 (en) 2005-12-01
CA2566197C (en) 2013-01-22
EP1756057B1 (de) 2010-08-04
US20080234492A1 (en) 2008-09-25
ATE476417T1 (de) 2010-08-15
AU2005245182B2 (en) 2011-08-04
WO2005113502A1 (en) 2005-12-01
KR101184920B1 (ko) 2012-09-28
JP2007538061A (ja) 2007-12-27

Similar Documents

Publication Publication Date Title
JP5184354B2 (ja) 新規１−アリール−３−アザビシクロ［３．１．０］ヘキサン：調製および神経精神障害の処理への使用
CN1671695A (zh) 用作pde4抑制剂的吡咯烷二酮取代的哌啶－2,3－二氮杂萘酮化合物
DE602005022707D1 (de) Verfahren zur herstellung von carvedilol
US10308604B2 (en) Method for producing pyrrole derivative, and intermediate thereof
JP2007500168A5 (de)
WO1998031669A1 (fr) Nouvelles arylpiperazines derivees de piperidine comme medicaments antidepresseurs
WO2006058993A1 (fr) Derives d’arylpiperazine et leur utilisation comme ligands selectifs du recepteur d3 de la dopamine
KR19980701432A (ko) 레보부피바카인 및 관련된 피페리딘카르복스아닐리드 마취제 제조시 사용하기 위한 라세미화 방법(racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents)
CA2297279C (fr) Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO1995001334A1 (fr) Composes indoliques derives d'arylamines comme ligands selectifs des recepteurs 5ht1d et 5ht¿1b?
EP1873140B1 (de) Neue Naphtalinderivate, ihr Herstellungsverfahren und die pharmazeutischen Zusammensetzungen, die sie enthalten
US8299113B2 (en) Bicyclic tetrahydropyrrole compounds
CA2378628C (fr) Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2796641A1 (fr) Nouveau procede de preparation de composes benzoperhydroisoindole
CA2376876C (fr) Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2004518747A (ja) ドーパミンｄ２受容体及びセロトニン再取り込み部位に対する高い親和性を有する８−｛４−［３−（５−フルオロー１ｈ−インドール−３−イル）−プロピル］−ピペラジン−１−イル｝−２−メチル−４ｈ−ベンゾ［１，４］オキサジン−３−オンメシラート
CN1100094A (zh) 用于制备毒扁豆碱的中间体的对映选择性合成方法
RU2006105711A (ru) Производные 2, 4-(гидроксиметилфениламино)пиперидин-1-ил-n-(9h-карбазол-3-ил) ацетамина и родственные им соединения в качестве лигандов нейропептида y 5 (npy5), предназначенные для лечения ожирения
EP1119564B1 (de) Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten
EP1873139A1 (de) Neue Naphtalinderivate, ihr Herstellungsverfahren und die pharmazeutischen Zusammensetzungen, die sie enthalten
FR2918369A1 (fr) Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JPWO2004065368A1 (ja) トランドラプリル合成中間体の製造方法
FR2749846A1 (fr) Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
FR2754261A1 (fr) Derives de quinuclidine, leur preparation et leur application en therapeutique
EP0514267A1 (de) Amidderivate von 1-Amino-Octahydropyrido[2,1-c][1,4]oxazin, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen