DE602005020761D1 - R rna in einem zellfreien system sowie identifizierung von inhibitoren der rna-synthese - Google Patents
R rna in einem zellfreien system sowie identifizierung von inhibitoren der rna-syntheseInfo
- Publication number
- DE602005020761D1 DE602005020761D1 DE602005020761T DE602005020761T DE602005020761D1 DE 602005020761 D1 DE602005020761 D1 DE 602005020761D1 DE 602005020761 T DE602005020761 T DE 602005020761T DE 602005020761 T DE602005020761 T DE 602005020761T DE 602005020761 D1 DE602005020761 D1 DE 602005020761D1
- Authority
- DE
- Germany
- Prior art keywords
- rna
- rnas
- newly
- cell
- free system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000006819 RNA synthesis Effects 0.000 title abstract 2
- 210000004671 cell-free system Anatomy 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 5
- 230000003612 virological effect Effects 0.000 abstract 2
- 241000711549 Hepacivirus C Species 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 241001493065 dsRNA viruses Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55576504P | 2004-03-24 | 2004-03-24 | |
| PCT/US2005/009959 WO2005095655A1 (en) | 2004-03-24 | 2005-03-23 | Quantitative assay for detection of newly synthesized rna in a cell-free system and identification of rna synthesis inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005020761D1 true DE602005020761D1 (de) | 2010-06-02 |
Family
ID=34963570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005020761T Expired - Lifetime DE602005020761D1 (de) | 2004-03-24 | 2005-03-23 | R rna in einem zellfreien system sowie identifizierung von inhibitoren der rna-synthese |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7985541B2 (https=) |
| EP (1) | EP1735470B1 (https=) |
| JP (1) | JP2007530049A (https=) |
| AT (1) | ATE465276T1 (https=) |
| CA (1) | CA2560699A1 (https=) |
| DE (1) | DE602005020761D1 (https=) |
| ES (1) | ES2345053T3 (https=) |
| WO (1) | WO2005095655A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2901807B1 (fr) * | 2006-05-30 | 2013-08-23 | Univ Victor Segalen Bordeaux 2 | Nouveau traitement d'une infection par le vhc |
| US20100062946A1 (en) * | 2008-09-08 | 2010-03-11 | Lis John T | Genome-wide method for mapping of engaged rna polymerases quantitatively and at high resolution |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT281862B (de) * | 1968-07-11 | 1970-06-10 | Robugen Gmbh | Verfahren zur Herstellung von neuen 2'-Desoxyuridinen |
| US5614403A (en) * | 1994-06-01 | 1997-03-25 | Baylor College Of Medicine | In vitro replication system capable of rescuing cloned and manipulated rotavirus genes |
| JPH08154687A (ja) * | 1994-12-12 | 1996-06-18 | Yamanouchi Pharmaceut Co Ltd | アンチセンスオリゴヌクレオチド及び抗ウイルス剤 |
| IT1278077B1 (it) * | 1995-05-25 | 1997-11-17 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal |
| US5770370A (en) * | 1996-06-14 | 1998-06-23 | David Sarnoff Research Center, Inc. | Nuclease protection assays |
| US20030004122A1 (en) * | 1997-11-05 | 2003-01-02 | Leonid Beigelman | Nucleotide triphosphates and their incorporation into oligonucleotides |
| US6004754A (en) * | 1998-01-21 | 1999-12-21 | Becton Dickinson And Company | DNA sequence, related probes and primers for the detection of Streptococcus agalactiae |
| WO2000033635A2 (en) * | 1998-12-10 | 2000-06-15 | Eli Lilly And Company | Primer-independent rna synthesis catalyzed by hcv polymerase |
| AU2405300A (en) * | 1999-01-05 | 2000-07-24 | Advanced Research And Technology Institute, Inc. | Uses of flavivirus rna-dependent rna polymerases |
| DE19915178A1 (de) * | 1999-04-03 | 2000-10-05 | Univ Mainz Johannes Gutenberg | Hepatitis C Virus Zellkultursystem |
| EP1111040A1 (en) * | 1999-12-10 | 2001-06-27 | Daniel Favre | Infection of eukaryotic cells with viruses in vitro |
| US6447994B1 (en) * | 2000-06-20 | 2002-09-10 | The General Hospital Corporation | Production of replicative hepatitis C virus |
-
2005
- 2005-03-23 EP EP05729155A patent/EP1735470B1/en not_active Expired - Lifetime
- 2005-03-23 US US10/593,683 patent/US7985541B2/en not_active Expired - Fee Related
- 2005-03-23 WO PCT/US2005/009959 patent/WO2005095655A1/en not_active Ceased
- 2005-03-23 CA CA002560699A patent/CA2560699A1/en not_active Abandoned
- 2005-03-23 DE DE602005020761T patent/DE602005020761D1/de not_active Expired - Lifetime
- 2005-03-23 ES ES05729155T patent/ES2345053T3/es not_active Expired - Lifetime
- 2005-03-23 AT AT05729155T patent/ATE465276T1/de not_active IP Right Cessation
- 2005-03-23 JP JP2007505210A patent/JP2007530049A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1735470B1 (en) | 2010-04-21 |
| US20070141558A1 (en) | 2007-06-21 |
| ES2345053T3 (es) | 2010-09-14 |
| ATE465276T1 (de) | 2010-05-15 |
| CA2560699A1 (en) | 2005-10-13 |
| JP2007530049A (ja) | 2007-11-01 |
| US7985541B2 (en) | 2011-07-26 |
| EP1735470A1 (en) | 2006-12-27 |
| WO2005095655A1 (en) | 2005-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |